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Page 8 of 13

  1. Proteins in any solution with a pH value that differs from their isoelectric point exert both an electric Donnan effect (DE) and colloid osmotic pressure. While the former alters the distribution of ions, the ...

    Authors: Sven Kurbel

    Citation: Theoretical Biology and Medical Modelling 2011 8:16

    Content type: Review

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  2. Mitotic chromosome motions have recently been correlated with electrostatic forces, but a lingering "molecular cell biology" paradigm persists, proposing binding and release proteins or molecular geometries fo...

    Authors: Daniel H Shain and L John Gagliardi

    Citation: Theoretical Biology and Medical Modelling 2011 8:15

    Content type: Commentary

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  3. Mathematical modeling can be employed to overcome the practical difficulty of isolating the mechanisms responsible for clinical heart failure in the setting of normal left ventricular ejection fraction (HFNEF)...

    Authors: Chuan Luo, Deepa Ramachandran, David L Ware, Tony S Ma and John W Clark Jr

    Citation: Theoretical Biology and Medical Modelling 2011 8:14

    Content type: Research

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  4. Bioinformatics can be used to predict protein function, leading to an understanding of cellular activities, and equally-weighted protein-protein interactions (PPI) are normally used to predict such protein fun...

    Authors: Khaled S Ahmed, Nahed H Saloma and Yasser M Kadah

    Citation: Theoretical Biology and Medical Modelling 2011 8:11

    Content type: Research

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  5. Avida is a computer program that performs evolution experiments with digital organisms. Previous work has used the program to study the evolutionary origin of complex features, namely logic operations, but has...

    Authors: Chase W Nelson and John C Sanford

    Citation: Theoretical Biology and Medical Modelling 2011 8:9

    Content type: Research

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  6. Biofilms are microbial communities encased in a layer of extracellular polymeric substances (EPS). The EPS matrix provides several functional purposes for the biofilm, such as protecting bacteria from environm...

    Authors: Mallory R Frederick, Christina Kuttler, Burkhard A Hense and Hermann J Eberl

    Citation: Theoretical Biology and Medical Modelling 2011 8:8

    Content type: Research

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  7. We investigated an algorithmic approach to modelling angiogenesis controlled by vascular endothelial growth factor (VEGF), the anti-angiogenic soluble VEGF receptor 1 (sVEGFR-1) and adenosine (Ado). We explore...

    Authors: Francisco Azuaje, Frédérique Léonard, Magali Rolland-Turner, Yvan Devaux and Daniel R Wagner

    Citation: Theoretical Biology and Medical Modelling 2011 8:7

    Content type: Research

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  8. Mathematical modeling of angiogenesis has been gaining momentum as a means to shed new light on the biological complexity underlying blood vessel growth. A variety of computational models have been developed, ...

    Authors: Gang Liu, Amina A Qutub, Prakash Vempati, Feilim Mac Gabhann and Aleksander S Popel

    Citation: Theoretical Biology and Medical Modelling 2011 8:6

    Content type: Research

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  9. Fatty acid biosynthesis of Mycobacterium tuberculosis was analyzed using graph theory and influential (impacting) proteins were identified. The graphs (digraphs) representing this biological network provide infor...

    Authors: Veeky Baths, Utpal Roy and Tarkeshwar Singh

    Citation: Theoretical Biology and Medical Modelling 2011 8:5

    Content type: Research

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  10. Successfully evaluating pathologists' acumen could be very useful in improving the concordance of their calls on histopathologic variables. We are proposing a new method to estimate the reviewers' acumen based...

    Authors: Wei Zhao, James M Boyett, Mehmet Kocak, David W Ellison and Yanan Wu

    Citation: Theoretical Biology and Medical Modelling 2011 8:3

    Content type: Research

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  11. While many pandemic preparedness plans have promoted disease control effort to lower and delay an epidemic peak, analytical methods for determining the required control effort and making statistical inferences...

