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  1. Review

    Perspective on the dynamics of cancer

    The genetic diversity of cancer and the dynamic interactions between heterogeneous tumor cells, the stroma and immune cells present daunting challenges to the development of effective cancer therapies. Althoug...

    Youcef Derbal

    Theoretical Biology and Medical Modelling 2017 14:18

    Published on: 3 October 2017

  2. Research

    Forecasting infectious disease emergence subject to seasonal forcing

    Despite high vaccination coverage, many childhood infections pose a growing threat to human populations. Accurate disease forecasting would be of tremendous value to public health. Forecasting disease emergenc...

    Paige B. Miller, Eamon B. O’Dea, Pejman Rohani and John M. Drake

    Theoretical Biology and Medical Modelling 2017 14:17

    Published on: 6 September 2017

  3. Review

    Test-and-treat approach to HIV/AIDS: a primer for mathematical modeling

    The public benefit of test-and-treat has induced a need to justify goodness for the public, and mathematical modeling studies have played a key role in designing and evaluating the test-and-treat strategy for ...

    Kyeongah Nah, Hiroshi Nishiura, Naho Tsuchiya, Xiaodan Sun, Yusuke Asai and Akifumi Imamura

    Theoretical Biology and Medical Modelling 2017 14:16

    Published on: 5 September 2017

  4. Research

    Transmission dynamics of cholera in Yemen, 2017: a real time forecasting

    A large epidemic of cholera, caused by Vibrio cholerae, serotype Ogawa, has been ongoing in Yemen, 2017. To improve the situation awareness, the present study aimed to forecast the cholera epidemic, explicitly ad...

    Hiroshi Nishiura, Shinya Tsuzuki, Baoyin Yuan, Takayuki Yamaguchi and Yusuke Asai

    Theoretical Biology and Medical Modelling 2017 14:14

    Published on: 26 July 2017

  5. Research

    Modelling infectious diseases with relapse: a case study of HSV-2

    Herpes Simplex Virus Type 2 (HSV-2) is one of the most common sexually transmitted diseases. Although there is still no licensed vaccine for HSV-2, a theoretical investigation of the potential effects of a vac...

    Jinliang Wang, Xiaoqing Yu, Heidi L. Tessmer, Toshikazu Kuniya and Ryosuke Omori

    Theoretical Biology and Medical Modelling 2017 14:13

    Published on: 17 July 2017

  6. Research

    Markov modeling in hepatitis B screening and linkage to care

    With up to 240 million people chronically infected with hepatitis B worldwide, including an estimated 2 million in the United States, widespread screening is needed to link the infected to care and decrease th...

    Martin A. Sehr, Kartik D. Joshi, John M. Fontanesi, Robert J. Wong, Robert R. Bitmead and Robert G. Gish

    Theoretical Biology and Medical Modelling 2017 14:11

    Published on: 18 May 2017

  7. Research

    A highly pathogenic simian/human immunodeficiency virus effectively produces infectious virions compared with a less pathogenic virus in cell culture

    The host range of human immunodeficiency virus (HIV) is quite narrow. Therefore, analyzing HIV-1 pathogenesis in vivo has been limited owing to lack of appropriate animal model systems. To overcome this, chime...

    Shoya Iwanami, Yusuke Kakizoe, Satoru Morita, Tomoyuki Miura, Shinji Nakaoka and Shingo Iwami

    Theoretical Biology and Medical Modelling 2017 14:9

    Published on: 21 April 2017

  8. Research

    Establishment of a new initial dose plan for vancomycin using the generalized linear mixed model

    When administering vancomycin hydrochloride (VCM), the initial dose is adjusted to ensure that the steady-state trough value (Css-trough) remains within the effective concentration range. However, the Css-trou...

    Yasuyuki Kourogi, Kenji Ogata, Norito Takamura, Jin Tokunaga, Nao Setoguchi, Mitsuhiro Kai, Emi Tanaka and Susumu Chiyotanda

    Theoretical Biology and Medical Modelling 2017 14:8

    Published on: 8 April 2017

  9. Research

    High resolution hemodynamic profiling of murine arteriovenous fistula using magnetic resonance imaging and computational fluid dynamics

    Arteriovenous fistula (AVF) maturation failure remains a major cause of morbidity and mortality in hemodialysis patients. The two major etiologies of AVF maturation failure are early neointimal hyperplasia dev...

    Daniel Pike, Yan-Ting Shiu, Maheshika Somarathna, Lingling Guo, Tatyana Isayeva, John Totenhagen and Timmy Lee

    Theoretical Biology and Medical Modelling 2017 14:5

    Published on: 20 March 2017

  10. Research

    The role of mobility and health disparities on the transmission dynamics of Tuberculosis

    The transmission dynamics of Tuberculosis (TB) involve complex epidemiological and socio-economical interactions between individuals living in highly distinct regional conditions. The level of exogenous reinfe...

    Victor Moreno, Baltazar Espinoza, Kamal Barley, Marlio Paredes, Derdei Bichara, Anuj Mubayi and Carlos Castillo-Chavez

    Theoretical Biology and Medical Modelling 2017 14:3

    Published on: 28 January 2017

  11. Research

    Thermodynamic considerations in renal separation processes

    Urine production in the kidney is generally thought to be an energy-intensive process requiring large amounts of metabolic activity to power active transport mechanisms. This study uses a thermodynamic analysi...

    Robert H. Louw, David M. Rubin, David Glasser, Robyn F. R. Letts and Diane Hildebrandt

    Theoretical Biology and Medical Modelling 2017 14:2

    Published on: 26 January 2017

  12. Research

    Personalized life expectancy and treatment benefit index of antiretroviral therapy

    The progression of Human Immunodeficiency Virus (HIV) within host includes typical stages and the Antiretroviral Therapy (ART) is shown to be effective in slowing down this progression. There are great challen...

    Yanni Xiao, Xiaodan Sun, Sanyi Tang, Yicang Zhou, Zhihang Peng, Jianhong Wu and Ning Wang

    Theoretical Biology and Medical Modelling 2017 14:1

    Published on: 18 January 2017

  13. Research

    Estimating transmission probability in schools for the 2009 H1N1 influenza pandemic in Italy

    Epidemic models are being extensively used to understand the main pathways of spread of infectious diseases, and thus to assess control methods. Schools are well known to represent hot spots for epidemic sprea...

    Valentina Clamer, Ilaria Dorigatti, Laura Fumanelli, Caterina Rizzo and Andrea Pugliese

    Theoretical Biology and Medical Modelling 2016 13:19

    Published on: 12 October 2016

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