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  1. A number of cellular- and molecular-level studies of autophagy assessment have been carried out with the help of various biochemical and morphological indices. Still there exists ambiguity for the assessment o...

    Authors: Kyungreem Han, Jinwoong Kim and Moo Young Choi

    Citation: Theoretical Biology and Medical Modelling 2014 11:31

    Content type: Research

    Published on:

  2. Immunoglobulin (IG) complementarity determining region (CDR) includes VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2 and VL CDR3. Of these, VH CDR3 plays a dominant role in recognizing and binding antigens. Three...

    Authors: Bin Shi, Long Ma, Xiaoyan He, Xiaomei Wang, Peng Wang, Li Zhou and Xinsheng Yao

    Citation: Theoretical Biology and Medical Modelling 2014 11:30

    Content type: Research

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  3. A previous theoretic model (Tumour Biol 2013;34:1–7.) that breast tumor types differ in the relative rate of tissue invasion was elaborated and developed on a consecutive case series.

    Authors: Sven Kurbel, Ksenija Marjanović and Branko Dmitrović

    Citation: Theoretical Biology and Medical Modelling 2014 11:29

    Content type: Research

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  4. In-silico models that attempt to capture and describe the physiological behavior of biological organisms, including humans, are intrinsically complex and time consuming to build and simulate in a computing env...

    Authors: Shaji Krishnan, Mark van Avesaat, Freddy J Troost, Henk FJ Hendriks and Albert A de Graaf

    Citation: Theoretical Biology and Medical Modelling 2014 11:28

    Content type: Research

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  5. The glycoprotein D (gD) is essential for Herpes B virus (BV) entry into mammalian cells. Nectin-1, an HSV-1 gD receptor, is found to be the receptor which mediated BV induced cell-cell fusion, while HVEM does ...

    Authors: Lingke Li, Zhengliang Qiu, Yan Li, Feng Liang, Huahu Ye, Yongqin Cai, Wanfeng Guo, Yan Li and Junjie Yue

    Citation: Theoretical Biology and Medical Modelling 2014 11:27

    Content type: Research

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  6. During plant and animal development, monolayer cell sheets display a stereotyped distribution of polygonal cell shapes. In interphase cells these shapes range from quadrilaterals to decagons, with a robust ave...

    Authors: William T Gibson, Boris Y Rubinstein, Emily J Meyer, James H Veldhuis, G Wayne Brodland, Radhika Nagpal and Matthew C Gibson

    Citation: Theoretical Biology and Medical Modelling 2014 11:26

    Content type: Research

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  7. The purpose of this study was the comparison of the calculated (MLSSC) and experimental power (MLSSE) in maximal lactate steady-state (MLSS) during cycling.

    Authors: Thomas Hauser, Jennifer Adam and Henry Schulz

    Citation: Theoretical Biology and Medical Modelling 2014 11:1

    Content type: Research

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    The Erratum to this article has been published in Theoretical Biology and Medical Modelling 2016 13:18

  8. Haematotoxicity of conventional chemotherapies often results in delays of treatment or reduction of chemotherapy dose. To ameliorate these side-effects, patients are routinely treated with blood transfusions o...

    Authors: Sibylle Schirm, Christoph Engel, Markus Loeffler and Markus Scholz

    Citation: Theoretical Biology and Medical Modelling 2014 11:24

    Content type: Research

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  9. Although the process of endocytosis of the low density lipoprotein (LDL) macromolecule and its receptor have been the subject of intense experimental research and modeling, there are still conflicting hypothes...

    Authors: Héctor Echavarria-Heras, Cecilia Leal-Ramirez and Oscar Castillo

    Citation: Theoretical Biology and Medical Modelling 2014 11:23

    Content type: Research

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  10. Mathematical modeling of virus dynamics has provided quantitative insights into viral infections such as influenza, the simian immunodeficiency virus/human immunodeficiency virus, hepatitis B, and hepatitis C....

    Authors: Hiroki Ikeda, Rob J de Boer, Kei Sato, Satoru Morita, Naoko Misawa, Yoshio Koyanagi, Kazuyuki Aihara and Shingo Iwami

    Citation: Theoretical Biology and Medical Modelling 2014 11:22

    Content type: Research

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  11. Inter-patient variations in tumour growth rate are usually interpreted as biological heterogeneity among patients due to, e.g., genetic variability. However, these variations might be a result of non-exponenti...

