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  1. Eelgrass grants important ecological benefits including a nursery for waterfowl and fish species, shoreline stabilization, nutrient recycling and carbon sequestration. Upon the exacerbation of deleterious anth...

    Authors: Héctor Echavarría-Heras, Cecilia Leal-Ramírez, Enrique Villa-Diharce and Nohe R. Cazarez-Castro

    Citation: Theoretical Biology and Medical Modelling 2015 12:30

    Content type: Research

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  2. Cells are open complex thermodynamic systems. They can be also regarded as complex engines that execute a series of chemical reactions. Energy transformations, thermo-electro-chemical processes and transports ...

    Authors: Umberto Lucia

    Citation: Theoretical Biology and Medical Modelling 2015 12:29

    Content type: Research

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  3. The quantification of the spatial order of biological patterns or mosaics provides useful information as many properties are determined by the spatial distribution of their constituent elements. These are usua...

    Authors: Gabriela Contreras-Figueroa, Luis Hernández-Sandoval and José L. Aragón

    Citation: Theoretical Biology and Medical Modelling 2015 12:27

    Content type: Research

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  4. Gonadal sex determination (GSD) in humans is a complex biological process that takes place in early stages of embryonic development when the bipotential gonadal primordium (BGP) differentiates towards testes o...

    Authors: Osiris Ríos, Sara Frias, Alfredo Rodríguez, Susana Kofman, Horacio Merchant, Leda Torres and Luis Mendoza

    Citation: Theoretical Biology and Medical Modelling 2015 12:26

    Content type: Research

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  5. The electrocardiogram (ECG) is a diagnostic tool that records the electrical activity of the heart, and depicts it as a series of graph-like tracings, or waves. Being able to interpret these details allows dia...

    Authors: Abdelghani Ghazdali, Abdelilah Hakim, Amine Laghrib, Nezha Mamouni and Said Raghay

    Citation: Theoretical Biology and Medical Modelling 2015 12:25

    Content type: Research

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  6. Low back pain exerts a tremendous burden on individual patients and society due to its prevalence and ability to cause long-term disability. Contemporary treatment and prevention efforts are stymied by the abs...

    Authors: Chang-Jiang Zheng and James Chen

    Citation: Theoretical Biology and Medical Modelling 2015 12:24

    Content type: Research

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  7. DNA double-strand breaks (DSBs) are highly cytotoxic and mutagenic. MRE11 plays an essential role in repairing DNA by cleaving broken ends through its 3′ to 5′ exonuclease and single-stranded DNA endonuclease act...

    Authors: Imen Rekik, Zayneb Chaabene, C. Douglas Grubb, Noureddine Drira, Foued Cheour and Amine Elleuch

    Citation: Theoretical Biology and Medical Modelling 2015 12:23

    Content type: Research

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  8. Despite the unprecedented and increasing amount of data, relatively little progress has been made in molecular characterization of mechanisms underlying Parkinson’s disease. In the area of Parkinson’s research...

    Authors: Erfan Younesi, Ashutosh Malhotra, Michaela Gündel, Phil Scordis, Alpha Tom Kodamullil, Matt Page, Bernd Müller, Stephan Springstubbe, Ullrich Wüllner, Dieter Scheller and Martin Hofmann-Apitius

    Citation: Theoretical Biology and Medical Modelling 2015 12:20

    Content type: Research

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  9. The FA/BRCA pathway repairs DNA interstrand crosslinks. Mutations in this pathway cause Fanconi anemia (FA), a chromosome instability syndrome with bone marrow failure and cancer predisposition. Upon DNA damag...

    Authors: Alfredo Rodríguez, Leda Torres, Ulises Juárez, David Sosa, Eugenio Azpeitia, Benilde García-de Teresa, Edith Cortés, Rocío Ortíz, Ana M. Salazar, Patricia Ostrosky-Wegman, Luis Mendoza and Sara Frías

    Citation: Theoretical Biology and Medical Modelling 2015 12:19

    Content type: Research Article

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  10. Functional information is normally communicated using specific, context-dependent strings of symbolic characters. This is true within the human realm (texts and computer programs), and also within the biologic...

