Table 1 Parameters in computer simulations

\( {r}_{gi}^{(0)} \)

1.12 × 10⁻⁵

s⁻¹

Rate constant for autophagosome formation of Si (i = 1, 2, 3) (normal value)

α

1.00 × 10⁻²

(unitless)

Fraction of S2 in protein synthesis rate R_S

β⁽⁰⁾

5.56 × 10⁻¹⁰

s⁻¹

Rate constant for Aβ generation (normal value)

σ

4.00 × 10⁻⁷

s⁻¹

Rate constant for deterioration of S1

ω_g

−9.43 × 10⁻¹

mM^−0.1

Constant for autophagosome formation

(Aβ dependency)

ζ_g

1.00 × 10⁻¹

(unitless)

Constant for autophagosome formation

(Aβ dependency)

ψ_g

1.01 × 10²

mM⁻¹

Constant for autophagosome formation

(Aβ dependency)

k_g

2.83

mM

Constant for autophagosome formation

(ATP dependency)

p_g

3.00

mM

Constant for autophagosome formation

(ATP dependency)

a_g

4.50

mM

Constant for autophagosome formation

(amino acids dependency)

γ_g

1.22

(unitless)

Constant for autophagosome formation

(amino acids dependency)

ξ_g

7.49 × 10⁻²

mM⁻¹

Constant for autophagosome formation

(amino acids dependency)

\( {r}_{li}^{(0)} \)

2.47 × 10⁻⁵

s⁻¹

Rate constant for autolysosome formation of Si (i = 1, 2, 3) (normal value)

k_l

2.83

mM

Constant for autolysosome formation

(ATP dependency)

p_l

3.00

mM

Constant for autolysosome formation

(ATP dependency)

\( {r}_{hi}^{(0)} \)

1.39 × 10⁻⁵

s⁻¹

Rate constant for intralysosomal hydrolysis of Si (i = 1, 2, 3) (normal value)

δ_h

7.24 × 10⁻¹

(unitless)

Exponent for intralysosomal hydrolysis

(ATP dependency)

k_h

2.99

mM

Constant for intralysosomal hydrolysis

(ATP dependency)

r_s

1.48 × 10⁻⁵

mM ⋅ s⁻¹

Rate constant for protein/organelle synthesis

k_s

1.77 × 10¹

mM

Constant for protein/organelle synthesis

(amino acids dependency)

\( {C}_{\mathrm{A}}^{(m)} \)

3.00

mM

ATP concentration corresponding to maximal protein/organelle synthesis rate

r_sec

4.67 × 10⁻⁹

s⁻¹

Rate constant for Aβ secretion

r_clr

2.23 × 10⁻¹

mM⁻¹ ⋅ s⁻¹

Rate constant for Aβ clearance

ω_ext

6.34 × 10⁻⁵

mM

Rate constant for Aβ clearance