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  1. Develop and validate particular, concrete, and abstract yet plausible in silico mechanistic explanations for large intra- and interindividual variability observed for eleven bioequivalence study participants. ...

    Authors: Sean HJ Kim, Andre J Jackson, Rim Hur and C Anthony Hunt
    Citation: Theoretical Biology and Medical Modelling 2012 9:39
  2. We investigated the relationship of End-to-end distance between VH and VL with different peptide linkers and the activity of single-chain antibodies by computer-aided simulation. First, we developed (G4S)n (where...

    Authors: Jianhua Zhang, Shanhong Liu, Zhigang Shang, Li Shi and Jun Yun
    Citation: Theoretical Biology and Medical Modelling 2012 9:38
  3. Authors: Piernicola Pedicini, Rocchina Caivano, Barbara A Jereczek-Fossa, Lidia Strigari, Barbara Vischioni, Daniela Alterio, Marta Cremonesi, Francesca Botta, Antonio Nappi, Giuseppina Improta, Giovanni Storto, Alba Fiorentino, Marcello Benassi, Roberto Orecchia and Vincenzo Fusco
    Citation: Theoretical Biology and Medical Modelling 2012 9:37

    The original article was published in Theoretical Biology and Medical Modelling 2012 9:23

  4. The invasion-metastasis cascade of cancer involves a process of parallel progression. A biological interface (module) in which cells is linked with ECM (extracellular matrix) by CAMs (cell adhesion molecules) ...

    Authors: Feng-Chou Tsai, Mei-Chuan Wang, Jeng-Fan Lo, Chih-Ming Chou and Yi-Lu Lin
    Citation: Theoretical Biology and Medical Modelling 2012 9:36
  5. Discovering new biomarkers has a great role in improving early diagnosis of Hepatocellular carcinoma (HCC). The experimental determination of biomarkers needs a lot of time and money. This motivates this work ...

    Authors: Nagwan M Abdel Samee, Nahed H Solouma and Yasser M Kadah
    Citation: Theoretical Biology and Medical Modelling 2012 9:34
  6. Proteolytic degradation of the extracellular matrix (ECM) is a key event in tumour metastasis and invasion. Matrix metalloproteinases (MMPs) are a family of endopeptidases that degrade most of the components o...

    Authors: Takashi Saitou, Keiko Itano, Daisuke Hoshino, Naohiko Koshikawa, Motoharu Seiki, Kazuhisa Ichikawa and Takashi Suzuki
    Citation: Theoretical Biology and Medical Modelling 2012 9:33
  7. The human granulocyte colony-stimulating factor (G-CSF) is routinely applied to support recovery of granulopoiesis during the course of cytotoxic chemotherapies. However, optimal use of the drug is largely unk...

    Authors: Markus Scholz, Sibylle Schirm, Marcus Wetzler, Christoph Engel and Markus Loeffler
    Citation: Theoretical Biology and Medical Modelling 2012 9:32
  8. The role of the immune system in tumor progression has been a subject for discussion for many decades. Numerous studies suggest that a low immune response might be beneficial, if not necessary, for tumor growt...

    Authors: Heiko Enderling, Lynn Hlatky and Philip Hahnfeldt
    Citation: Theoretical Biology and Medical Modelling 2012 9:31
  9. Human papillomavirus (HPV) types 16 and 18 are the high-risk, sexually transmitted infectious causes of most cervical intraepithelial neoplasias (CIN) or cancers. While efficacious vaccines to reduce the sexua...

    Authors: Misaki Wayengera
    Citation: Theoretical Biology and Medical Modelling 2012 9:30
  10. This study investigated two different mathematical models for the kinetics of anaerobic power. Model 1 assumes that the work power is linear with the work rate, while Model 2 assumes a linear relationship betw...

    Authors: John F Moxnes, Kjell Hausken and Øyvind Sandbakk
    Citation: Theoretical Biology and Medical Modelling 2012 9:29
  11. While many branches of natural science have embraced group theory reaping enormous advantages for their respective fields, clinical medicine lacks to date such applications. Here we intend to explain a prototy...

    Authors: Jitsuki Sawamura, Shigeru Morishita and Jun Ishigooka
    Citation: Theoretical Biology and Medical Modelling 2012 9:28
  12. Super-macromolecular complexes play many important roles in eukaryotic cells. Classical structural biological studies focus on their complicated molecular structures, physical interactions and biochemical modi...

    Authors: Yue Zhao and Qimin Zhan
    Citation: Theoretical Biology and Medical Modelling 2012 9:26
  13. To estimate the effects of heterogeneity on tumour cell sensitivity to radiotherapy combined with radiosensitizing agents attributable to differences in expression levels of Epidermal Growth Factor Receptor (EGFr

    Authors: Piernicola Pedicini, Rocchina Caivano, Barbara Alicia Jereczek-Fossa, Lidia Strigari, Barbara Vischioni, Daniela Alterio, Marta Cremonesi, Francesca Botta, Antonio Nappi, Giuseppina Improta, Giovanni Storto, Marcello Benassi and Roberto Orecchia
    Citation: Theoretical Biology and Medical Modelling 2012 9:23

    The Erratum to this article has been published in Theoretical Biology and Medical Modelling 2012 9:37

  14. Medical records accumulate data concerning patient health and the natural history of disease progression. However, methods to mine information systematically in a form other than an electronic health record ar...

