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  1. It is commonly accepted that embryonic segmentation of vertebrates is regulated by a segmentation clock, which is induced by the cycling genes Hes1 and Hes7. Their products form dimers that bind to the regulatory...

    Authors: Stefan Zeiser, H Volkmar Liebscher, Hendrik Tiedemann, Isabel Rubio-Aliaga, Gerhard KH Przemeck, Martin Hrabé de Angelis and Gerhard Winkler

    Citation: Theoretical Biology and Medical Modelling 2006 3:11

    Content type: Research

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  2. Two approaches to understanding growth during the cell cycle are single-cell studies, where growth during the cell cycle of a single cell is measured, and cell-culture studies, where growth during the cell cyc...

    Authors: Stephen Cooper

    Citation: Theoretical Biology and Medical Modelling 2006 3:10

    Content type: Commentary

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  3. Sepsis (bloodstream infection) is the leading cause of death in non-surgical intensive care units. It is diagnosed in 750,000 US patients per annum, and has high mortality. Current understanding of sepsis is p...

    Authors: Sergey M Zuev, Stephen F Kingsmore and Damian DG Gessler

    Citation: Theoretical Biology and Medical Modelling 2006 3:8

    Content type: Research

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  4. The hypothesis of immunosurveillance suggests that new neoplasms arise very frequently, but most are destroyed almost at their inception by an immune response. Its correctness has been debated for many years.

    Authors: Richmond T Prehn

    Citation: Theoretical Biology and Medical Modelling 2006 3:6

    Content type: Commentary

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  5. A national chlamydia screening programme is currently being rolled out in the UK and other countries. However, much of the epidemiology remains poorly understood. In this paper we present a stochastic, individ...

    Authors: Katherine ME Turner, Elisabeth J Adams, Nigel Gay, Azra C Ghani, Catherine Mercer and W John Edmunds

    Citation: Theoretical Biology and Medical Modelling 2006 3:3

    Content type: Research

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  6. Recent work has indicated an increasingly complex role for astrocytes in the central nervous system. Astrocytes are now known to exchange information with neurons at synaptic junctions and to alter the informa...

    Authors: Robert M Caudle

    Citation: Theoretical Biology and Medical Modelling 2006 3:2

    Content type: Research

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  7. There have been indications that common Angiotensin Receptor Blockers (ARBs) may be exerting anti-inflammatory actions by directly modulating the immune system. We decided to use molecular modelling to rapidly...

    Authors: Trevor G Marshall, Robert E Lee and Frances E Marshall

    Citation: Theoretical Biology and Medical Modelling 2006 3:1

    Content type: Research

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  8. Attention Deficit Hyperactivity Disorder, commonly referred to as ADHD, is a common, complex, predominately genetic but highly treatable disorder, which in its more severe form has such a profound effect on br...

    Authors: David E Comings, Thomas JH Chen, Kenneth Blum, Julie F Mengucci, Seth H Blum and Brian Meshkin

    Citation: Theoretical Biology and Medical Modelling 2005 2:50

    Content type: Review

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  9. Recent developments in Global Workspace theory suggest that human consciousness can suffer interpenetrating dysfunctions of mutual and reciprocal interaction with embedding environments which will have early o...

    Authors: Rodrick Wallace

    Citation: Theoretical Biology and Medical Modelling 2005 2:49

    Content type: Research

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  10. In previous studies on propagation of simulated action potentials (APs) in cardiac muscle using PSpice modeling, we reported that a second black-box (BB) could not be inserted into the K+ leg of the basic membran...

    Authors: Lakshminarayanan Ramasamy and Nicholas Sperelakis

    Citation: Theoretical Biology and Medical Modelling 2005 2:48

    Content type: Research

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  11. The paper of Liu, Gaido and Wolfinger on gene expression during the division cycle of HeLa cells using the data of Whitfield et al. are discussed in order to see whether their analysis is related to gene expre...

    Authors: Stephen Cooper

    Citation: Theoretical Biology and Medical Modelling 2005 2:47

    Content type: Commentary

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  12. Variation in gene expression among cells in a population is often considered as noise produced from gene transcription and post-transcription processes and experimental artifacts. Most studies on noise in gene...

    Authors: Delong Liu, Kevin W Gaido and Russ Wolfinger

    Citation: Theoretical Biology and Medical Modelling 2005 2:46

    Content type: Research

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  13. The Euglycemic Hyperinsulinemic Clamp (EHC) is the most widely used experimental procedure for the determination of insulin sensitivity, and in its usual form the patient is followed under insulinization for t...

    Authors: Umberto Picchini, Andrea De Gaetano, Simona Panunzi, Susanne Ditlevsen and Geltrude Mingrone

    Citation: Theoretical Biology and Medical Modelling 2005 2:44

    Content type: Research

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  14. Many computer studies have employed either dynamic simulation or metabolic flux analysis (MFA) to predict the behaviour of biochemical pathways. Dynamic simulation determines the time evolution of pathway prop...

    Authors: Katsuyuki Yugi, Yoichi Nakayama, Ayako Kinoshita and Masaru Tomita

    Citation: Theoretical Biology and Medical Modelling 2005 2:42

    Content type: Research

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  15. Formal description of a cell's genetic information should provide the number of DNA molecules in that cell and their complete nucleotide sequences. We pose the formal problem: can the genome sequence forming t...

