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  1. Content type: Review

    The public benefit of test-and-treat has induced a need to justify goodness for the public, and mathematical modeling studies have played a key role in designing and evaluating the test-and-treat strategy for ...

    Authors: Kyeongah Nah, Hiroshi Nishiura, Naho Tsuchiya, Xiaodan Sun, Yusuke Asai and Akifumi Imamura

    Citation: Theoretical Biology and Medical Modelling 2017 14:16

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  2. Content type: Research

    A large epidemic of cholera, caused by Vibrio cholerae, serotype Ogawa, has been ongoing in Yemen, 2017. To improve the situation awareness, the present study aimed to forecast the cholera epidemic, explicitly ad...

    Authors: Hiroshi Nishiura, Shinya Tsuzuki, Baoyin Yuan, Takayuki Yamaguchi and Yusuke Asai

    Citation: Theoretical Biology and Medical Modelling 2017 14:14

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  3. Content type: Research

    Herpes Simplex Virus Type 2 (HSV-2) is one of the most common sexually transmitted diseases. Although there is still no licensed vaccine for HSV-2, a theoretical investigation of the potential effects of a vac...

    Authors: Jinliang Wang, Xiaoqing Yu, Heidi L. Tessmer, Toshikazu Kuniya and Ryosuke Omori

    Citation: Theoretical Biology and Medical Modelling 2017 14:13

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  4. Content type: Research

    With up to 240 million people chronically infected with hepatitis B worldwide, including an estimated 2 million in the United States, widespread screening is needed to link the infected to care and decrease th...

    Authors: Martin A. Sehr, Kartik D. Joshi, John M. Fontanesi, Robert J. Wong, Robert R. Bitmead and Robert G. Gish

    Citation: Theoretical Biology and Medical Modelling 2017 14:11

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  5. Content type: Research

    The host range of human immunodeficiency virus (HIV) is quite narrow. Therefore, analyzing HIV-1 pathogenesis in vivo has been limited owing to lack of appropriate animal model systems. To overcome this, chime...

    Authors: Shoya Iwanami, Yusuke Kakizoe, Satoru Morita, Tomoyuki Miura, Shinji Nakaoka and Shingo Iwami

    Citation: Theoretical Biology and Medical Modelling 2017 14:9

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  6. Content type: Research

    When administering vancomycin hydrochloride (VCM), the initial dose is adjusted to ensure that the steady-state trough value (Css-trough) remains within the effective concentration range. However, the Css-trou...

    Authors: Yasuyuki Kourogi, Kenji Ogata, Norito Takamura, Jin Tokunaga, Nao Setoguchi, Mitsuhiro Kai, Emi Tanaka and Susumu Chiyotanda

    Citation: Theoretical Biology and Medical Modelling 2017 14:8

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  7. Content type: Research

    Arteriovenous fistula (AVF) maturation failure remains a major cause of morbidity and mortality in hemodialysis patients. The two major etiologies of AVF maturation failure are early neointimal hyperplasia dev...

    Authors: Daniel Pike, Yan-Ting Shiu, Maheshika Somarathna, Lingling Guo, Tatyana Isayeva, John Totenhagen and Timmy Lee

    Citation: Theoretical Biology and Medical Modelling 2017 14:5

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    The Correction to this article has been published in Theoretical Biology and Medical Modelling 2019 16:8

  8. Content type: Research

    The transmission dynamics of Tuberculosis (TB) involve complex epidemiological and socio-economical interactions between individuals living in highly distinct regional conditions. The level of exogenous reinfe...

    Authors: Victor Moreno, Baltazar Espinoza, Kamal Barley, Marlio Paredes, Derdei Bichara, Anuj Mubayi and Carlos Castillo-Chavez

    Citation: Theoretical Biology and Medical Modelling 2017 14:3

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  9. Content type: Research

    Urine production in the kidney is generally thought to be an energy-intensive process requiring large amounts of metabolic activity to power active transport mechanisms. This study uses a thermodynamic analysi...

    Authors: Robert H. Louw, David M. Rubin, David Glasser, Robyn F. R. Letts and Diane Hildebrandt

    Citation: Theoretical Biology and Medical Modelling 2017 14:2

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  10. Content type: Research

    The progression of Human Immunodeficiency Virus (HIV) within host includes typical stages and the Antiretroviral Therapy (ART) is shown to be effective in slowing down this progression. There are great challen...

    Authors: Yanni Xiao, Xiaodan Sun, Sanyi Tang, Yicang Zhou, Zhihang Peng, Jianhong Wu and Ning Wang

    Citation: Theoretical Biology and Medical Modelling 2017 14:1

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  11. Content type: Research

    Florida State has reported autochthonous transmission of Zika virus since late July 2016. Here we assessed the transmissibility associated with the outbreak and generated a short-term forecast.

