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Table 1 Setting of parameters for numerical simulation in base case

From: On the relationship between inhibition and receptor occupancy by nondepolarizing neuromuscular blocking drugs

Symbol Meaning Value
[ R]total Concentration of AChRs in the synaptic cleft 7.75×10−5M [15]
[ A]init Initial concentration of ACh immediately after the stimulus 7.75×10−6M [15]
kdecay Rate constant of the decay of the concentration of free ACh 1.2×104s−1 [15]
kdissA1 Dissociation rate constant for ACh with site1 of AChR 1.8×104s−1 [13, 14]
kdissA2 Dissociation rate constant for ACh with site2 of AChR 1.8×104s−1 [13, 14]
kassocA1 Association rate constant for ACh with site1 of AChR 1.1×108M−1.s−1 [13, 14]
kassocA2 Association rate constant for ACh with site2 of AChR 1.1×108M−1s−1 [13, 14]
kdissD1 Dissociation rate constant for NDNB with site1 of AChR 10s−1 [4, 5]
kdissD2 Dissociation rate constant for NDNB with site2 of AChR 10s−1 [4, 5]
kassocD1 Association rate constant for NDNB with site1 of AChR 1.0×108M−1s−1 [4, 5]
kassocD2 Association rate constant for NDNB with site2 of AChR 1.0×108M−1s−1 [4, 5]
kclose Rate constant of channel closing of AChR 1.2×103s−1 [14]
kopen Rate constant of channel opening of AChR 5.0×104s−1 [14]
  1. These dissociation and association rate constants are varied in numerical analysis