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  1. There are various methods for predicting human pharmacokinetics. Among these, a whole body physiologically-based pharmacokinetic (WBPBPK) model is useful because it gives a mechanistic description. However, WB...

    Authors: Hirotaka Ando, Shigeru Izawa, Wataru Hori and Ippei Nakagawa

    Citation: Theoretical Biology and Medical Modelling 2008 5:19

    Content type: Research

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    The Erratum to this article has been published in Theoretical Biology and Medical Modelling 2009 6:29

  2. Herpes Simplex virus types 1 and 2 are enveloped viruses with a linear dsDNA genome of ~120–200 kb. Genital infection with HSV-2 has been denoted as a major risk factor for acquisition and transmission of HIV-...

    Authors: Misaki Wayengera, Henry Kajumbula and Wilson Byarugaba

    Citation: Theoretical Biology and Medical Modelling 2008 5:18

    Content type: Research

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  3. Insulin, the principal regulating hormone of blood glucose, is released through the bursting of the pancreatic islets. Increasing evidence indicates the importance of islet morphostructure in its function, and...

    Authors: Aparna Nittala and Xujing Wang

    Citation: Theoretical Biology and Medical Modelling 2008 5:17

    Content type: Research

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  4. There is a 3-fold redundancy in the Genetic Code; most amino acids are encoded by more than one codon. These synonymous codons are not used equally; there is a Codon Usage Bias (CUB). This article will provide...

    Authors: Jan C Biro

    Citation: Theoretical Biology and Medical Modelling 2008 5:16

    Content type: Research

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  5. Carcinogenesis is commonly described as a multistage process, in which stem cells are transformed into cancer cells via a series of mutations. In this article, we consider extensions of the multistage carcinog...

    Authors: Sandro Gsteiger and Stephan Morgenthaler

    Citation: Theoretical Biology and Medical Modelling 2008 5:13

    Content type: Research

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  6. Several fractal and non-fractal parameters have been considered for the quantitative assessment of the vascular architecture, using a variety of test specimens and of computational tools. The fractal parameter...

    Authors: Daniele Mancardi, Gianfranco Varetto, Enrico Bucci, Fabrizio Maniero and Caterina Guiot

    Citation: Theoretical Biology and Medical Modelling 2008 5:12

    Content type: Commentary

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  7. Research in the last fifty years has shown that many autistic individuals have elevated serotonin (5-hydroxytryptamine, 5-HT) levels in blood platelets. This phenomenon, known as the platelet hyperserotonemia ...

    Authors: Skirmantas Janušonis

    Citation: Theoretical Biology and Medical Modelling 2008 5:10

    Content type: Research

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  8. The comprehension of the gene regulatory code in eukaryotes is one of the major challenges of systems biology, and is a requirement for the development of novel therapeutic strategies for multifactorial diseas...

    Authors: Annick Lesne and Arndt Benecke

    Citation: Theoretical Biology and Medical Modelling 2008 5:9

    Content type: Research

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  9. Glutathione (GSH) plays an important role in anti-oxidant defense and detoxification reactions. It is primarily synthesized in the liver by the transsulfuration pathway and exported to provide precursors for i...

    Authors: Michael C Reed, Rachel L Thomas, Jovana Pavisic, S Jill James, Cornelia M Ulrich and H Frederik Nijhout

    Citation: Theoretical Biology and Medical Modelling 2008 5:8

    Content type: Research

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  10. The Phenomenological Universalities approach has been developed by P.P. Delsanto and collaborators during the past 2–3 years. It represents a new tool for the analysis of experimental datasets and cross-fertil...

    Authors: Pier Paolo Delsanto, Antonio S Gliozzi and Caterina Guiot

    Citation: Theoretical Biology and Medical Modelling 2008 5:5

    Content type: Research

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  11. In hemodialysis patients, the most common cause of vascular access failure is neointimal hyperplasia of vascular smooth muscle cells at the venous anastomosis of arteriovenous fistulas and grafts. The release ...