    Authors: Pierluigi Strippoli, Silvia Canaider, Francesco Noferini, Pietro D'Addabbo, Lorenza Vitale, Federica Facchin, Luca Lenzi, Raffaella Casadei, Paolo Carinci, Maria Zannotti and Flavia Frabetti

    Citation: Theoretical Biology and Medical Modelling 2005 2:40

    Content type: Commentary

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  16. We previously demonstrated that transverse propagation of excitation (cardiac action potentials simulated with PSpice) could occur in the absence of low-resistance connections (gap – junction channels) between...

    Authors: Nicholas Sperelakis, Bijoy Kalloor and Lakshminarayanan Ramasamy

    Citation: Theoretical Biology and Medical Modelling 2005 2:36

    Content type: Research

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  17. Messenger RNA (mRNA) comprises three major parts: a 5'-UTR (UnTranslated Region), a coding region, and a 3'-UTR. The 3'-UTR contains signal sequences involved in polyadenylation, degradation and localization/s...

    Authors: Gonzalo E Aranda-Abreu, Ma Elena Hernández, Abraham Soto and Jorge Manzo

    Citation: Theoretical Biology and Medical Modelling 2005 2:33

    Content type: Research

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  18. The number of founding germ cells (FGCs) in mammals is of fundamental significance to the fidelity of gene transmission between generations, but estimates from various methods vary widely. In this paper we obt...

    Authors: Chang-Jiang Zheng, E Georg Luebeck, Breck Byers and Suresh H Moolgavkar

    Citation: Theoretical Biology and Medical Modelling 2005 2:32

    Content type: Research

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  19. The conception of anatomical entities as a hierarchy of infinitely graduated forms and the increase in the number of observed anatomical sub-entities and structural variables has generated a growing complexity, t...

    Authors: Fabio Grizzi and Maurizio Chiriva-Internati

    Citation: Theoretical Biology and Medical Modelling 2005 2:26

    Content type: Commentary

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  20. Embryonic stem cells (ESC) are pluripotent cells obtained from the inner cell mass (ICM) of blastocysts derived from in vitro culture associated with reproductive endocrinology therapy. Human ESCs are regarded as...

    Authors: Eric Scott Sills, Takumi Takeuchi, Noriko Tanaka, Queenie V Neri and Gianpiero D Palermo

    Citation: Theoretical Biology and Medical Modelling 2005 2:25

    Content type: Research

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  21. The authors' experience with experimentally produced femoral capital osteonecrosis in rats is reviewed: incising the periosteum at the base of the neck of the femur and cutting the ligamentum teres leads to co...

    Authors: Jacob Bejar, Eli Peled and Jochanan H Boss

    Citation: Theoretical Biology and Medical Modelling 2005 2:24

    Content type: Review

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  22. The study of the network between transcription factors and their targets is important for understanding the complex regulatory mechanisms in a cell. Unfortunately, with standard microarray experiments it is no...

    Authors: Anne-Laure Boulesteix and Korbinian Strimmer

    Citation: Theoretical Biology and Medical Modelling 2005 2:23

    Content type: Research

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  23. The need to execute a sequence of events in an orderly and timely manner is central to many biological processes, including cell cycle progression and cell differentiation. For self-perpetuating systems, such ...

    Authors: Noa Rappaport, Shay Winter and Naama Barkai

    Citation: Theoretical Biology and Medical Modelling 2005 2:22

    Content type: Research

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  24. Biology has a conceptual basis that allows one to build models and theorize across many life sciences, including medicine and medically-related disciplines. A dearth of good venues for publication has been per...

    Authors: Denys N Wheatley

    Citation: Theoretical Biology and Medical Modelling 2005 2:21

    Content type: Editorial

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  25. Transcription is the first step in cellular information processing. It is regulated by cis-acting elements such as promoters and operators in the DNA, and trans-acting elements such as transcription factors and s...

    Authors: Karthikeyan Sivaraman, Aswin Sai Narain Seshasayee, Krishnakumar Swaminathan, Geetha Muthukumaran and Gautam Pennathur

    Citation: Theoretical Biology and Medical Modelling 2005 2:20

    Content type: Research

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  26. Signaling pathways include intricate networks of reversible covalent modification cycles. Such multicyclic enzyme cascades amplify the input stimulus, cause integration of multiple signals and exhibit sensitiv...

    Authors: Vivek K Mutalik and KV Venkatesh

    Citation: Theoretical Biology and Medical Modelling 2005 2:19

    Content type: Research

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  27. Cell simulation, which aims to predict the complex and dynamic behavior of living cells, is becoming a valuable tool. In silico models of human red blood cell (RBC) metabolism have been developed by several la...

    Authors: Yoichi Nakayama, Ayako Kinoshita and Masaru Tomita

    Citation: Theoretical Biology and Medical Modelling 2005 2:18

    Content type: Research

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  28. Accommodation and breakdown of accommodation are important elements of information processing in nerve fibers, as they determine how nerve fibers react to natural slowly changing stimuli or electrical stimulat...

    Authors: Kristian Hennings, Lars Arendt-Nielsen and Ole K Andersen

    Citation: Theoretical Biology and Medical Modelling 2005 2:16

    Content type: Research

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  29. Mathematical models describing growth kinetics are very important for predicting many biological phenomena such as tumor volume, speed of disease progression, and determination of an optimal radiation and/or c...

    Authors: Mohammad Tabatabai, David Keith Williams and Zoran Bursac

    Citation: Theoretical Biology and Medical Modelling 2005 2:14

    Content type: Research

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  30. Blood viscosity is fundamentally important in clinical practice yet the apparent viscosity at very low shear rates is not well understood. Various conditions such as blunt trauma may lead to the appearance of ...

    Authors: Rovshan M Ismailov

    Citation: Theoretical Biology and Medical Modelling 2005 2:13

    Content type: Research

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