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  1. Content type: Commentary

    Nanoscale electrostatic microtubule disassembly forces between positively charged molecules in kinetochores and negative charges on plus ends of microtubules have been implicated in poleward chromosome motions...

    Authors: L John Gagliardi and Daniel H Shain

    Citation: Theoretical Biology and Medical Modelling 2014 11:12

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  2. Content type: Research

    The modelling framework is proposed to study protection properties of antibodies to neutralize the effects of the plant toxin (ricin). The present study extends our previous work by including (i) the model of ...

    Authors: Vladas Skakauskas, Pranas Katauskis, Alex Skvortsov and Peter Gray

    Citation: Theoretical Biology and Medical Modelling 2014 11:11

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  3. Content type: Review

    Since cell membranes are weak sources of electrostatic fields, this ECG interpretation relies on the analogy between cells and electrets. It is here assumed that cell-bound electric fields unite, reach the bod...

    Authors: Sven Kurbel

    Citation: Theoretical Biology and Medical Modelling 2014 11:10

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  4. Content type: Review

    Transmission dynamic models linked to economic analyses often form part of the decision making process when introducing new chlamydia screening interventions. Outputs from these transmission dynamic models can...

    Authors: Bethan Davies, Sarah-Jane Anderson, Katy ME Turner and Helen Ward

    Citation: Theoretical Biology and Medical Modelling 2014 11:8

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  5. Content type: Research

    Alan Turing’s work in Morphogenesis has received wide attention during the past 60 years. The central idea behind his theory is that two chemically interacting diffusible substances are able to generate stable...

    Authors: Tatiana T Marquez-Lago and Pablo Padilla

    Citation: Theoretical Biology and Medical Modelling 2014 11:7

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  6. Content type: Research

    Adverse remodeling of the left ventricle (LV) following myocardial infarction (MI) leads to heart failure. Recent studies have shown that scar anisotropy is a determinant of cardiac function post-MI, however i...

    Authors: Andrew P Voorhees and Hai-Chao Han

    Citation: Theoretical Biology and Medical Modelling 2014 11:6

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  7. Content type: Research

    There has been a variation in published opinions toward the effectiveness of school closure which is implemented reactively when substantial influenza transmissions are seen at schools. Parameterizing an age-s...

    Authors: Hiroshi Nishiura, Keisuke Ejima, Kenji Mizumoto, Shinji Nakaoka, Hisashi Inaba, Seiya Imoto, Rui Yamaguchi and Masaya M Saito

    Citation: Theoretical Biology and Medical Modelling 2014 11:5

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  8. Content type: Research

    Hematopoiesis is a complex process that encompasses both pro-mitotic and anti-mitotic stimuli. Pharmacological agents used in chemotherapy have a prominent anti-mitotic effect. The approach of inhibiting cell ...

    Authors: Christina L Mouser, Eliana S Antoniou, James Tadros and Evros K Vassiliou

    Citation: Theoretical Biology and Medical Modelling 2014 11:4

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  9. Content type: Research

    Determining the pandemic potential of an emerging infectious disease and how it depends on the various epidemic and population aspects is critical for the preparation of an adequate response aimed at its contr...

    Authors: Andrea Apolloni, Chiara Poletto, José J Ramasco, Pablo Jensen and Vittoria Colizza

    Citation: Theoretical Biology and Medical Modelling 2014 11:3

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  10. Content type: Research

    Codon degeneracy and codon usage by organisms is an interesting and challenging problem. Researchers demonstrated the relation between codon usage and various functions or properties of genes and proteins, suc...

    Authors: Mohammad-Hadi Foroughmand-Araabi, Bahram Goliaei, Kasra Alishahi and Mehdi Sadeghi

    Citation: Theoretical Biology and Medical Modelling 2014 11:2

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  11. Content type: Review

    Understanding how developmental systems evolve over time is a key question in stem cell and developmental biology research. However, due to hurdles of existing experimental techniques, our understanding of the...

    Authors: Yaki Setty

    Citation: Theoretical Biology and Medical Modelling 2014 11:1

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  12. Content type: Research

    When anti-tumour therapy is administered to a tumour-host environment, an asymptotic tapering extremity of the tumour cell distribution is noticed. This extremity harbors a small number of residual tumour cell...

