Table 1 Model variables
From: A mathematical model of circadian rhythms and dopamine
Variable | Description |
|---|---|
BC | BMAL1-CLOCK; protein dimer that drives the transcription of |
| Â | core clock genes |
Pi | PERIOD protein (PER) with i phosphorylations in the cytosol |
C | CRYPTOCHROME protein (CRY) in the cytosol |
PC | PER-CRY protein dimer in the cytosol |
PCN | nuclear PER-CRY protein dimer; inhibits BMAL1-CLOCK |
PN | nuclear PER |
CN | nuclear CRY; inhibits transcription driven by BMAL1-CLOCK |
ROR | retinoic acid receptor-related orphan receptor (ROR) |
REV | orphan nuclear receptor REV-ERB |
S | Bmal1; circadian clock gene |
TH | Tyrosine hydroxylase (TH); rate-limiting enzyme in dopamine |
| Â | synthesis |
MAO | Monoamine oxidase (MAO); catalyzes dopamine degradation |
DRD3 | Dopamine receptor D3 (DRD3) |