    Authors: Ryosuke Omori and Hiroshi Nishiura

    Citation: Theoretical Biology and Medical Modelling 2011 8:2

    Content type: Research

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  12. The immune system behaves like a complex, dynamic network with interacting elements including leukocytes, cytokines, and chemokines. While the immune system is broadly distributed, leukocytes must communicate ...

    Authors: Virginia A Folcik, Gordon Broderick, Shunmugam Mohan, Brian Block, Chirantan Ekbote, John Doolittle, Marc Khoury, Luke Davis and Clay B Marsh

    Citation: Theoretical Biology and Medical Modelling 2011 8:1

    Content type: Software

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  13. We have previously suggested that the stimulatory effect of a weak immune reaction on tumor growth may be necessary for the growth of incipient tumors. In the present paper, we enlarge upon and extend that ide...

    Authors: Richmond T Prehn and Liisa M Prehn

    Citation: Theoretical Biology and Medical Modelling 2010 7:45

    Content type: Commentary

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  14. Recent experimental studies suggest that tissue stem cell pools are composed of functionally diverse clones. Metapopulation models in ecology concentrate on collections of populations and their role in stabili...

    Authors: David P Tuck and Willard Miranker

    Citation: Theoretical Biology and Medical Modelling 2010 7:44

    Content type: Research

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  15. The past thirty-five years have seen an intense search for the molecular mechanisms underlying calcium-induced calcium-release (CICR) in cardiac myocytes, with voltage clamp (VC) studies being the leading tool...

    Authors: Abhilash Krishna, Liang Sun, Miguel Valderrábano, Philip T Palade and John W Clark Jr

    Citation: Theoretical Biology and Medical Modelling 2010 7:43

    Content type: Research

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  16. Plague is a re-emerging disease and its pneumonic form is a high priority bio-terrorist threat. Epidemiologists have previously analysed historical outbreaks of pneumonic plague to better understand the dynami...

    Authors: Joseph R Egan

    Citation: Theoretical Biology and Medical Modelling 2010 7:39

    Content type: Research

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  17. Ultrasound elasticity imaging provides biomechanical and elastic properties of vascular tissue, with the potential to distinguish between tissue motion and tissue strain. To validate the ability of ultrasound ...

    Authors: Prashant Patel, Rohan Biswas, Daewoo Park, Thomas J Cichonski, Michael S Richards, Jonathan M Rubin, Sem Phan, James Hamilton and William F Weitzel

    Citation: Theoretical Biology and Medical Modelling 2010 7:36

    Content type: Research

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  18. One of the goals of computational immunology is to facilitate the study of infectious diseases. Dynamic modeling is a powerful tool to integrate empirical data from independent sources, make novel predictions,...

    Authors: Juilee Thakar, Mary Poss, Réka Albert, Gráinne H Long and Ranran Zhang

    Citation: Theoretical Biology and Medical Modelling 2010 7:35

    Content type: Commentary

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  19. The potential of using skin as an alternative path for systemically administering active drugs has attracted considerable interest, since the creation of novel drugs capable of diffusing through the skin would...

    Authors: Tatiana T Marquez-Lago, Diana M Allen and Jenifer Thewalt

    Citation: Theoretical Biology and Medical Modelling 2010 7:33

    Content type: Research

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  20. Recently, the network paradigm, an application of graph theory to biology, has proven to be a powerful approach to gaining insights into biological complexity, and has catalyzed the advancement of systems biol...

    Authors: Paolo Tieri, Andrea Grignolio, Alexey Zaikin, Michele Mishto, Daniel Remondini, Gastone C Castellani and Claudio Franceschi

    Citation: Theoretical Biology and Medical Modelling 2010 7:32

    Content type: Research

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  21. Both prophylaxis and treatment of venous thromboembolism (VTE: deep venous thrombosis (DVT) and pulmonary emboli (PE)) with anticoagulants are associated with significant risks of major and fatal hemorrhage. A...