    Authors: Suhela Kapoor, VP Subramanyam Rallabandi, Chandrashekhar Sakode, Radhakant Padhi and Prasun K Roy

    Citation: Theoretical Biology and Medical Modelling 2013 10:68

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  13. Content type: Research

    Abdominal aortic aneurysms (AAA) are currently being treated based on the maximum diameter criterion which has often been proven insufficient to determine rupture risk in case of every AAA. We analyzed a rare ...

    Authors: Nikolaos Kontopodis, Eleni Metaxa, Yannis Papaharilaou, Efstratios Georgakarakos, Dimitrios Tsetis and Christos V Ioannou

    Citation: Theoretical Biology and Medical Modelling 2013 10:67

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  14. Content type: Software

    Normal colon crypts consist of stem cells, proliferating cells, and differentiated cells. Abnormal rates of proliferation and differentiation can initiate colon cancer. We have measured the variation in the nu...

    Authors: Rafael Bravo and David E Axelrod

    Citation: Theoretical Biology and Medical Modelling 2013 10:66

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  15. Content type: Research

    The hypothalamic-pituitary-adrenal axis (HPA axis) is a major part of the neuroendocrine system responsible for the regulation of the response to physical or mental stress and for the control of the synthesis ...

    Authors: Clemens A Zarzer, Martin G Puchinger, Gottfried Köhler and Philipp Kügler

    Citation: Theoretical Biology and Medical Modelling 2013 10:65

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  16. Content type: Research

    Classical mechanical dilators for cervical dilation are associated with various complications, such as uterine perforation, cervical laceration, infections and intraperitoneal hemorrhage. A new medical device ...

    Authors: Nenad Filipovic, Dalibor Nikolic, Igor Saveljic, Irena Tanaskovic, Nebojsa Zdravkovic, Aleksandar Zivanovic, Petar Arsenijevic, Branislav Jeremic and Slobodan Arsenijevic

    Citation: Theoretical Biology and Medical Modelling 2013 10:64

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  17. Content type: Research

    N-Acetylserotonin O-methyltransferase (ASMT) is an enzyme which by converting nor-melatonin to melatonin catalyzes the final reaction in melatonin biosynthesis in tryptophan metabolism pathway. High Expression...

    Authors: Syed Sikander Azam and Sumra Wajid Abbasi

    Citation: Theoretical Biology and Medical Modelling 2013 10:63

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  18. Content type: Research

    The criteria for organ sharing has developed a system that prioritizes liver transplantation (LT) for patients with hepatocellular carcinoma (HCC) who have the highest risk of wait-list mortality. In some coun...

    Authors: Eleazar Chaib, Marcos Amaku, Francisco AB Coutinho, Luis F Lopez, Marcelo N Burattini, Luiz AC D’Albuquerque and Eduardo Massad

    Citation: Theoretical Biology and Medical Modelling 2013 10:60

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  19. Content type: Research

    Major depressive disorder (MDD) is a multifactorial disorder known to be influenced by both genetic and environmental factors. MDD presents a heritability of 37%, and a genetic contribution has also been obser...

    Authors: Oscar Andrés Moreno-Ramos, Maria Claudia Lattig and Andrés Fernando González Barrios

    Citation: Theoretical Biology and Medical Modelling 2013 10:59

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  20. Content type: Commentary

    The classification of Acute Coronary Syndrome (ACS), using artificial intelligence (AI), has recently drawn the attention of the medical researchers. Using this approach, patients with myocardial infarction ca...

    Authors: Nader Salari, Shamarina Shohaimi, Farid Najafi, Meenakshii Nallappan and Isthrinayagy Karishnarajah

    Citation: Theoretical Biology and Medical Modelling 2013 10:57

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  21. Content type: Research

    Mitogen-activated protein kinase-activated protein kinase 5 (MK5) is involved in one of the major signaling pathways in cells, the mitogen-activated protein kinase pathway. MK5 was discovered in 1998 by the gr...

    Authors: Inger Lindin, Yimingjiang Wuxiuer, Irina Kufareva, Ruben Abagyan, Ugo Moens, Ingebrigt Sylte and Aina Westrheim Ravna

    Citation: Theoretical Biology and Medical Modelling 2013 10:56

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  22. Content type: Research

    The response to endotoxin (LPS), and subsequent signal transduction lead to the production of cytokines such as tumor necrosis factor-α (TNF-α) by innate immune cells. Cells or organisms pretreated with endoto...