    Authors: Linh Dinh, Gerardo Chowell, Kenji Mizumoto and Hiroshi Nishiura

    Citation: Theoretical Biology and Medical Modelling 2016 13:20

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  12. Content type: Research

    Epidemic models are being extensively used to understand the main pathways of spread of infectious diseases, and thus to assess control methods. Schools are well known to represent hot spots for epidemic sprea...

    Authors: Valentina Clamer, Ilaria Dorigatti, Laura Fumanelli, Caterina Rizzo and Andrea Pugliese

    Citation: Theoretical Biology and Medical Modelling 2016 13:19

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  13. Content type: Research

    An artificial neural network approach was chosen to model the outcome of the complex signaling pathways in the gastro-intestinal tract and other peripheral organs that eventually produce the satiety feeling in...

    Authors: Shaji Krishnan, Henk F. J. Hendriks, Merete L. Hartvigsen and Albert A. de Graaf

    Citation: Theoretical Biology and Medical Modelling 2016 13:17

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  14. Content type: Research

    This study is mainly motivated by the need of understanding how the diffusion behavior of a biomolecule (or even of a larger object) is affected by other moving macromolecules, organelles, and so on, inside a ...

    Authors: Matteo Gori, Irene Donato, Elena Floriani, Ilaria Nardecchia and Marco Pettini

    Citation: Theoretical Biology and Medical Modelling 2016 13:13

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  15. Content type: Research

    Dengue is a common mosquito-borne viral disease epidemic especially in tropical and sub-tropical regions where water sanitation is not substantially controlled. However, dengue epidemics sometimes occur in non...

    Authors: Hiroki Masui, Itsuki Kakitani, Shumpei Ujiyama, Kazuyoshi Hashidate, Masataka Shiono and Kazue Kudo

    Citation: Theoretical Biology and Medical Modelling 2016 13:12

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  16. Content type: Research

    One of the major issues in current pharmaceutical development is potential hepatotoxicity and drug-induced liver damage. This is due to the unique metabolic processes performed in the liver to prevent accumula...

    Authors: Vahid Rezania, Dennis Coombe and Jack A. Tuszynski

    Citation: Theoretical Biology and Medical Modelling 2016 13:9

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  17. Content type: Research

    Quantitative evaluation of insulin regulation on plasma glucose and free fatty acid (FFA) in response to external glucose challenge is clinically important to assess the development of insulin resistance (Worl...

    Authors: Yanjun Li, Carson C. Chow, Amber B. Courville, Anne E. Sumner and Vipul Periwal

    Citation: Theoretical Biology and Medical Modelling 2016 13:8

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  18. Content type: Review

    In this review, we report on breast cancer’s molecular features and on how high throughput technologies are helping in understanding the dynamics of tumorigenesis and cancer progression with the aim of develop...

    Authors: Nicolas Carels, Lizânia Borges Spinassé, Tatiana Martins Tilli and Jack Adam Tuszynski

    Citation: Theoretical Biology and Medical Modelling 2016 13:7

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  19. Content type: Research

    Mathematical modeling of biological processes is widely used to enhance quantitative understanding of bio-medical phenomena. This quantitative knowledge can be applied in both clinical and experimental setting...

    Authors: Yoichi Watanabe, Erik L. Dahlman, Kevin Z. Leder and Susanta K. Hui

    Citation: Theoretical Biology and Medical Modelling 2016 13:6

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  20. Content type: Research

    Previously, we applied basic group theory and related concepts to scales of measurement of clinical disease states and clinical findings (including laboratory data). To gain a more concrete comprehension, we h...

    Authors: Jitsuki Sawamura, Shigeru Morishita and Jun Ishigooka

    Citation: Theoretical Biology and Medical Modelling 2016 13:5

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  21. Content type: Software

    Mechanistic explanations of cell-level phenomena typically adopt an observer perspective. Explanations developed from a cell’s perspective may offer new insights. Agent-based models lend themselves to model fr...

    Authors: Ryan C Kennedy, Glen EP Ropella and C Anthony Hunt

    Citation: Theoretical Biology and Medical Modelling 2016 13:4

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  22. Content type: Research

    The critically ill can have persistent dysglycemia during the “subacute” recovery phase of their illness because of altered gene expression; it is also not uncommon for these patients to receive continuous ent...

    Authors: Richard J. Strilka, Mamie C. Stull, Michael S. Clemens, Stewart C. McCaver and Scott B. Armen

    Citation: Theoretical Biology and Medical Modelling 2016 13:3

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  23. Content type: Research

    DNA sequence can be viewed as an unknown language with words as its functional units. Given that most sequence alignment algorithms such as the motif discovery algorithms depend on the quality of background in...

