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  1. Murray's Law states that, when a parent blood vessel branches into daughter vessels, the cube of the radius of the parent vessel is equal to the sum of the cubes of the radii of daughter blood vessels. Murray ...

    Authors: Page R Painter, Patrik Edén and Hans-Uno Bengtsson
    Citation: Theoretical Biology and Medical Modelling 2006 3:31
  2. CapZ is a calcium-insensitive and lipid-dependent actin filament capping protein, the main function of which is to regulate the assembly of the actin cytoskeleton. CapZ is associated with membranes in cells an...

    Authors: James Smith, Gerold Diez, Anna H Klemm, Vitali Schewkunow and Wolfgang H Goldmann
    Citation: Theoretical Biology and Medical Modelling 2006 3:30
  3. All the information necessary for protein folding is supposed to be present in the amino acid sequence. It is still not possible to provide specific ab initio structure predictions by bioinformatical methods. It ...

    Authors: Jan Charles Biro
    Citation: Theoretical Biology and Medical Modelling 2006 3:28
  4. Targeting persistent tubercule bacilli has become an important challenge in the development of anti-tuberculous drugs. As the glyoxylate bypass is essential for persistent bacilli, interference with it holds t...

    Authors: Vivek Kumar Singh and Indira Ghosh
    Citation: Theoretical Biology and Medical Modelling 2006 3:27
  5. In order to improve understanding of metabolic systems there have been attempts to construct S-system models from time courses. Conventionally, non-linear curve-fitting algorithms have been used for modelling,...

    Authors: Tomoya Kitayama, Ayako Kinoshita, Masahiro Sugimoto, Yoichi Nakayama and Masaru Tomita
    Citation: Theoretical Biology and Medical Modelling 2006 3:24
  6. There is a vast and contradictory literature concerning the effect of the spleen and particularly of splenectomy on tumor growth. Sometimes splenectomy seems to inhibit tumor growth, but in other cases it seem...

    Authors: Richmond T Prehn
    Citation: Theoretical Biology and Medical Modelling 2006 3:23
  7. Despite great advances in clinical oncology, the molecular mechanisms underlying the failure of chemotherapeutic intervention in treating lymphoproliferative and related disorders are not well understood.

    Authors: Subburaj Kannan
    Citation: Theoretical Biology and Medical Modelling 2006 3:22
  8. The purpose of this paper is two-fold. The first objective is to validate the assumptions behind a stochastic model developed earlier by these authors to describe oligodendrocyte generation in cell culture. Th...

    Authors: Ollivier Hyrien, Ibro Ambeskovic, Margot Mayer-Proschel, Mark Noble and Andrei Yakovlev
    Citation: Theoretical Biology and Medical Modelling 2006 3:21
  9. Alternative splicing of pre-messenger RNA results in RNA variants with combinations of selected exons. It is one of the essential biological functions and regulatory components in higher eukaryotic cells. Some...

    Authors: Wenhong Fan, Najma Khalid, Andrew R Hallahan, James M Olson and Lue Ping Zhao
    Citation: Theoretical Biology and Medical Modelling 2006 3:19
  10. Eukaryotic gene transcription is believed to occur in either a binary or a graded fashion. With binary induction, a transcription activator (TA) regulates the probability with which a gene template is switched...

    Authors: Qiang Zhang, Melvin E Andersen and Rory B Conolly
    Citation: Theoretical Biology and Medical Modelling 2006 3:18
  11. Over the past decade our laboratory has focused on understanding how soluble cytoskeleton-associated proteins interact with membranes and other lipid aggregates. Many protein domains mediating specific cell me...

    Authors: David L Scott, Gerold Diez and Wolfgang H Goldmann
    Citation: Theoretical Biology and Medical Modelling 2006 3:17
  12. There is considerable controversy concerning the exact growth profile of size parameters during the cell cycle. Linear, exponential and bilinear models are commonly considered, and the same model may not apply...

    Authors: Peter Buchwald and Akos Sveiczer
    Citation: Theoretical Biology and Medical Modelling 2006 3:16
  13. In previous PSpice modeling studies of simulated action potentials (APs) in parallel chains of cardiac muscle, it was found that transverse propagation could occur between adjacent chains in the absence of gap...

    Authors: Lakshminarayanan Ramasamy and Nicholas Sperelakis
    Citation: Theoretical Biology and Medical Modelling 2006 3:14
  14. It is commonly accepted that embryonic segmentation of vertebrates is regulated by a segmentation clock, which is induced by the cycling genes Hes1 and Hes7. Their products form dimers that bind to the regulatory...

    Authors: Stefan Zeiser, H Volkmar Liebscher, Hendrik Tiedemann, Isabel Rubio-Aliaga, Gerhard KH Przemeck, Martin Hrabé de Angelis and Gerhard Winkler
    Citation: Theoretical Biology and Medical Modelling 2006 3:11
  15. Two approaches to understanding growth during the cell cycle are single-cell studies, where growth during the cell cycle of a single cell is measured, and cell-culture studies, where growth during the cell cyc...

    Authors: Stephen Cooper
    Citation: Theoretical Biology and Medical Modelling 2006 3:10
  16. Sepsis (bloodstream infection) is the leading cause of death in non-surgical intensive care units. It is diagnosed in 750,000 US patients per annum, and has high mortality. Current understanding of sepsis is p...

