UGM: a more stable procedure for large-scale multiple testing problems, new solutions to identify oncogene

Table 2 Constitution of the gene expression profiles

Gene category	Gene number	Samples S1	Samples S2
Gene category	Gene number	1 to 40	1 to 40
Non differentially expressed genes	Gene 1	X₁₁~N(μ, 1)	X₁₂~N(μ, 1)
	Gene 2
	Gene m₀
Differentially expressed genes	Gene m₀ + 1	X₂₁~N(μ₁, 1)	X₂₂~N(μ₂, 1)
	Gene m₀ + 2
	Gene m

μ~N(0, 2), μ₁~N(0, 1), μ₂~N(2, 1). Non-differentially expressed genes’ number is from 1 to m0, which samples S1 and S2 come from a same population, i.e., μ_1i = μ_2i = μμ_1i = μ_2i = μ. μ₁ = μ₂ = μ~N(0, 2); Differentially expressed genes’ number is from m₀ + 1 to m, i.e., μ₁ ≠ μ₂, μ₁~N(0, 1), μ₂~N(0, 2)μ_1i ≠ μ_2i

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