    Authors: Paula Budu-Grajdeanu, Richard C Schugart, Avner Friedman, Christopher Valentine, Anil K Agarwal and Brad H Rovin

    Citation: Theoretical Biology and Medical Modelling 2008 5:2

    Content type: Research

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  12. Genetic and environmental agents that disrupt organogenesis are numerous and well described. Less well established, however, is the role of delay in the developmental processes that yield functionally immature...

    Authors: J Craig Cohen and Janet E Larson

    Citation: Theoretical Biology and Medical Modelling 2008 5:1

    Content type: Review

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  13. The epidermal growth factor receptor (EGFR) is frequently overexpressed in many cancers, including non-small cell lung cancer (NSCLC). In silico modeling is considered to be an increasingly promising tool to add ...

    Authors: Zhihui Wang, Le Zhang, Jonathan Sagotsky and Thomas S Deisboeck

    Citation: Theoretical Biology and Medical Modelling 2007 4:50

    Content type: Research

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  14. The desire to better understand the immuno-biology of infectious diseases as a broader ecological system has motivated the explicit representation of epidemiological processes as a function of immune system dy...

    Authors: David M Vickers and Nathaniel D Osgood

    Citation: Theoretical Biology and Medical Modelling 2007 4:49

    Content type: Research

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  15. It is a daunting task to identify all the metabolic pathways of brain energy metabolism and develop a dynamic simulation environment that will cover a time scale ranging from seconds to hours. To simplify this...

    Authors: Tunahan Çakιr, Selma Alsan, Hale Saybaşιlι, Ata Akιn and Kutlu Ö Ülgen

    Citation: Theoretical Biology and Medical Modelling 2007 4:48

    Content type: Research

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  16. Abel and Trevors have delineated three aspects of sequence complexity, Random Sequence Complexity (RSC), Ordered Sequence Complexity (OSC) and Functional Sequence Complexity (FSC) observed in biosequences such...

    Authors: Kirk K Durston, David KY Chiu, David L Abel and Jack T Trevors

    Citation: Theoretical Biology and Medical Modelling 2007 4:47

    Content type: Research

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  17. A significant body of literature is devoted to modeling developmental mechanisms that create patterns within groups of initially equivalent embryonic cells. Although it is clear that these mechanisms do not fu...

    Authors: Gregory J Podgorski, Mayank Bansal and Nicholas S Flann

    Citation: Theoretical Biology and Medical Modelling 2007 4:43

    Content type: Research

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  18. The diauxic shift in yeast requires cells to coordinate a complicated response that involves numerous genes and metabolic processes. It is unknown whether responses of this type are mediated in vivo through chang...

    Authors: Fernando Alvarez-Vasquez, Kellie J Sims, Eberhard O Voit and Yusuf A Hannun

    Citation: Theoretical Biology and Medical Modelling 2007 4:42

    Content type: Research

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  19. Despite a prodigious investment of funds, we cannot treat or prevent arteriosclerosis and restenosis, particularly its major pathology, arterial intimal hyperplasia. A cornerstone question lies behind all appr...

    Authors: Vladimir M Subbotin

    Citation: Theoretical Biology and Medical Modelling 2007 4:41

    Content type: Research

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  20. A new two-parameter probability distribution called hypertabastic is introduced to model the survival or time-to-event data. A simulation study was carried out to evaluate the performance of the hypertabastic ...

    Authors: Mohammad A Tabatabai, Zoran Bursac, David K Williams and Karan P Singh

    Citation: Theoretical Biology and Medical Modelling 2007 4:40

    Content type: Research

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  21. We introduce the Basic Immune Simulator (BIS), an agent-based model created to study the interactions between the cells of the innate and adaptive immune system. Innate immunity, the initial host response to a...