    Authors: Esmaeil Mehrara and Eva Forssell-Aronsson

    Citation: Theoretical Biology and Medical Modelling 2014 11:21

    Content type: Research

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  12. Arsenic is a major environmental toxin that is detoxified in the liver by biochemical mechanisms that are still under study. In the traditional metabolic pathway, arsenic undergoes two methylation reactions, e...

    Authors: Sean D Lawley, Jina Yun, Mary V Gamble, Megan N Hall, Michael C Reed and H Frederik Nijhout

    Citation: Theoretical Biology and Medical Modelling 2014 11:20

    Content type: Research

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  13. Computational modeling of Red Blood Cell (RBC) flow contributes to the fundamental understanding of microhemodynamics and microcirculation. In order to construct theoretical RBC models, experimental studies on...

    Authors: Swe Soe Ye, Yan Cheng Ng, Justin Tan, Hwa Liang Leo and Sangho Kim

    Citation: Theoretical Biology and Medical Modelling 2014 11:19

    Content type: Research

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  14. Previously, we suggested prototypal models that describe some clinical states based on group postulates. Here, we demonstrate a group/category theory-like model for molecular/genetic biology as an alternative ...

    Authors: Jitsuki Sawamura, Shigeru Morishita and Jun Ishigooka

    Citation: Theoretical Biology and Medical Modelling 2014 11:18

    Content type: Research

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  15. Epigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be very relevant.

    Authors: Mariama El Baroudi, Dario La Sala, Caterina Cinti and Enrico Capobianco

    Citation: Theoretical Biology and Medical Modelling 2014 11(Suppl 1):S8

    Content type: Research

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    This article is part of a Supplement: Volume 11 Supplement 1

  16. Extracting relevant information from microarray data is a very complex task due to the characteristics of the data sets, as they comprise a large number of features while few samples are generally available. I...

    Authors: Rafael Marcos Luque-Baena, Daniel Urda, Jose Luis Subirats, Leonardo Franco and Jose M Jerez

    Citation: Theoretical Biology and Medical Modelling 2014 11(Suppl 1):S7

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  17. Social media platforms encourage people to share diverse aspects of their daily life. Among these, shared health related information might be used to infer health status and incidence rates for specific condit...

    Authors: José Carlos Santos and Sérgio Matos

    Citation: Theoretical Biology and Medical Modelling 2014 11(Suppl 1):S6

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  18. Networks Biology allows the study of complex interactions between biological systems using formal, well structured, and computationally friendly models. Several different network models can be created, dependi...

    Authors: Alfredo Benso, Stefano Di Carlo, Gianfranco Politano, Alessandro Savino and Alessandro Vasciaveo

    Citation: Theoretical Biology and Medical Modelling 2014 11(Suppl 1):S5

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  19. Surgical interfaces are used for helping surgeons in interpretation and quantification of the patient information, and for the presentation of an integrated workflow where all available data are combined to en...

    Authors: Duygun Erol Barkana and Alper Açık

    Citation: Theoretical Biology and Medical Modelling 2014 11(Suppl 1):S4

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

    The Erratum to this article has been published in Theoretical Biology and Medical Modelling 2014 11:48

  20. Superficial bladder cancer has been the subject of numerous studies for many years, but the evolution of the disease still remains not well understood. After the tumor has been surgically removed, it may reapp...

    Authors: Gregorio Rubio, Belén García-Mora, Cristina Santamaría and José Luis Pontones

    Citation: Theoretical Biology and Medical Modelling 2014 11(Suppl 1):S3

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  21. The identification of polymorphisms and/or genes responsible for an organism's radiosensitivity increases the knowledge about the cell cycle and the mechanism of the phenomena themselves, possibly providing th...

    Authors: Joanna Zyla, Paul Finnon, Robert Bulman, Simon Bouffler, Christophe Badie and Joanna Polanska

    Citation: Theoretical Biology and Medical Modelling 2014 11(Suppl 1):S2

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  22. In this work, we propose the Halo test, a simple visual test based on a freeware software for quantifying and displaying night-vision disturbances perceived by subjects under different experimental conditions,...

    Authors: José J Castro, Carolina Ortiz, Antonio M Pozo, Rosario G Anera and Margarita Soler

    Citation: Theoretical Biology and Medical Modelling 2014 11(Suppl 1):S1

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  23. Metastatic tumors are a major source of morbidity and mortality for most cancers. Interaction of circulating tumor cells with endothelium, platelets and neutrophils play an important role in the early stages o...