    Authors: Sergey M Zuev, Stephen F Kingsmore and Damian DG Gessler
    Citation: Theoretical Biology and Medical Modelling 2006 3:8
  17. The hypothesis of immunosurveillance suggests that new neoplasms arise very frequently, but most are destroyed almost at their inception by an immune response. Its correctness has been debated for many years.

    Authors: Richmond T Prehn
    Citation: Theoretical Biology and Medical Modelling 2006 3:6
  18. A national chlamydia screening programme is currently being rolled out in the UK and other countries. However, much of the epidemiology remains poorly understood. In this paper we present a stochastic, individ...

    Authors: Katherine ME Turner, Elisabeth J Adams, Nigel Gay, Azra C Ghani, Catherine Mercer and W John Edmunds
    Citation: Theoretical Biology and Medical Modelling 2006 3:3
  19. Recent work has indicated an increasingly complex role for astrocytes in the central nervous system. Astrocytes are now known to exchange information with neurons at synaptic junctions and to alter the informa...

    Authors: Robert M Caudle
    Citation: Theoretical Biology and Medical Modelling 2006 3:2
  20. There have been indications that common Angiotensin Receptor Blockers (ARBs) may be exerting anti-inflammatory actions by directly modulating the immune system. We decided to use molecular modelling to rapidly...

    Authors: Trevor G Marshall, Robert E Lee and Frances E Marshall
    Citation: Theoretical Biology and Medical Modelling 2006 3:1
  21. Attention Deficit Hyperactivity Disorder, commonly referred to as ADHD, is a common, complex, predominately genetic but highly treatable disorder, which in its more severe form has such a profound effect on br...

    Authors: David E Comings, Thomas JH Chen, Kenneth Blum, Julie F Mengucci, Seth H Blum and Brian Meshkin
    Citation: Theoretical Biology and Medical Modelling 2005 2:50
  22. Recent developments in Global Workspace theory suggest that human consciousness can suffer interpenetrating dysfunctions of mutual and reciprocal interaction with embedding environments which will have early o...

    Authors: Rodrick Wallace
    Citation: Theoretical Biology and Medical Modelling 2005 2:49
  23. In previous studies on propagation of simulated action potentials (APs) in cardiac muscle using PSpice modeling, we reported that a second black-box (BB) could not be inserted into the K+ leg of the basic membran...

    Authors: Lakshminarayanan Ramasamy and Nicholas Sperelakis
    Citation: Theoretical Biology and Medical Modelling 2005 2:48
  24. The paper of Liu, Gaido and Wolfinger on gene expression during the division cycle of HeLa cells using the data of Whitfield et al. are discussed in order to see whether their analysis is related to gene expre...

    Authors: Stephen Cooper
    Citation: Theoretical Biology and Medical Modelling 2005 2:47
  25. Variation in gene expression among cells in a population is often considered as noise produced from gene transcription and post-transcription processes and experimental artifacts. Most studies on noise in gene...

    Authors: Delong Liu, Kevin W Gaido and Russ Wolfinger
    Citation: Theoretical Biology and Medical Modelling 2005 2:46
  26. The Euglycemic Hyperinsulinemic Clamp (EHC) is the most widely used experimental procedure for the determination of insulin sensitivity, and in its usual form the patient is followed under insulinization for t...

    Authors: Umberto Picchini, Andrea De Gaetano, Simona Panunzi, Susanne Ditlevsen and Geltrude Mingrone
    Citation: Theoretical Biology and Medical Modelling 2005 2:44
  27. Many computer studies have employed either dynamic simulation or metabolic flux analysis (MFA) to predict the behaviour of biochemical pathways. Dynamic simulation determines the time evolution of pathway prop...

    Authors: Katsuyuki Yugi, Yoichi Nakayama, Ayako Kinoshita and Masaru Tomita
    Citation: Theoretical Biology and Medical Modelling 2005 2:42
  28. Formal description of a cell's genetic information should provide the number of DNA molecules in that cell and their complete nucleotide sequences. We pose the formal problem: can the genome sequence forming t...

    Authors: Pierluigi Strippoli, Silvia Canaider, Francesco Noferini, Pietro D'Addabbo, Lorenza Vitale, Federica Facchin, Luca Lenzi, Raffaella Casadei, Paolo Carinci, Maria Zannotti and Flavia Frabetti
    Citation: Theoretical Biology and Medical Modelling 2005 2:40
  29. We previously demonstrated that transverse propagation of excitation (cardiac action potentials simulated with PSpice) could occur in the absence of low-resistance connections (gap – junction channels) between...

    Authors: Nicholas Sperelakis, Bijoy Kalloor and Lakshminarayanan Ramasamy
    Citation: Theoretical Biology and Medical Modelling 2005 2:36
  30. The number of founding germ cells (FGCs) in mammals is of fundamental significance to the fidelity of gene transmission between generations, but estimates from various methods vary widely. In this paper we obt...

    Authors: Chang-Jiang Zheng, E Georg Luebeck, Breck Byers and Suresh H Moolgavkar
    Citation: Theoretical Biology and Medical Modelling 2005 2:32