Fig. 6
From: Computational modeling of the effects of autophagy on amyloid-β peptide levels
Dynamics of autophagy. Fseq, Fmat, and Fhyd denote fluxes of protein sequestration (i.e., autophagosome formation), autophagosome maturation (i.e., autolysosome formation), and intralysosomal hydrolysis steps, respectively. Cg3 and Cl3 are the autophasosome and autolysosome concentrations in Aβ, respectively. Yellow, cyan, and purple lines plot results of autophagy induction (i.e., rg3 = 20 × rg3(0)) in the cases of the basal condition, early stage AD, and late stage AD, respectively. Green, blue, and red lines plot results from simulations with rg3(0) in the same three cases (basal, early stage AD, and late stage AD), respectively