On the relationship between inhibition and receptor occupancy by nondepolarizing neuromuscular blocking drugs

Table 1 Setting of parameters for numerical simulation in base case

Symbol	Meaning	Value
[ R]_total	Concentration of AChRs in the synaptic cleft	7.75×10⁻⁵M [15]
[ A]_init	Initial concentration of ACh immediately after the stimulus	7.75×10⁻⁶M [15]
k_decay	Rate constant of the decay of the concentration of free ACh	1.2×10⁴s⁻¹ [15]
k_dissA1	Dissociation rate constant for ACh with site1 of AChR	1.8×10⁴s⁻¹ [13, 14]
k_dissA2	Dissociation rate constant for ACh with site2 of AChR	1.8×10⁴s⁻¹ [13, 14]
k_assocA1	Association rate constant for ACh with site1 of AChR ^∗	1.1×10⁸M⁻¹.s⁻¹ [13, 14]
k_assocA2	Association rate constant for ACh with site2 of AChR ^∗	1.1×10⁸M⁻¹s⁻¹ [13, 14]
k_dissD1	Dissociation rate constant for NDNB with site1 of AChR ^∗	10s⁻¹ [4, 5]
k_dissD2	Dissociation rate constant for NDNB with site2 of AChR ^∗	10s⁻¹ [4, 5]
k_assocD1	Association rate constant for NDNB with site1 of AChR ^∗	1.0×10⁸M⁻¹s⁻¹ [4, 5]
k_assocD2	Association rate constant for NDNB with site2 of AChR ^∗	1.0×10⁸M⁻¹s⁻¹ [4, 5]
k_close	Rate constant of channel closing of AChR	1.2×10³s⁻¹ [14]
k_open	Rate constant of channel opening of AChR	5.0×10⁴s⁻¹ [14]

∗ These dissociation and association rate constants are varied in numerical analysis

ISSN: 1742-4682