    Authors: David K Cundiff, Paul S Agutter, P Colm Malone and John C Pezzullo

    Citation: Theoretical Biology and Medical Modelling 2010 7:31

    Content type: Review

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  22. Living things come in all shapes and sizes, from bacteria, plants, and animals to humans. Knowledge about the genetic mechanisms for biological shape has far-reaching implications for a range spectrum of scien...

    Authors: Guifang Fu, Arthur Berg, Kiranmoy Das, Jiahan LI, Runze LI and Rongling Wu

    Citation: Theoretical Biology and Medical Modelling 2010 7:28

    Content type: Research

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  23. There is still not an appealing and testable model to explain how single-celled organisms, usually following fusion of male and female gametes, proceed to grow and evolve into multi-cellular, complexly differe...

    Authors: Edward C Elson

    Citation: Theoretical Biology and Medical Modelling 2010 7:26

    Content type: Research

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  24. Analyze an approach to distributing transperineal prostate biopsy cores that yields data on the volume of a tumor that might be present when the biopsy is negative, and also increases detection efficiency.

    Authors: Gordon R Kepner and Jeremy V Kepner

    Citation: Theoretical Biology and Medical Modelling 2010 7:23

    Content type: Research

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  25. Alzheimer's disease, known to be associated with the gradual loss of memory, is characterized by low concentration of acetylcholine in the hippocampus and cortex part of the brain. Inhibition of acetylcholines...

    Authors: Zaheer Ul-Haq, Waqasuddin Khan, Saima Kalsoom and Farzana L Ansari

    Citation: Theoretical Biology and Medical Modelling 2010 7:22

    Content type: Research

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  26. In this paper we consider two approaches to examining the complex dynamics of conjoint aging-cancer cellular systems undergoing chemotherapeutic intervention. In particular, we focus on the effect of cells gro...

    Authors: Mitra S Feizabadi and Tarynn M Witten

    Citation: Theoretical Biology and Medical Modelling 2010 7:21

    Content type: Research

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  27. According to the hypothesis explored in this paper, native aggregation is genetically controlled (programmed) reversible aggregation that occurs when interacting proteins form new temporary structures through ...

    Authors: Vladimir V Matveev

    Citation: Theoretical Biology and Medical Modelling 2010 7:19

    Content type: Review

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  28. ChIP-Seq is a powerful tool for identifying the interaction between genomic regulators and their bound DNAs, especially for locating transcription factor binding sites. However, high cost and high rate of fals...

    Authors: Song Wu, Jianmin Wang, Wei Zhao, Stanley Pounds and Cheng Cheng

    Citation: Theoretical Biology and Medical Modelling 2010 7:18

    Content type: Research

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  29. Humans are routinely and concurrently exposed to multiple toxic chemicals, including various metals and organics, often at levels that can cause adverse and potentially synergistic effects. However, toxicokine...

    Authors: Alan F Sasso, Sastry S Isukapalli and Panos G Georgopoulos

    Citation: Theoretical Biology and Medical Modelling 2010 7:17

    Content type: Research

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  30. Glucocorticoids (GC) represent the core treatment modality for many inflammatory diseases. Its mode of action is difficult to grasp, not least because it includes direct modulation of many components of the ex...

    Authors: Uwe Klinge, Nicolette Farman and Anette Fiebeler

    Citation: Theoretical Biology and Medical Modelling 2010 7:16

    Content type: Research

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  31. Although the prognosis for Lupus Nephritis (LN) has dramatically improved with aggressive immunosuppressive therapies, these drugs carry significant side effects. To improve the effectiveness of these drugs, b...

    Authors: Paula Budu-Grajdeanu, Richard C Schugart, Avner Friedman, Daniel J Birmingham and Brad H Rovin

    Citation: Theoretical Biology and Medical Modelling 2010 7:14

    Content type: Research

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  32. In many areas of medical research, a bivariate analysis is desirable because it simultaneously tests two response variables that are of equal interest and importance in two populations. Several parametric and ...

    Authors: Hamed Tabesh, S MT Ayatollahi and Mina Towhidi

    Citation: Theoretical Biology and Medical Modelling 2010 7:13

    Content type: Research

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