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Table 1 Parameters in computer simulations

From: Computational modeling of the effects of autophagy on amyloid-β peptide levels

ParameterValueUnitDescription
\( {r}_{gi}^{(0)} \)1.12 × 10−5s−1Rate constant for autophagosome formation of Si (i = 1, 2, 3) (normal value)
α1.00 × 10−2(unitless)Fraction of S2 in protein synthesis rate RS
β(0)5.56 × 10−10s−1Rate constant for Aβ generation (normal value)
σ4.00 × 10−7s−1Rate constant for deterioration of S1
ωg−9.43 × 10−1mM−0.1Constant for autophagosome formation
(Aβ dependency)
ζg1.00 × 10−1(unitless)Constant for autophagosome formation
(Aβ dependency)
ψg1.01 × 102mM−1Constant for autophagosome formation
(Aβ dependency)
kg2.83mMConstant for autophagosome formation
(ATP dependency)
pg3.00mMConstant for autophagosome formation
(ATP dependency)
ag4.50mMConstant for autophagosome formation
(amino acids dependency)
γg1.22(unitless)Constant for autophagosome formation
(amino acids dependency)
ξg7.49 × 10−2mM−1Constant for autophagosome formation
(amino acids dependency)
\( {r}_{li}^{(0)} \)2.47 × 10−5s−1Rate constant for autolysosome formation of Si (i = 1, 2, 3) (normal value)
kl2.83mMConstant for autolysosome formation
(ATP dependency)
pl3.00mMConstant for autolysosome formation
(ATP dependency)
\( {r}_{hi}^{(0)} \)1.39 × 10−5s−1Rate constant for intralysosomal hydrolysis of Si (i = 1, 2, 3) (normal value)
δh7.24 × 10−1(unitless)Exponent for intralysosomal hydrolysis
(ATP dependency)
kh2.99mMConstant for intralysosomal hydrolysis
(ATP dependency)
rs1.48 × 10−5mM  s−1Rate constant for protein/organelle synthesis
ks1.77 × 101mMConstant for protein/organelle synthesis
(amino acids dependency)
\( {C}_{\mathrm{A}}^{(m)} \)3.00mMATP concentration corresponding to maximal protein/organelle synthesis rate
rsec4.67 × 10−9s−1Rate constant for Aβ secretion
rclr2.23 × 10−1mM−1 s−1Rate constant for Aβ clearance
ωext6.34 × 10−5mMRate constant for Aβ clearance