    Authors: Catalin Vasilescu, Mircea Olteanu, Paul Flondor and George A Calin

    Citation: Theoretical Biology and Medical Modelling 2013 10:55

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  23. Content type: Research

    Rate-dependent effects on the C a2+ sub-system in a rat ventricular myocyte are investigated. Here, we employ a deterministic mathematical model describing various C a2+ signalling pathways under voltage clamp (V...

    Authors: Abhilash Krishna, Miguel Valderrábano, Philip T Palade and John W Clark Jr

    Citation: Theoretical Biology and Medical Modelling 2013 10:54

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  24. Content type: Research

    We develop a physiologically-based lattice model for the transport and metabolism of drugs in the functional unit of the liver, called the lobule. In contrast to earlier studies, we have emphasized the dominan...

    Authors: Vahid Rezania, Rebeccah Marsh, Dennis Coombe and Jack Tuszynski

    Citation: Theoretical Biology and Medical Modelling 2013 10:52

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  25. Content type: Research

    We extend a physiologically-based lattice model for the transport and metabolism of drugs in the liver lobule (liver functional unit) to consider structural and spatial variability. We compare predicted drug c...

    Authors: Vahid Rezania, Rebeccah Marsh, Dennis Coombe and Jack Tuszynski

    Citation: Theoretical Biology and Medical Modelling 2013 10:53

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  26. Content type: Research

    The interest in cell membrane has grown drastically for their important role as controllers of biological functions in health and illness. In fact most important physiological processes are intimately related ...

    Authors: Noureddine Alaa and Hamid Lefraich

    Citation: Theoretical Biology and Medical Modelling 2013 10:51

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  27. Content type: Research

    Energy homeostasis ensures the functionality of the entire organism. The human brain as a missing link in the global regulation of the complex whole body energy metabolism is subject to recent investigation. T...

    Authors: Britta Göbel, Kerstin M Oltmanns and Matthias Chung

    Citation: Theoretical Biology and Medical Modelling 2013 10:50

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  28. Content type: Research

    Protein tyrosine phosphatase receptor type Q (PTPRQ) is an unusual PTP that has intrinsic dephosphorylating activity for various phosphatidyl inositides instead of phospho-tyrosine substrates. Although PTPRQ w...

    Authors: Hwangseo Park, Keum Ran Yu, Bonsu Ku, Bo Yeon Kim and Seung Jun Kim

    Citation: Theoretical Biology and Medical Modelling 2013 10:49

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  29. Content type: Research

    Hyperosmotic glucose is injected intravenously when an intravenous glucose tolerance test (IVGTT) is initiated. The extent and time period of plasma volume expansion that occurs in response to the glucose load...

    Authors: Robert G Hahn, Thomas Nyström and Stefan Ljunggren

    Citation: Theoretical Biology and Medical Modelling 2013 10:48

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  30. Content type: Research

    Gliomas are the most common types of brain cancer, well known for their aggressive proliferation and the invasive behavior leading to a high mortality rate. Several mathematical models have been developed for ...

    Authors: Maria Papadogiorgaki, Panagiotis Koliou, Xenofon Kotsiakis and Michalis E Zervakis

    Citation: Theoretical Biology and Medical Modelling 2013 10:47

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  31. Content type: Research

    The most common bariatric surgery, Roux-en-Y gastric bypass, leads to glycemia normalization in most patients long before there is any appreciable weight loss. This effect is too large to be attributed purely ...

    Authors: Roland E Allen, Tyler D Hughes, Jia Lerd Ng, Roberto D Ortiz, Michel Abou Ghantous, Othmane Bouhali, Philippe Froguel and Abdelilah Arredouani

    Citation: Theoretical Biology and Medical Modelling 2013 10:45

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  32. Content type: Research

    The application of highly active antiretroviral therapy (HAART) against HIV can reduce and maintain viral load below detection limit in many patients. Continuous HAART, however, can have severe side effects. I...

    Authors: Leonardo Oña, Roger D Kouyos, Michael Lachmann and Sebastian Bonhoeffer

    Citation: Theoretical Biology and Medical Modelling 2013 10:44

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  33. Content type: Editorial

    Theoretical biology encompasses a broad range of biological disciplines ranging from mathematical biology and biomathematics to philosophy of biology. Adopting a broad definition of "biology", Theoretical Biol...