    Authors: Virginia A Folcik, Gary C An and Charles G Orosz

    Citation: Theoretical Biology and Medical Modelling 2007 4:39

    Content type: Software

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  22. In the past, tasks of model based yield optimization in metabolic engineering were either approached with stoichiometric models or with structured nonlinear models such as S-systems or linear-logarithmic repre...

    Authors: Alberto Marin-Sanguino, Eberhard O Voit, Carlos Gonzalez-Alcon and Nestor V Torres

    Citation: Theoretical Biology and Medical Modelling 2007 4:38

    Content type: Research

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  23. The Differential Adhesion Hypothesis (DAH) is a theory of the organization of cells within a tissue which has been validated by several biological experiments and tested against several alternative computation...

    Authors: Mathieu Emily and Olivier François

    Citation: Theoretical Biology and Medical Modelling 2007 4:37

    Content type: Research

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  24. Propagation of simulated action potentials (APs) was previously studied in short single chains and in two-dimensional sheets of myocardial cells [13]. The present study was undertaken to examine propagation in a...

    Authors: Lakshminarayanan Ramasamy and Nicholas Sperelakis

    Citation: Theoretical Biology and Medical Modelling 2007 4:36

    Content type: Research

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  25. Multidrug resistance is a particular limitation to cancer chemotherapy, antibiotic treatment and HIV medication. The ABC (ATP binding cassette) transporters human P-glycoprotein (ABCB1) and the human MRP5 (ABC...

    Authors: Aina W Ravna, Ingebrigt Sylte and Georg Sager

    Citation: Theoretical Biology and Medical Modelling 2007 4:33

    Content type: Research

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  26. A recent model describing the mechanical interaction between a stenosis and the vessel wall has shown that axial wall stress can considerably increase in the region immediately proximal to the stenosis during ...

    Authors: Pierre-André Doriot, Pierre-André Dorsaz and Jacques Noble

    Citation: Theoretical Biology and Medical Modelling 2007 4:29

    Content type: Research

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  27. The flow cytometry analysis of CFSE-labelled cells is currently one of the most informative experimental techniques for studying cell proliferation in immunology. The quantitative interpretation and understand...

    Authors: Tatyana Luzyanina, Dirk Roose, Tim Schenkel, Martina Sester, Stephan Ehl, Andreas Meyerhans and Gennady Bocharov

    Citation: Theoretical Biology and Medical Modelling 2007 4:26

    Content type: Research

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  28. Current methods for quantifying effects of DNA repair modifiers on radiation sensitivity assume a constant effect independent of the radiation dose received. The aim of this study was to develop and evaluate a...

    Authors: Anthony J Chalmers, Soeren M Bentzen and Francesca M Buffa

    Citation: Theoretical Biology and Medical Modelling 2007 4:25

    Content type: Research

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  29. Train-of-four stimulation pattern following the administration of non-depolarizing neuromuscular blocking drugs reveals fade on successive contractions. Fade is caused by the release of fewer acetylcholine mol...

    Authors: Shashi B Bhatt, Jack Kohl, Anton Amann and Vladimir Nigrovic

    Citation: Theoretical Biology and Medical Modelling 2007 4:24

    Content type: Research

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  30. The diagnosis, treatment and prevention of osteoporosis is a national health emergency. Osteoporosis quietly progresses without symptoms until late stage complications occur. Older patients are more commonly a...

    Authors: Babak Mohammadi, Vahid Haghpanah, Seyed Mohammad Tavangar and Bagher Larijani

    Citation: Theoretical Biology and Medical Modelling 2007 4:23

    Content type: Research

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  31. Dendrites are the most conspicuous feature of neurons. However, the principles determining their structure are poorly understood. By employing cable theory and, for the first time, graph theory, we describe de...

    Authors: Hermann Cuntz, Alexander Borst and Idan Segev

    Citation: Theoretical Biology and Medical Modelling 2007 4:21

    Content type: Research

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