    Authors: John Sanford, Wesley Brewer, Franzine Smith and John Baumgardner

    Citation: Theoretical Biology and Medical Modelling 2015 12:18

    Content type: Research

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  11. Cachexia affects most patients with incurable cancer. We hypothesize that in metastatic cancer the mass of the tumor as well as its level of anaerobic energy metabolism play a critical role in describing its e...

    Authors: Douglas E. Friesen, Vickie E. Baracos and Jack A. Tuszynski

    Citation: Theoretical Biology and Medical Modelling 2015 12:17

    Content type: Research

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  12. In the present paper we will examine methodological frameworks to study complex genetic diseases (e.g. cancer) from the stand point of theoretical-computational biology combining both data-driven and hypothesi...

    Authors: Enrique Hernández-Lemus and J. Mario Siqueiros-García

    Citation: Theoretical Biology and Medical Modelling 2015 12:16

    Content type: Research

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  13. Protein structure prediction from amino acid sequence has been one of the most challenging aspects in computational structural biology despite significant progress in recent years showed by critical assessment...

    Authors: Bee Yin Khor, Gee Jun Tye, Theam Soon Lim and Yee Siew Choong

    Citation: Theoretical Biology and Medical Modelling 2015 12:15

    Content type: Review

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  14. A single-chain bispecific antibody (scBsAb; an engineered antibody), has promising clinical applications. Nonetheless, the effect of different interchain linkers on its activity is poorly understood.

    Authors: Chao-hui Hao, Qian-he Han, Zhong-jie Shan, Jian-ting Hu, Nan Zhang and Xue-pei Zhang

    Citation: Theoretical Biology and Medical Modelling 2015 12:14

    Content type: Research

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  15. The Editors of Theoretical Biology and Medical Modelling would like to thank all the Reviewers who have contributed to the journal in Volume 11 (2014).

    Authors: Hiroshi Nishiura, Edward Rietman and Rongling Wu

    Citation: Theoretical Biology and Medical Modelling 2015 12:4

    Content type: Reviewer acknowledgement

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  16. One of the main challenges in cancer modelling is to improve the knowledge of tumor progression in areas related to tumor growth, tumor-induced angiogenesis and targeted therapies efficacy. For this purpose, i...

    Authors: Patricio Cumsille, Aníbal Coronel, Carlos Conca, Cristóbal Quiñinao and Carlos Escudero

    Citation: Theoretical Biology and Medical Modelling 2015 12:13

    Content type: Review

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  17. Chronic lymphocytic leukemia (CLL) is an incurable malignancy of mature B-lymphocytes, characterized as being a heterogeneous disease with variable clinical manifestation and survival. Mutational statuses of r...

    Authors: María Camila Álvarez-Silva, Sally Yepes, Maria Mercedes Torres and Andrés Fernando González Barrios

    Citation: Theoretical Biology and Medical Modelling 2015 12:12

    Content type: Research

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  18. The immunotherapy using dendritic cells (DCs) against different varieties of cancer is an approach that has been previously explored which induces a specific immune response. This work presents a mathematical ...

    Authors: E. Castillo-Montiel, J. C. Chimal-Eguía, J. Ignacio Tello, G. Piñon-Zaráte, M. Herrera-Enríquez and AE. Castell-Rodríguez

    Citation: Theoretical Biology and Medical Modelling 2015 12:11

    Content type: Research

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  19. The different phases of the eukaryotic cell cycle are exceptionally well-preserved phenomena. DNA decompaction, RNA and protein synthesis (in late G1 phase) followed by DNA replication (in S phase) and lipid synt...

    Authors: Jorgelindo da Veiga Moreira, Sabine Peres, Jean-Marc Steyaert, Erwan Bigan, Loïc Paulevé, Marcel Levy Nogueira and Laurent Schwartz

    Citation: Theoretical Biology and Medical Modelling 2015 12:10

    Content type: Review

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  20. Despite a vast literature, atherosclerosis and the associated ischemia/reperfusion injuries remain today in many ways a mystery. Why do atheromatous plaques make and store a supply of cholesterol and sulfate w...

