Patient | KE-01 | KE-02 | KE-03 | ||
---|---|---|---|---|---|
Parameter | Explanation | Origin | |||
K | Environmental carrying capacity [cells] | 1012 | 1012 | 1012 | fixed, [26] |
a | Growth rate [1/day] | 7.284·10−3 | 6.877·10−3 | 6.984·10−3 | fitted |
(1.041·10−3) | (3.734·10−3) | (0.611·10−3) | |||
m | Colonization coefficient [1/cell 1/day] | 1.635·10−7 | 1.984·10−7 | 2.738·10−7 | fitted |
(0.157·10−7) | (3.816·10−7) | (0.490·10−7) | |||
α | Fractal dimension of tumor cells able to metastasize [-] | 2/3 | 2/3 | 2/3 | fixed, [55] |
Chemotherapeutic drug in use | CisPT/Pemet. (1L) | - | CisPT/Pemet. (1L) | Data | |
μ0 | Initial chemotherapy efficiency [-] | 0.237 (1.000) | - | 0.081 (0.917) | fitted |
μ∗ | Refractory effect under chemotherapy application [-] | 0.132 (1.000) | - | 0.132 (1.321) | fitted |
Immunotherapeutic drug in use | Pembr. (2L) | Nivol. (1L) | Pembr. (2L) | Data | |
χ | Immunotherapeutic effect under application [1/day] | 0.067 (0.096) | 0.499 (0.078) | 0.088 (0.011) | fitted |
\(c_{i}^{50}\) | Drug concentration of immunotherapeutic drug | 1.012·1016 | 1.010·1016 | 1.009·1016 | fitted |
for half-maximal response [molecules per volume] | (0.142·1016) | (0.089·1016) | (0.020·1016) | ||
\(c_{i}^{st}\) | Drug concentration of immunotherapeutic drug | 1.41·1018 | 2.77·1018 | 1.41·1018 | estimated, |
in serum steady state [molecules per volume] | cf. Eq. (10) | ||||
T | Age of primary tumor at diagnosis [d] | 407.1 | 272.2 | 336.5 | estimated, |
cf. Eq. (3) | |||||
TVDT | Tumor volume doubling time at diagnosis [d] | 91.6 | 25.9 | 43.7 | estimated, |
cf. Eq. (4) |