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  6. Oncogene signaling is known to deregulate cell proliferation resulting in uncontrolled growth and cellular transformation. Gene amplification and/or somatic mutations of the HER2/Neu (ErbB2) proto-oncogene occ...

    Authors: Peter Hinow, Shizhen Emily Wang, Carlos L Arteaga and Glenn F Webb

    Citation: Theoretical Biology and Medical Modelling 2007 4:14

    Content type: Research

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  7. Drug-drug interactions resulting from the inhibition of an enzymatic process can have serious implications for clinical drug therapy. Quantification of the drugs internal exposure increase upon administration ...

    Authors: Michaela Vossen, Michael Sevestre, Christoph Niederalt, In-Jin Jang, Stefan Willmann and Andrea N Edginton

    Citation: Theoretical Biology and Medical Modelling 2007 4:13

    Content type: Research

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  9. Development of the mathematical models that adequately describe biochemical reactions and molecular-genetic mechanisms is one of the most important tasks in modern bioinformatics. Because the enzyme adenylosuc...

    Authors: Evgeniya A Oshchepkova-Nedosekina and Vitalii A Likhoshvai

    Citation: Theoretical Biology and Medical Modelling 2007 4:11

    Content type: Research

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  10. We address themes of distributed cognition by extending recent formal developments in the theory of individual consciousness. While single minds appear biologically limited to one dynamic structure of linked c...

    Authors: Rodrick M Wallace, Mindy T Fullilove, Robert E Fullilove and Deborah N Wallace

    Citation: Theoretical Biology and Medical Modelling 2007 4:10

    Content type: Research

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  12. The body's primary stress management system is the hypothalamic pituitary adrenal (HPA) axis. The HPA axis responds to physical and mental challenge to maintain homeostasis in part by controlling the body's co...

    Authors: Shakti Gupta, Eric Aslakson, Brian M Gurbaxani and Suzanne D Vernon

    Citation: Theoretical Biology and Medical Modelling 2007 4:8

    Content type: Research

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  15. Genes that control circadian rhythms in organisms have been recognized, but have been difficult to detect because circadian behavior comprises periodically dynamic traits and is sensitive to environmental chan...

    Authors: Tian Liu, Xueli Liu, Yunmei Chen and Rongling Wu

    Citation: Theoretical Biology and Medical Modelling 2007 4:5

    Content type: Research

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  18. Chemotactic movement is a common feature of many cells and microscopic organisms. In vivo, chemotactic cells have to follow a chemotactic gradient and simultaneously avoid the numerous obstacles present in their ...

    Authors: Ramon Grima

    Citation: Theoretical Biology and Medical Modelling 2007 4:2

    Content type: Research

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  19. Circadian rhythms with varying components exist in organisms ranging from humans to cyanobacteria. A simple evolutionarily plausible mechanism for the origin of such a variety of circadian oscillators, propose...

    Authors: Roderick Edwards, Richard Gibson, Reinhard Illner and Verner Paetkau

    Citation: Theoretical Biology and Medical Modelling 2007 4:1

    Content type: Research

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  20. Most theories about cancer proposed during the last century share a common denominator: cancer is believed to be a biological nonsense for the organism in which it originates, since cancer cells are believed to b...

    Authors: Raúl A Ruggiero and Oscar D Bustuoabad

    Citation: Theoretical Biology and Medical Modelling 2006 3:43

    Content type: Research

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  23. In eukaryotes, folate metabolism is compartmentalized and occurs in both the cytosol and the mitochondria. The function of this compartmentalization and the great changes that occur in the mitochondrial compar...

    Authors: H Frederik Nijhout, Michael C Reed, Shi-Ling Lam, Barry Shane, Jesse F Gregory III and Cornelia M Ulrich

    Citation: Theoretical Biology and Medical Modelling 2006 3:40

    Content type: Research

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  24. In a mammalian auditory system, when intrinsic noise is added to a subthreshold signal, not only can the resulting noisy signal be detected, but also the information carried by the signal can be completely rec...

    Authors: Dawei Hong, Joseph V Martin and William M Saidel

    Citation: Theoretical Biology and Medical Modelling 2006 3:39

    Content type: Research

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  26. Cancer remains one of the most complex diseases affecting humans and, despite the impressive advances that have been made in molecular and cell biology, how cancer cells progress through carcinogenesis and acq...

    Authors: Fabio Grizzi, Antonio Di Ieva, Carlo Russo, Eldo E Frezza, Everardo Cobos, Pier Carlo Muzzio and Maurizio Chiriva-Internati

    Citation: Theoretical Biology and Medical Modelling 2006 3:37

    Content type: Commentary

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  27. Quantification of in-vivo biomolecule mass transport and reaction rate parameters from experimental data obtained by Fluorescence Recovery after Photobleaching (FRAP) is becoming more important.

    Authors: Kouroush Sadegh Zadeh, Hubert J Montas and Adel Shirmohammadi

    Citation: Theoretical Biology and Medical Modelling 2006 3:36

    Content type: Research

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  28. The potential public health benefits of targeting environmental interventions by genotype depend on the environmental and genetic contributions to the variance of common diseases, and the magnitude of any gene...

