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Table 2 Patient-specific clinical parameters

From: How mathematical modeling could contribute to the quantification of metastatic tumor burden under therapy: insights in immunotherapeutic treatment of non-small cell lung cancer

Patient KE-01 KE-02 KE-03
Sex F M M
Histology Adenosquamous Carcinoma Adenocarcinoma Adenocarcinoma
Molecular Pathology EGFR-, PD-L1 5, CK7+, TTF1+, EGFR-, ALK-, KRAS-, BRAF-, EGFR-, ALK-, KRAS-,
  p63+, Chromogr-, Syn- PD-L1 50, Ros1- BRAF- PD-L1 5
TNM Classification cT4 cN2 cM1b cT1b pN3 M1a cT4 cN3 cM0
ECOG-PS 1 0 0
Size of PT at primary diagnosis [ml] 240.74 14.27 71.75
  1. The three patients with NSCLC examined in this study were routinely treated with a prior Cisplatin/Pemetrexed Chemotherapy and/or 1L/2L immunotherapy (Pembrolizumab or Nivolumab), see “Results” section 4 for further details. The molecular pathology features diverse histological testing of tumor markers as follows: EGFR: Epidermal Growth Factor Receptor, PD-L1: Programmed Death Ligand 1, CK7: Cytokeratin 7, TTF1: Thyroid Transcription Factor 1, p63: Tumor Protein 63, Chromogr: Chromogranin A, Syn: Synaptophysin, ALK: EML4-ALK fusion protein, KRAS: Kirsten Rat Sarcoma, BRAF: rapid accelerated fibrosarcoma (B-Type), Ros1: rather often translocated in sarcoma. The sign “+” or “-” indicates a positive respective negative test result for those gene translocations and upregulations. The connection of mentioned markers to the diagnosis of tumor histology is explained in the first section