    Authors: Hiroshi Nishiura, Edward A Rietman and Rongling Wu

    Citation: Theoretical Biology and Medical Modelling 2013 10:43

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  34. Content type: Commentary

    There exists a very large literature suggesting that T cells come in a variety of species and that without the action of Tregs tumors would seldom survive inhibition by T cell effectors. We believe that much o...

    Authors: Richmond T Prehn and Liisa M Prehn

    Citation: Theoretical Biology and Medical Modelling 2013 10:42

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  35. Content type: Research

    Recently, melanoma has become the most malignant and commonly occurring skin cancer. Melanoma is not only the major source (75%) of deaths related to skin cancer, but also it is hard to be treated by the conve...

    Authors: Jun Wang, Le Zhang, Chenyang Jing, Gang Ye, Hulin Wu, Hongyu Miao, Yukun Wu and Xiaobo Zhou

    Citation: Theoretical Biology and Medical Modelling 2013 10:41

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  36. Content type: Research

    In this paper we propose a chemical physics mechanism for the initiation of the glycolytic switch commonly known as the Warburg hypothesis, whereby glycolytic activity terminating in lactate continues even in ...

    Authors: Edward A Rietman, Douglas E Friesen, Philip Hahnfeldt, Robert Gatenby, Lynn Hlatky and Jack A Tuszynski

    Citation: Theoretical Biology and Medical Modelling 2013 10:39

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  37. Content type: Research

    Head and neck cancer (HNC) belongs to a group of heterogeneous disease with distinct patterns of behavior and presentation. TNFRSF10B, a tumor suppressor gene mapped on chromosome 8. Mutation in candidate gene...

    Authors: Rana Adnan Tahir, Sheikh Arslan Sehgal, Naureen Aslam Khattak, Jabar Zaman Khan Khattak and Asif Mir

    Citation: Theoretical Biology and Medical Modelling 2013 10:38

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  38. Content type: Research

    Alpha 1- antitrypsin (α1AT) a 54 kDa glycoprotein is a protease inhibitor. In the absence of α1AT, elastase released by lung macrophages, was not inhibited and lead to elastin breakdown and pulmonary problems ...

    Authors: Nazanin Pirooznia, Sadegh Hasannia, Seyed Shahriar Arab, Abbas Sahebghadam Lotfi, Mostafa Ghanei and Abbas Shali

    Citation: Theoretical Biology and Medical Modelling 2013 10:36

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  39. Content type: Research

    Estimation of leaf productivity in eelgrass (Zostera marina L.) is crucial for evaluating the ecological role of this important seagrass species. Although leaf marking techniques are widely used to obtain estimat...

    Authors: Héctor Echavarría-Heras, Elena Solana-Arellano, Cecilia Leal-Ramírez and Oscar Castillo

    Citation: Theoretical Biology and Medical Modelling 2013 10:34

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  40. Content type: Research

    Despite the rapid advancement of left ventricular assist devices (LVADs), adverse events leading to deaths have been frequently reported in patients implanted with LVADs, including bleeding, infection, thrombo...

    Authors: ChiWei Ong, Socrates Dokos, BeeTing Chan, Einly Lim, Amr Al Abed, NoorAzuanBinAbu Osman, Suhaini Kadiman and Nigel H Lovell

    Citation: Theoretical Biology and Medical Modelling 2013 10:35

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  41. Content type: Research

    Haemodialysis is a form of renal replacement therapy used to treat patients with end stage renal failure. It is becoming more appreciated that haemodialysis patients exhibit higher rates of multiple end organ ...

    Authors: MohamedTarek Eldehni, Aghogho Odudu and ChristopherWilliam McIntyre

    Citation: Theoretical Biology and Medical Modelling 2013 10:33

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  42. Content type: Research

    The resistance of the bone against damage by repairing itself and adapting to environmental conditions is its most important property. These adaptive changes are regulated by physiological process commonly cal...

    Authors: Ahmed Idhammad, Abdelmounaïm Abdali and Noureddine Alaa

    Citation: Theoretical Biology and Medical Modelling 2013 10:32

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  43. Content type: Research

    Knowledge of natural tumour growth is valuable for understanding tumour biology, optimising screening programs, prognostication, optimal scheduling of chemotherapy, and assessing tumour spread. However, mathem...

    Authors: Esmaeil Mehrara, Eva Forssell-Aronsson, Viktor Johanson, Lars Kölby, Ragnar Hultborn and Peter Bernhardt

    Citation: Theoretical Biology and Medical Modelling 2013 10:31

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