    Authors: Eric Aslakson, Smadar Szekely, Suzanne D Vernon, Lucinda Bateman, Jan Baumbach and Yaki Setty
    Citation: Theoretical Biology and Medical Modelling 2012 9:22
  15. Human milk samples contain microvesicles similar to the retroviruses. These microvesicles contain mRNA transcripts and possess reverse transcriptase activity. They contain about 14,000 transcripts representing...

    Authors: M Kemal Irmak, Yesim Oztas and Emin Oztas
    Citation: Theoretical Biology and Medical Modelling 2012 9:20
  16. Computational identification of transcription factor binding sites (TFBSs) is a rapid, cost-efficient way to locate unknown regulatory elements. With increased potential for high-throughput genome sequencing, ...

    Authors: Mingfeng Tan, Dong Yu, Yuan Jin, Lei Dou, Beiping LI, Yuelan Wang, Junjie Yue and Long Liang
    Citation: Theoretical Biology and Medical Modelling 2012 9:19
  17. Transplantation is often the only way to treat a number of diseases leading to organ failure. To overcome rejection towards the transplanted organ (graft), immunosuppression therapies are used, which have cons...

    Authors: AndreaDe Gaetano, Alice Matone, Annamaria Agnes, Pasquale Palumbo, Francesco Ria and Sabina Magalini
    Citation: Theoretical Biology and Medical Modelling 2012 9:18
  18. Several formulations have been proposed in order to model human growth from birth to maturity. They are usually based on “ad hoc” heuristic assumptions. In the present contribution we adopt, as an alternative,...

    Authors: Antonio S Gliozzi, Caterina Guiot, Pier Paolo Delsanto and Dan A Iordache
    Citation: Theoretical Biology and Medical Modelling 2012 9:17
  19. Consensus exists that several bariatric surgery procedures produce a rapid improvement of glucose homeostasis in obese diabetic patients, improvement apparently uncorrelated with the degree of eventual weight ...

    Authors: Puntip Toghaw, Alice Matone, Yongwimon Lenbury and Andrea De GAETANO
    Citation: Theoretical Biology and Medical Modelling 2012 9:16
  20. An allometric relationship between different electrocardiogram (ECG) parameters and infarcted ventricular mass was assessed in a myocardial infarction (MI) model in New Zealand rabbits.

    Authors: Maria P Bonomini, Pedro D Arini, Germán E Gonzalez, Bruno Buchholz and Max E Valentinuzzi
    Citation: Theoretical Biology and Medical Modelling 2012 9:15
  21. This article proposes a model of bone remodeling that encompasses mechanical and electrical stimuli. The remodeling formulation proposed by Weinans and collaborators was used as the basis of this research, wit...

    Authors: Diego A Garzón-Alvarado, Angélica M Ramírez-Martínez and Carmen Alicia Cardozo de Martínez
    Citation: Theoretical Biology and Medical Modelling 2012 9:14
  22. Lordosis is the bending of the lumbar spine that gives the vertebral column of humans its characteristic ventrally convex curvature. Infants develop lordosis around the time when they acquire bipedal locomotio...

    Authors: Heiko Wagner, Anne Liebetrau, David Schinowski, Thomas Wulf and Marc HE de Lussanet
    Citation: Theoretical Biology and Medical Modelling 2012 9:13
  23. An accepted hypothesis states that coronary atherosclerosis (CA) is initiated by endothelial dysfunction due to inflammation and high levels of LDL-C, followed by deposition of lipids and macrophages from the ...

    Authors: Vladimir M Subbotin
    Citation: Theoretical Biology and Medical Modelling 2012 9:11
  24. Recent studies have implicated viral characteristics in accounting for the variation in the HIV set-point viral load (spVL) observed among individuals. These studies have suggested that the spVL might be a her...

    Authors: Diego F Cuadros and Gisela García-Ramos
    Citation: Theoretical Biology and Medical Modelling 2012 9:9
  25. The fields of molecular biology and computer science have cooperated over recent years to create a synergy between the cybernetic and biosemiotic relationship found in cellular genomics to that of information ...

    Authors: David J D'Onofrio, David L Abel and Donald E Johnson
    Citation: Theoretical Biology and Medical Modelling 2012 9:8
  26. In clinical practice, the common strategy for immunotherapy of nasopharyngeal carcinoma (NPC) is to infuse cytotoxic T-lymphocyte (CTL) lines several times by intravenous injection, but it is difficult by labo...