    Authors: Stephanie Seneff, Robert M. Davidson, Ann Lauritzen, Anthony Samsel and Glyn Wainwright

    Citation: Theoretical Biology and Medical Modelling 2015 12:9

    Content type: Research

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  21. N-methyl-D-Aspartate (NMDA) and its receptors (NMDAR) play a critical role in glutamatergic neurotransmission. Ethanol molecules inhibit these receptors, and if the brain is exposed to ethanol ...

    Authors: Carlos A Gutierrez and Mary M Staehle

    Citation: Theoretical Biology and Medical Modelling 2015 12:8

    Content type: Research

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  22. It has been established that stochastic effects play an important role in spatio-temporal biochemical networks. A popular method of representing such stochastic systems is the Reaction Diffusion Master Equatio...

    Authors: Atiyo Ghosh, Andre Leier and Tatiana T Marquez-Lago

    Citation: Theoretical Biology and Medical Modelling 2015 12:5

    Content type: Research

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  23. In this paper, we modify our previously developed conjoint tumor-normal cell model in order to make a distinction between tumor cells that are responsive to chemotherapy and those that may show resistance.

    Authors: Mitra Shojania Feizabadi and Tarynn M Witten

    Citation: Theoretical Biology and Medical Modelling 2015 12:3

    Content type: Research

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  24. Chlamydia is the most common sexually transmitted bacterial infection in Scotland, and is associated with potentially serious reproductive outcomes, including pelvic inflammatory disease (PID) and tubal factor...

    Authors: Katharine J Looker, Lesley A Wallace and Katherine ME Turner

    Citation: Theoretical Biology and Medical Modelling 2015 12:2

    Content type: Research

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  25. A variety of topics are reviewed in the area of mathematical and computational modeling in biology, covering the range of scales from populations of organisms to electrons in atoms. The use of maximum entropy ...

    Authors: Jack A Tuszynski, Philip Winter, Diana White, Chih-Yuan Tseng, Kamlesh K Sahu, Francesco Gentile, Ivana Spasevska, Sara Ibrahim Omar, Niloofar Nayebi, Cassandra DM Churchill, Mariusz Klobukowski and Rabab M Abou El-Magd

    Citation: Theoretical Biology and Medical Modelling 2014 11:52

    Content type: Review

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  26. Papillomavirus binding factor (PBF) or zinc finger protein 395 is a transcription factor associated to a poor prognosis in patients with osteosarcoma, an aggressive bone cancer that predominantly affects adole...

    Authors: Paola Castillo, Abraham F Cetina, Alfonso Méndez-Tenorio, Lennane Michel Espinoza-Fonseca and Blanca L Barrón

    Citation: Theoretical Biology and Medical Modelling 2014 11:51

    Content type: Research

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  27. Lyme disease imposes increasing global public health challenges. To better understand the joint effects of seasonal temperature variation and host community composition on the pathogen transmission, a stage-st...

    Authors: Yijun Lou, Jianhong Wu and Xiaotian Wu

    Citation: Theoretical Biology and Medical Modelling 2014 11:50

    Content type: Research

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  28. Estimating the required dose in radiotherapy is of crucial importance since the administrated dose should be sufficient to eradicate the tumor and at the same time should inflict minimal damage on normal cells...

    Authors: Andrew Dhawan, Kamran Kaveh, Mohammad Kohandel and Sivabal Sivaloganathan

    Citation: Theoretical Biology and Medical Modelling 2014 11:49

    Content type: Research

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  29. Considering evolution of terrestrial animals as something happening only on flat continental plains seems wrong. Many mountains have arisen and disappeared over the geologic time scale, so in all periods some ...

    Authors: Sven Kurbel

    Citation: Theoretical Biology and Medical Modelling 2014 11:47

    Content type: Review

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  30. Cardiac arrhythmias are becoming one of the major health care problem in the world, causing numerous serious disease conditions including stroke and sudden cardiac death. Furthermore, cardiac arrhythmias are i...

    Authors: Nour Eddine Alaa, Hamid Lefraich and Imane El Malki

    Citation: Theoretical Biology and Medical Modelling 2014 11:46

    Content type: Research

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  31. Children receiving Total Body Irradiation (TBI) in preparation for Hematopoietic Stem Cell Transplantation (HSCT) are at risk for Growth Hormone Deficiency (GHD), which sometimes severely compromises their Fin...