    Authors: Abhineet Uppal, Sean C Wightman, Sabha Ganai, Ralph R Weichselbaum and Gary An

    Citation: Theoretical Biology and Medical Modelling 2014 11:17

    Content type: Research

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  24. A brief overview is provided of cosinor-based techniques for the analysis of time series in chronobiology. Conceived as a regression problem, the method is applicable to non-equidistant data, a major advantage...

    Authors: Germaine Cornelissen

    Citation: Theoretical Biology and Medical Modelling 2014 11:16

    Content type: Review

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  25. Temporal lobe epilepsy (TLE) is the commonest type of epilepsy in adults, and the hippocampus is indicated to have a close relationship with TLE. Recent researches also indicate that the entorhinal cortex (EC)...

    Authors: Hui Ren, Ye-Jun Shi, Qin-Chi Lu, Pei-Ji Liang and Pu-Ming Zhang

    Citation: Theoretical Biology and Medical Modelling 2014 11:14

    Content type: Research

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  26. Simple and effective cryopreservation of human oocytes would have an enormous impact on the financial and ethical constraints of human assisted reproduction. Recently, studies have demonstrated the potential f...

    Authors: Allyson Fry Davidson, James D Benson and Adam Z Higgins

    Citation: Theoretical Biology and Medical Modelling 2014 11:13

    Content type: Research

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  27. Nanoscale electrostatic microtubule disassembly forces between positively charged molecules in kinetochores and negative charges on plus ends of microtubules have been implicated in poleward chromosome motions...

    Authors: L John Gagliardi and Daniel H Shain

    Citation: Theoretical Biology and Medical Modelling 2014 11:12

    Content type: Commentary

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  28. The modelling framework is proposed to study protection properties of antibodies to neutralize the effects of the plant toxin (ricin). The present study extends our previous work by including (i) the model of ...

    Authors: Vladas Skakauskas, Pranas Katauskis, Alex Skvortsov and Peter Gray

    Citation: Theoretical Biology and Medical Modelling 2014 11:11

    Content type: Research

    Published on:

  29. Since cell membranes are weak sources of electrostatic fields, this ECG interpretation relies on the analogy between cells and electrets. It is here assumed that cell-bound electric fields unite, reach the bod...

    Authors: Sven Kurbel

    Citation: Theoretical Biology and Medical Modelling 2014 11:10

    Content type: Review

    Published on:

  30. Transmission dynamic models linked to economic analyses often form part of the decision making process when introducing new chlamydia screening interventions. Outputs from these transmission dynamic models can...

    Authors: Bethan Davies, Sarah-Jane Anderson, Katy ME Turner and Helen Ward

    Citation: Theoretical Biology and Medical Modelling 2014 11:8

    Content type: Review

    Published on:

  31. Alan Turing’s work in Morphogenesis has received wide attention during the past 60 years. The central idea behind his theory is that two chemically interacting diffusible substances are able to generate stable...

    Authors: Tatiana T Marquez-Lago and Pablo Padilla

    Citation: Theoretical Biology and Medical Modelling 2014 11:7

    Content type: Research

    Published on:

  32. Adverse remodeling of the left ventricle (LV) following myocardial infarction (MI) leads to heart failure. Recent studies have shown that scar anisotropy is a determinant of cardiac function post-MI, however i...

    Authors: Andrew P Voorhees and Hai-Chao Han

    Citation: Theoretical Biology and Medical Modelling 2014 11:6

    Content type: Research

    Published on:

  33. There has been a variation in published opinions toward the effectiveness of school closure which is implemented reactively when substantial influenza transmissions are seen at schools. Parameterizing an age-s...

    Authors: Hiroshi Nishiura, Keisuke Ejima, Kenji Mizumoto, Shinji Nakaoka, Hisashi Inaba, Seiya Imoto, Rui Yamaguchi and Masaya M Saito

    Citation: Theoretical Biology and Medical Modelling 2014 11:5

    Content type: Research

    Published on:

  34. Hematopoiesis is a complex process that encompasses both pro-mitotic and anti-mitotic stimuli. Pharmacological agents used in chemotherapy have a prominent anti-mitotic effect. The approach of inhibiting cell ...

    Authors: Christina L Mouser, Eliana S Antoniou, James Tadros and Evros K Vassiliou

    Citation: Theoretical Biology and Medical Modelling 2014 11:4

    Content type: Research

    Published on:

  35. Determining the pandemic potential of an emerging infectious disease and how it depends on the various epidemic and population aspects is critical for the preparation of an adequate response aimed at its contr...