    Authors: Wang Shengjun, Guo Yunbo, Song Liyan, Li Jinming and Deng Qinkai
    Citation: Theoretical Biology and Medical Modelling 2012 9:6
  27. The study of typical morphological variations using quantitative, morphometric descriptors has always interested biologists in general. However, unusual examples of form, such as abnormalities are often encoun...

    Authors: Peter Claes, Katleen Daniels, Mark Walters, John Clement, Dirk Vandermeulen and Paul Suetens
    Citation: Theoretical Biology and Medical Modelling 2012 9:5
  28. In this paper, a new mathematical model is developed to represent the interaction between healthy and cancer cells in the human body, focusing on the role of environmental factors and quality of life in the pr...

    Authors: Ali Ghaffari and Mostafa Khazaee
    Citation: Theoretical Biology and Medical Modelling 2012 9:4
  29. The aim of this study is to assess the protective effects of Ginkgo biloba's (GB) extract against chemotherapeutic-induced reproductive toxicity using a data mining tool, namely Neural Network Clustering (NNC) on...

    Authors: Amr Amin, Doaa Mahmoud-Ghoneim, Muhammed I Syam and Sayel Daoud
    Citation: Theoretical Biology and Medical Modelling 2012 9:1
  30. Solid tumors are heterogeneous in composition. Cancer stem cells (CSCs) are believed to drive tumor progression, but the relative frequencies of CSCs versus non-stem cancer cells span wide ranges even within t...

    Authors: Charles I Morton, Lynn Hlatky, Philip Hahnfeldt and Heiko Enderling
    Citation: Theoretical Biology and Medical Modelling 2011 8:48
  31. With the development of experimental techniques and bioinformatics, the quantity of data available from protein-protein interactions (PPIs) is increasing exponentially. Functional modules can be identified fro...

    Authors: Xia Wang, Junjie Yue, Xianwen Ren, Yuelan Wang, Mingfeng Tan, Beiping LI and Long Liang
    Citation: Theoretical Biology and Medical Modelling 2011 8:47
  32. Multiscale agent-based modeling (MABM) has been widely used to simulate Glioblastoma Multiforme (GBM) and its progression. At the intracellular level, the MABM approach employs a system of ordinary differential e...

    Authors: Le Zhang, Beini Jiang, Yukun Wu, Costas Strouthos, Phillip Zhe Sun, Jing Su and Xiaobo Zhou
    Citation: Theoretical Biology and Medical Modelling 2011 8:46
  33. Elucidating the effects of drugs on solid tumours is a highly challenging multi-level problem, since this involves many complexities associated with transport and cellular response, which in turn is characteri...

    Authors: Cong Liu, J Krishnan and Xiao Yun Xu
    Citation: Theoretical Biology and Medical Modelling 2011 8:45
  34. Epidemiological studies have shown that imposing travel restrictions to prevent or delay an influenza pandemic may not be feasible. To delay an epidemic substantially, an extremely high proportion of trips (~9...

    Authors: Elson HY Lam, Benjamin J Cowling, Alex R Cook, Jessica YT Wong, Max SY Lau and Hiroshi Nishiura
    Citation: Theoretical Biology and Medical Modelling 2011 8:44
  35. Competing risks, which are particularly encountered in medical studies, are an important topic of concern, and appropriate analyses must be used for these data. One feature of competing risks is the cumulative...

    Authors: Zahra Shayan, SeyyedMohammadTaghi Ayatollahi and Najaf Zare
    Citation: Theoretical Biology and Medical Modelling 2011 8:43
  36. Expanded polytetrafluoroethylene (ePTFE) vascular grafts frequently develop occlusive neointimal hyperplasia as a result of myofibroblast over-growth, leading to graft failure. ePTFE exhibits higher ultrasound...

    Authors: Mark R Brinton, Russell J Stewart, Alfred K Cheung, Douglas A Christensen and Yan-Ting E Shiu
    Citation: Theoretical Biology and Medical Modelling 2011 8:42
  37. Even though many functions of protein-x from the Hepatitis B virus (HBV) have been revealed, the nature of protein-x is yet unknown. This protein is well-known for its transactivation activity through interact...

    Authors: Ashraf Mohamadkhani, Parisa Shahnazari, Zarrin Minuchehr, Armin Madadkar-Sobhani, Mahmoud Jeddi Tehrani, Ferdous Rastgar Jazii and Hossein Poustchi
    Citation: Theoretical Biology and Medical Modelling 2011 8:41
  38. Thousands of children experience cardiac arrest events every year in pediatric intensive care units. Most of these children die. Cardiac arrest prediction tools are used as part of medical emergency team evalu...

    Authors: Curtis E Kennedy and James P Turley
    Citation: Theoretical Biology and Medical Modelling 2011 8:40
  39. Increasing the predictability and reducing the rate of side effects of oral anticoagulant treatment (OAT) requires further clarification of the cause of about 50% of the interindividual variability of OAT resp...

    Authors: Alexandru D Corlan and John Ross
    Citation: Theoretical Biology and Medical Modelling 2011 8:37