Table 2 Estimated characteristic parameters of the antiviral drug combinations
Drug | \( {IC}_{50}^{\mathrm{com}} \) | mcom | RCI95 | |||
|---|---|---|---|---|---|---|
genotype 1b | genotype 2a | genotype 1b | genotype 2a | genotype 1b | genotype 2a | |
ASV&CsA | 0.80 | – | 2.25 | – | 2.95 | – |
ASV&DAS | 0.61 | 0.28 | 1.48 | 1.94 | 4.50 | 1.30 |
ASV&DCV | 0.59 | 0.27 | 1.41 | 1.97 | 4.79 | 1.22 |
ASV&IFNα | 0.53 | – | 1.84 | – | 2.63 | – |
ASV&LDV | 0.65 | 0.47 | 1.43 | 2.30 | 5.14 | 1.63 |
ASV&SCY | 0.88 | – | 1.97 | – | 3.91 | – |
ASV&SOF | 0.54 | 0.24 | 1.47 | 1.75 | 4.01 | 1.29 |
ASV&VX | 0.77 | – | 1.78 | – | 4.04 | – |
DAS&CsA | 0.60 | – | 2.23 | – | 2.23 | – |
DAS&DCV | 0.47 | 0.78 | 1.75 | 2.80 | 2.52 | 2.24 |
DAS&IFNα | 0.40 | – | 1.84 | – | 1.96 | – |
DAS&LDV | 0.54 | 0.86 | 1.72 | 3.41 | 3.00 | 2.05 |
DAS&SCY | 0.57 | – | 1.64 | – | 3.43 | – |
DCV&CsA | 0.50 | – | 2.02 | – | 2.14 | – |
DCV&IFNα | 0.40 | – | 1.79 | – | 2.08 | – |
DCV&SCY | 0.53 | – | 1.75 | – | 2.86 | – |
IFNα&CsA | 0.67 | – | 2.67 | – | 2.02 | – |
IFNα&SCY | 0.59 | – | 2.14 | – | 2.33 | – |
LDV&CsA | 0.43 | – | 1.99 | – | 1.88 | – |
LDV&IFNα | 0.38 | – | 1.82 | – | 1.93 | – |
LDV&SCY | 0.52 | – | 1.79 | – | 2.69 | – |
SMV&CsA | 0.23 | – | 1.20 | – | 2.70 | – |
SMV&DAS | 0.18 | – | 1.31 | – | 1.70 | – |
SMV&DCV | 0.20 | – | 1.26 | – | 2.08 | – |
SMV&IFNα | 0.17 | – | 1.34 | – | 1.56 | – |
SMV&LDV | 0.14 | – | 1.14 | – | 1.92 | – |
SMV&SCY | 0.19 | – | 1.14 | – | 2.50 | – |
SMV&SOF | 0.20 | – | 1.38 | – | 1.71 | – |
SMV&VX | 0.24 | – | 1.45 | – | 1.82 | – |
SOF&CsA | 0.55 | – | 2.18 | – | 2.12 | – |
SOF&DAS | 0.34 | 0.62 | 1.53 | 2.25 | 2.36 | 2.28 |
SOF&DCV | 0.47 | 0.27 | 1.64 | 2.14 | 2.86 | 1.05 |
SOF&IFNα | 0.37 | – | 1.77 | – | 1.94 | – |
SOF&LDV | 0.42 | 0.52 | 1.52 | 2.43 | 2.89 | 1.76 |
SOF&SCY | 0.50 | – | 1.80 | – | 2.56 | – |
SOF&VX | 0.47 | – | 1.57 | – | 3.09 | – |
TPV&IFNα | 0.46 | – | 2.14 | – | 1.81 | – |
TPV&SOF | 0.64 | – | 2.37 | – | 2.23 | – |
VX&CsA | 0.77 | – | 2.71 | – | 2.27 | – |
VX&DCV | 0.47 | – | 1.61 | – | 2.91 | – |
VX&IFNα | 0.47 | – | 1.83 | – | 2.35 | – |
VX&LDV | 0.59 | – | 1.63 | – | 3.58 | – |
VX&SCY | 0.76 | – | 2.05 | – | 3.20 | – |