    Authors: Helen M Wallace

    Citation: Theoretical Biology and Medical Modelling 2006 3:35

    Content type: Research

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  29. Developing countries have high prevalence of diseases, but facilities to diagnose and treat them are limited. We must use available resources in ways not needed where there are sophisticated equipment and trai...

    Authors: Alan E Dugdale

    Citation: Theoretical Biology and Medical Modelling 2006 3:34

    Content type: Research

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  30. Regular, "moderate", physical exercise is an established non-pharmacological form of treatment for depressive disorders. Brain lateralization has a significant role in the progress of depression. External stim...

    Authors: Suptendra N Sarbadhikari and Asit K Saha

    Citation: Theoretical Biology and Medical Modelling 2006 3:33

    Content type: Research

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  32. Murray's Law states that, when a parent blood vessel branches into daughter vessels, the cube of the radius of the parent vessel is equal to the sum of the cubes of the radii of daughter blood vessels. Murray ...

    Authors: Page R Painter, Patrik Edén and Hans-Uno Bengtsson

    Citation: Theoretical Biology and Medical Modelling 2006 3:31

    Content type: Research

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  33. CapZ is a calcium-insensitive and lipid-dependent actin filament capping protein, the main function of which is to regulate the assembly of the actin cytoskeleton. CapZ is associated with membranes in cells an...

    Authors: James Smith, Gerold Diez, Anna H Klemm, Vitali Schewkunow and Wolfgang H Goldmann

    Citation: Theoretical Biology and Medical Modelling 2006 3:30

    Content type: Research

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  35. All the information necessary for protein folding is supposed to be present in the amino acid sequence. It is still not possible to provide specific ab initio structure predictions by bioinformatical methods. It ...

    Authors: Jan Charles Biro

    Citation: Theoretical Biology and Medical Modelling 2006 3:28

    Content type: Research

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  36. Targeting persistent tubercule bacilli has become an important challenge in the development of anti-tuberculous drugs. As the glyoxylate bypass is essential for persistent bacilli, interference with it holds t...

    Authors: Vivek Kumar Singh and Indira Ghosh

    Citation: Theoretical Biology and Medical Modelling 2006 3:27

    Content type: Research

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  39. In order to improve understanding of metabolic systems there have been attempts to construct S-system models from time courses. Conventionally, non-linear curve-fitting algorithms have been used for modelling,...

    Authors: Tomoya Kitayama, Ayako Kinoshita, Masahiro Sugimoto, Yoichi Nakayama and Masaru Tomita

    Citation: Theoretical Biology and Medical Modelling 2006 3:24

    Content type: Research

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  40. There is a vast and contradictory literature concerning the effect of the spleen and particularly of splenectomy on tumor growth. Sometimes splenectomy seems to inhibit tumor growth, but in other cases it seem...

    Authors: Richmond T Prehn

    Citation: Theoretical Biology and Medical Modelling 2006 3:23

    Content type: Review

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  41. Despite great advances in clinical oncology, the molecular mechanisms underlying the failure of chemotherapeutic intervention in treating lymphoproliferative and related disorders are not well understood.

    Authors: Subburaj Kannan

    Citation: Theoretical Biology and Medical Modelling 2006 3:22

    Content type: Research

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  42. The purpose of this paper is two-fold. The first objective is to validate the assumptions behind a stochastic model developed earlier by these authors to describe oligodendrocyte generation in cell culture. Th...

    Authors: Ollivier Hyrien, Ibro Ambeskovic, Margot Mayer-Proschel, Mark Noble and Andrei Yakovlev

    Citation: Theoretical Biology and Medical Modelling 2006 3:21

    Content type: Research

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  44. Alternative splicing of pre-messenger RNA results in RNA variants with combinations of selected exons. It is one of the essential biological functions and regulatory components in higher eukaryotic cells. Some...

    Authors: Wenhong Fan, Najma Khalid, Andrew R Hallahan, James M Olson and Lue Ping Zhao

    Citation: Theoretical Biology and Medical Modelling 2006 3:19

    Content type: Research

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  45. Eukaryotic gene transcription is believed to occur in either a binary or a graded fashion. With binary induction, a transcription activator (TA) regulates the probability with which a gene template is switched...

    Authors: Qiang Zhang, Melvin E Andersen and Rory B Conolly

    Citation: Theoretical Biology and Medical Modelling 2006 3:18

    Content type: Research

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  46. Over the past decade our laboratory has focused on understanding how soluble cytoskeleton-associated proteins interact with membranes and other lipid aggregates. Many protein domains mediating specific cell me...

    Authors: David L Scott, Gerold Diez and Wolfgang H Goldmann

    Citation: Theoretical Biology and Medical Modelling 2006 3:17

    Content type: Review

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  47. There is considerable controversy concerning the exact growth profile of size parameters during the cell cycle. Linear, exponential and bilinear models are commonly considered, and the same model may not apply...

    Authors: Peter Buchwald and Akos Sveiczer

    Citation: Theoretical Biology and Medical Modelling 2006 3:16

    Content type: Research

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  49. In previous PSpice modeling studies of simulated action potentials (APs) in parallel chains of cardiac muscle, it was found that transverse propagation could occur between adjacent chains in the absence of gap...

    Authors: Lakshminarayanan Ramasamy and Nicholas Sperelakis

    Citation: Theoretical Biology and Medical Modelling 2006 3:14

    Content type: Research

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682