    Authors: Zhi Li, Hongyan Cao, Yuehua Cui and Yanbo Zhang

    Citation: Theoretical Biology and Medical Modelling 2016 13:2

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  24. Content type: Research

    Eelgrass grants important ecological benefits including a nursery for waterfowl and fish species, shoreline stabilization, nutrient recycling and carbon sequestration. Upon the exacerbation of deleterious anth...

    Authors: Héctor Echavarría-Heras, Cecilia Leal-Ramírez, Enrique Villa-Diharce and Nohe R. Cazarez-Castro

    Citation: Theoretical Biology and Medical Modelling 2015 12:30

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  25. Content type: Research

    Cells are open complex thermodynamic systems. They can be also regarded as complex engines that execute a series of chemical reactions. Energy transformations, thermo-electro-chemical processes and transports ...

    Authors: Umberto Lucia

    Citation: Theoretical Biology and Medical Modelling 2015 12:29

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  26. Content type: Research

    The quantification of the spatial order of biological patterns or mosaics provides useful information as many properties are determined by the spatial distribution of their constituent elements. These are usua...

    Authors: Gabriela Contreras-Figueroa, Luis Hernández-Sandoval and José L. Aragón

    Citation: Theoretical Biology and Medical Modelling 2015 12:27

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  27. Content type: Research

    Gonadal sex determination (GSD) in humans is a complex biological process that takes place in early stages of embryonic development when the bipotential gonadal primordium (BGP) differentiates towards testes o...

    Authors: Osiris Ríos, Sara Frias, Alfredo Rodríguez, Susana Kofman, Horacio Merchant, Leda Torres and Luis Mendoza

    Citation: Theoretical Biology and Medical Modelling 2015 12:26

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  28. Content type: Research

    The electrocardiogram (ECG) is a diagnostic tool that records the electrical activity of the heart, and depicts it as a series of graph-like tracings, or waves. Being able to interpret these details allows dia...

    Authors: Abdelghani Ghazdali, Abdelilah Hakim, Amine Laghrib, Nezha Mamouni and Said Raghay

    Citation: Theoretical Biology and Medical Modelling 2015 12:25

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  29. Content type: Research

    Low back pain exerts a tremendous burden on individual patients and society due to its prevalence and ability to cause long-term disability. Contemporary treatment and prevention efforts are stymied by the abs...

    Authors: Chang-Jiang Zheng and James Chen

    Citation: Theoretical Biology and Medical Modelling 2015 12:24

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  30. Content type: Research

    DNA double-strand breaks (DSBs) are highly cytotoxic and mutagenic. MRE11 plays an essential role in repairing DNA by cleaving broken ends through its 3′ to 5′ exonuclease and single-stranded DNA endonuclease act...

    Authors: Imen Rekik, Zayneb Chaabene, C. Douglas Grubb, Noureddine Drira, Foued Cheour and Amine Elleuch

    Citation: Theoretical Biology and Medical Modelling 2015 12:23

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  31. Content type: Research

    Despite the unprecedented and increasing amount of data, relatively little progress has been made in molecular characterization of mechanisms underlying Parkinson’s disease. In the area of Parkinson’s research...

    Authors: Erfan Younesi, Ashutosh Malhotra, Michaela Gündel, Phil Scordis, Alpha Tom Kodamullil, Matt Page, Bernd Müller, Stephan Springstubbe, Ullrich Wüllner, Dieter Scheller and Martin Hofmann-Apitius

    Citation: Theoretical Biology and Medical Modelling 2015 12:20

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  32. Content type: Research Article

    The FA/BRCA pathway repairs DNA interstrand crosslinks. Mutations in this pathway cause Fanconi anemia (FA), a chromosome instability syndrome with bone marrow failure and cancer predisposition. Upon DNA damag...

    Authors: Alfredo Rodríguez, Leda Torres, Ulises Juárez, David Sosa, Eugenio Azpeitia, Benilde García-de Teresa, Edith Cortés, Rocío Ortíz, Ana M. Salazar, Patricia Ostrosky-Wegman, Luis Mendoza and Sara Frías

    Citation: Theoretical Biology and Medical Modelling 2015 12:19

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  33. Content type: Research

    Functional information is normally communicated using specific, context-dependent strings of symbolic characters. This is true within the human realm (texts and computer programs), and also within the biologic...

    Authors: John Sanford, Wesley Brewer, Franzine Smith and John Baumgardner

    Citation: Theoretical Biology and Medical Modelling 2015 12:18

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  34. Content type: Research

    Cachexia affects most patients with incurable cancer. We hypothesize that in metastatic cancer the mass of the tumor as well as its level of anaerobic energy metabolism play a critical role in describing its e...

    Authors: Douglas E. Friesen, Vickie E. Baracos and Jack A. Tuszynski

    Citation: Theoretical Biology and Medical Modelling 2015 12:17

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