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Table 1 Parameters in computer simulations

From: Computational modeling of the effects of autophagy on amyloid-β peptide levels

Parameter Value Unit Description
\( {r}_{gi}^{(0)} \) 1.12 × 10−5 s−1 Rate constant for autophagosome formation of Si (i = 1, 2, 3) (normal value)
α 1.00 × 10−2 (unitless) Fraction of S2 in protein synthesis rate RS
β(0) 5.56 × 10−10 s−1 Rate constant for Aβ generation (normal value)
σ 4.00 × 10−7 s−1 Rate constant for deterioration of S1
ωg −9.43 × 10−1 mM−0.1 Constant for autophagosome formation
(Aβ dependency)
ζg 1.00 × 10−1 (unitless) Constant for autophagosome formation
(Aβ dependency)
ψg 1.01 × 102 mM−1 Constant for autophagosome formation
(Aβ dependency)
kg 2.83 mM Constant for autophagosome formation
(ATP dependency)
pg 3.00 mM Constant for autophagosome formation
(ATP dependency)
ag 4.50 mM Constant for autophagosome formation
(amino acids dependency)
γg 1.22 (unitless) Constant for autophagosome formation
(amino acids dependency)
ξg 7.49 × 10−2 mM−1 Constant for autophagosome formation
(amino acids dependency)
\( {r}_{li}^{(0)} \) 2.47 × 10−5 s−1 Rate constant for autolysosome formation of Si (i = 1, 2, 3) (normal value)
kl 2.83 mM Constant for autolysosome formation
(ATP dependency)
pl 3.00 mM Constant for autolysosome formation
(ATP dependency)
\( {r}_{hi}^{(0)} \) 1.39 × 10−5 s−1 Rate constant for intralysosomal hydrolysis of Si (i = 1, 2, 3) (normal value)
δh 7.24 × 10−1 (unitless) Exponent for intralysosomal hydrolysis
(ATP dependency)
kh 2.99 mM Constant for intralysosomal hydrolysis
(ATP dependency)
rs 1.48 × 10−5 mM  s−1 Rate constant for protein/organelle synthesis
ks 1.77 × 101 mM Constant for protein/organelle synthesis
(amino acids dependency)
\( {C}_{\mathrm{A}}^{(m)} \) 3.00 mM ATP concentration corresponding to maximal protein/organelle synthesis rate
rsec 4.67 × 10−9 s−1 Rate constant for Aβ secretion
rclr 2.23 × 10−1 mM−1 s−1 Rate constant for Aβ clearance
ωext 6.34 × 10−5 mM Rate constant for Aβ clearance