    Authors: Andrea Apolloni, Chiara Poletto, José J Ramasco, Pablo Jensen and Vittoria Colizza

    Citation: Theoretical Biology and Medical Modelling 2014 11:3

    Content type: Research

    Published on:

  36. Codon degeneracy and codon usage by organisms is an interesting and challenging problem. Researchers demonstrated the relation between codon usage and various functions or properties of genes and proteins, suc...

    Authors: Mohammad-Hadi Foroughmand-Araabi, Bahram Goliaei, Kasra Alishahi and Mehdi Sadeghi

    Citation: Theoretical Biology and Medical Modelling 2014 11:2

    Content type: Research

    Published on:

  37. Understanding how developmental systems evolve over time is a key question in stem cell and developmental biology research. However, due to hurdles of existing experimental techniques, our understanding of the...

    Authors: Yaki Setty

    Citation: Theoretical Biology and Medical Modelling 2014 11:1

    Content type: Review

    Published on:

  38. When anti-tumour therapy is administered to a tumour-host environment, an asymptotic tapering extremity of the tumour cell distribution is noticed. This extremity harbors a small number of residual tumour cell...

    Authors: Suhela Kapoor, VP Subramanyam Rallabandi, Chandrashekhar Sakode, Radhakant Padhi and Prasun K Roy

    Citation: Theoretical Biology and Medical Modelling 2013 10:68

    Content type: Research

    Published on:

  39. Abdominal aortic aneurysms (AAA) are currently being treated based on the maximum diameter criterion which has often been proven insufficient to determine rupture risk in case of every AAA. We analyzed a rare ...

    Authors: Nikolaos Kontopodis, Eleni Metaxa, Yannis Papaharilaou, Efstratios Georgakarakos, Dimitrios Tsetis and Christos V Ioannou

    Citation: Theoretical Biology and Medical Modelling 2013 10:67

    Content type: Research

    Published on:

  40. Normal colon crypts consist of stem cells, proliferating cells, and differentiated cells. Abnormal rates of proliferation and differentiation can initiate colon cancer. We have measured the variation in the nu...

    Authors: Rafael Bravo and David E Axelrod

    Citation: Theoretical Biology and Medical Modelling 2013 10:66

    Content type: Software

    Published on:

  41. The hypothalamic-pituitary-adrenal axis (HPA axis) is a major part of the neuroendocrine system responsible for the regulation of the response to physical or mental stress and for the control of the synthesis ...

    Authors: Clemens A Zarzer, Martin G Puchinger, Gottfried Köhler and Philipp Kügler

    Citation: Theoretical Biology and Medical Modelling 2013 10:65

    Content type: Research

    Published on:

  42. Classical mechanical dilators for cervical dilation are associated with various complications, such as uterine perforation, cervical laceration, infections and intraperitoneal hemorrhage. A new medical device ...

    Authors: Nenad Filipovic, Dalibor Nikolic, Igor Saveljic, Irena Tanaskovic, Nebojsa Zdravkovic, Aleksandar Zivanovic, Petar Arsenijevic, Branislav Jeremic and Slobodan Arsenijevic

    Citation: Theoretical Biology and Medical Modelling 2013 10:64

    Content type: Research

    Published on:

  43. N-Acetylserotonin O-methyltransferase (ASMT) is an enzyme which by converting nor-melatonin to melatonin catalyzes the final reaction in melatonin biosynthesis in tryptophan metabolism pathway. High Expression...

    Authors: Syed Sikander Azam and Sumra Wajid Abbasi

    Citation: Theoretical Biology and Medical Modelling 2013 10:63

    Content type: Research

    Published on:

  44. The criteria for organ sharing has developed a system that prioritizes liver transplantation (LT) for patients with hepatocellular carcinoma (HCC) who have the highest risk of wait-list mortality. In some coun...

    Authors: Eleazar Chaib, Marcos Amaku, Francisco AB Coutinho, Luis F Lopez, Marcelo N Burattini, Luiz AC D’Albuquerque and Eduardo Massad

    Citation: Theoretical Biology and Medical Modelling 2013 10:60

    Content type: Research

    Published on:

  45. Major depressive disorder (MDD) is a multifactorial disorder known to be influenced by both genetic and environmental factors. MDD presents a heritability of 37%, and a genetic contribution has also been obser...

    Authors: Oscar Andrés Moreno-Ramos, Maria Claudia Lattig and Andrés Fernando González Barrios

    Citation: Theoretical Biology and Medical Modelling 2013 10:59

    Content type: Research

    Published on:

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