    Authors: Chiara Galletto, Antonio Gliozzi, Daniele Nucera, Nicoletta Bertorello, Eleonora Biasin, Andrea Corrias, Patrizia Chiabotto, Franca Fagioli and Caterina Guiot

    Citation: Theoretical Biology and Medical Modelling 2014 11:44

    Content type: Research

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  32. Highly successful strategies to make populations more resilient to infectious diseases, such as childhood vaccinations programs, may nonetheless lead to unpredictable outcomes due to the interplay between seas...

    Authors: Mathew P Dafilis, Federico Frascoli, Jodie McVernon, Jane M Heffernan and James M McCaw

    Citation: Theoretical Biology and Medical Modelling 2014 11:43

    Content type: Research

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  33. One of the leading causes of death and illness within the agriculture industry is through unintentionally ingesting or inhaling organophosphate pesticides. OP intoxication directly inhibits acetylcholinesteras...

    Authors: Richard R Chapleau, Peter J Robinson, John J Schlager and Jeffery M Gearhart

    Citation: Theoretical Biology and Medical Modelling 2014 11:42

    Content type: Research

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  34. In the current era of antiviral drug therapy, combining multiple drugs is a primary approach for improving antiviral effects, reducing the doses of individual drugs, relieving the side effects of strong antivi...

    Authors: Yoshiki Koizumi and Shingo Iwami

    Citation: Theoretical Biology and Medical Modelling 2014 11:41

    Content type: Review

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  35. The various cell types and their relative numbers in multicellular organisms are controlled by growth factors and related extracellular molecules which affect genetic expression pathways. However, these substa...

    Authors: Cyril J Craven

    Citation: Theoretical Biology and Medical Modelling 2014 11:40

    Content type: Research

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  36. The optimal marker for cyclosporine (CsA) monitoring in transplantation patients remains controversial. However, there is a growing interest in the use of the area under the concentration-time curve (AUC), par...

    Authors: Sarem Sarem, Jun Li, Olivier Barriere, Catherine Litalien, Yves Théorêt, Anne-Laure Lapeyraque and Fahima Nekka

    Citation: Theoretical Biology and Medical Modelling 2014 11:39

    Content type: Research

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  37. This study uses dimensional analysis to derive the general second-order differential equation that underlies numerous physical and natural phenomena described by common mathematical functions. It eschews assum...

    Authors: Gordon R Kepner

    Citation: Theoretical Biology and Medical Modelling 2014 11:38

    Content type: Research

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  38. Prostate cancer is one of the most common malignant diseases and is characterized by heterogeneity in the clinical course. To date, there are no efficient morphologic features or genomic biomarkers that can ch...

    Authors: Rudong Li, Xiao Dong, Chengcheng Ma and Lei Liu

    Citation: Theoretical Biology and Medical Modelling 2014 11:37

    Content type: Research

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  39. Lung ischemia–reperfusion injury (LIRI) may occur in the region of the affected lung after reperfusion therapy. Inhaled NO may be useful in treating acute and chronic pulmonary thromboembolism (PTE) due to the...

    Authors: Chaosheng Deng, Minxia Yang, Qichang Lin, Yuanhua Yang, Zhenguo Zhai, Kaixiong Liu, Haibo Ding, Xiaoming Cao, Zhihua Huang, Lina Zhang and Jianming Zhao

    Citation: Theoretical Biology and Medical Modelling 2014 11:36

    Content type: Research

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  40. Despite rendering serum free thyroxine (FT4) and thyrotropin (TSH) within the normal population ranges broadly defined as euthyroidism, many patients being treated for hyperthyroidism and hypothyroidism persis...

    Authors: Melvin Khee-Shing Leow and Simon L Goede

    Citation: Theoretical Biology and Medical Modelling 2014 11:35

    Content type: Research

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  41. Early detection screening of asymptomatic populations for low prevalence cancers requires a highly specific test in order to limit the cost and anxiety produced by falsely positive identifications. Most solid ...

    Authors: Matthew A Firpo, Kenneth M Boucher and Sean J Mulvihill

    Citation: Theoretical Biology and Medical Modelling 2014 11:34

    Content type: Research

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