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Fig. 3 | Theoretical Biology and Medical Modelling

Fig. 3

From: Computational modeling of the effects of autophagy on amyloid-β peptide levels

Fig. 3

Intracellular Aβ concentrations under normal and pathological conditions. The intracellular Aβ concentration CS3 displays oscillatory behaviors depending on the parameters. The basal value of Aβ generation rate constant (i.e., β = β(0)) has been used for the normal condition while β = 100 × β(0) has been used for the early stage AD. For the late stage AD, the specific rate constants of autolysosome formation and intralysosomal hydrolysis have been set equal to rl3 = 0.1 × rl3(0) and rh3 = 0.1 × rh3(0), retaining the high Aβ generation rate as the early state AD. The results in the second column were obtained under 20-fold increase in the autophagosome formation rate constant (rg3 = 20 × rg3(0)) with others the same as those in the first column

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