%PDF-1.3
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Metastatic tumors,Treatment,Chemotherapy,Immunotherapy
Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
application/pdf
10.1186/s12976-021-00142-1
Theoretical Biology and Medical Modelling
Theoretical Biology and Medical Modelling, 2021, doi:10.1186/s12976-021-00142-1
Metastatic tumors
Treatment
Chemotherapy
Immunotherapy
How mathematical modeling could contribute to the quantification of metastatic tumor burden under therapy: insights in immunotherapeutic treatment of non-small cell lung cancer
Pirmin Schlicke
Christina Kuttler
Christian Schumann
2021-06-02T11:05:32+02:00
2021-06-02T11:05:32+02:00
2021-05-21T10:12:24+08:00
LaTeX with hyperref package
uuid:0ec30f6d-37fa-490d-b400-3a04b17a7060
uuid:945cb249-11cb-4d42-99d5-ec2fc75394a8
default
1
converted
uuid:0ec30f6d-37fa-490d-b400-3a04b17a7060
converted to PDF/A-2b
pdfToolbox
2021-05-27T17:31:35+08:00
2
B
Pirmin Schlicke
http://orcid.org/0000-0001-9619-728X
Springer Nature ORCID Schema
http://springernature.com/ns/xmpExtensions/2.0/
sn
authorInfo
Bag AuthorInformation
external
Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.
editorInfo
Bag EditorInformation
external
Editor information: contains the name of each editor and his/her ORCID identifier.
seriesEditorInfo
Bag SeriesEditorInformation
external
Series editor information: contains the name of each series editor and his/her ORCID identifier.
AuthorInformation
http://springernature.com/ns/xmpExtensions/2.0/authorInfo/
author
Specifies the types of author information: name and ORCID of an author.
name
Text
Gives the name of an author.
orcid
URI
Gives the ORCID of an author.
EditorInformation
http://springernature.com/ns/xmpExtensions/2.0/editorInfo/
editor
Specifies the types of editor information: name and ORCID of an editor.
name
Text
Gives the name of an editor.
orcid
URI
Gives the ORCID of an editor.
SeriesEditorInformation
http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/
seriesEditor
Specifies the types of series editor information: name and ORCID of a series editor.
name
Text
Gives the name of a series editor.
orcid
URI
Gives the ORCID of a series editor.
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
internal
A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.
DerivedFrom
ResourceRef
Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.
http://ns.adobe.com/xap/1.0/sType/Part#
stPart
Part
http://ns.adobe.com/xap/1.0/t/pg/
xmpTPg
XMP Paged-Text
internal
A structure containing the characteristics of a font used in a document
Fonts
Bag Font
internal
XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).
PlateNames
Seq Text
A structure containing the characteristics of a font used in a document.
http://ns.adobe.com/xap/1.0/sType/Font#
stFnt
Font
http://ns.adobe.com/pdfx/1.3/
pdfx
Adobe Document Info PDF eXtension Schema
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
endstream
endobj
3 0 obj
<>
endobj
8 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[377.55 111.09 538.95 119.949]>>
endobj
10 0 obj
<>/BBox[0 0 150.267 8.274]/Length 15>>stream
HR(T0 u
endstream
endobj
11 0 obj
<>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI]/Font<>>>/Annots[26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R]/CropBox[0 0 595 791]/Parent 50 0 R/Rotate 0/MediaBox[0 0 595 791]/TrimBox[0 0 595 791]>>
endobj
4 0 obj
<>
endobj
115 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[317.799 102.216 475.383 111.246]>>
endobj
26 0 obj
<>/Rect[253.161 632.856 260.058 641.283]>>
endobj
5 0 obj
<>
endobj
182 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[448.911 75.216 537.996 83.949]>>
endobj
27 0 obj
<>/Rect[181.656 596.991 188.553 605.418]>>
endobj
6 0 obj
<>
endobj
249 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[317.799 66.216 523.767 74.949]>>
endobj
251 0 obj
<>
endobj
28 0 obj
<>/Rect[199.881 573.087 206.778 581.505]>>
endobj
7 0 obj
<>
endobj
297 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[317.799 57.216 361.191 66.246]>>
endobj
29 0 obj
<>/Rect[210.69 573.087 217.587 581.505]>>
endobj
254 0 obj
<>
endobj
21 0 obj
<>
endobj
30 0 obj
<>/Rect[184.905 537.213 191.802 545.64]>>
endobj
255 0 obj
<>
endobj
22 0 obj
<>
endobj
31 0 obj
<>/Rect[195.714 537.213 207.516 545.64]>>
endobj
256 0 obj
<>
endobj
304 0 obj
<>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI]/Font<>/Properties<>>>/Annots[314 0 R 315 0 R 316 0 R 317 0 R 318 0 R 319 0 R 320 0 R 321 0 R 322 0 R 323 0 R]/CropBox[0 0 595 791]/Parent 324 0 R/Rotate 0/MediaBox[0 0 595 791]/TrimBox[0 0 595 791]>>
endobj
32 0 obj
<>/Rect[81.225 513.309 93.027 521.727]>>
endobj
257 0 obj
<>
endobj
314 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[130.653 682.203 266.952 690.927]>>
endobj
33 0 obj
<>/Rect[273.798 441.534 285.6 449.952]>>
endobj
258 0 obj
<>
endobj
315 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[70.902 673.077 267.339 682.233]>>
endobj
305 0 obj
<>
endobj
34 0 obj
<>/Rect[200.88 345.891 212.682 354.309]>>
endobj
259 0 obj
<>
endobj
316 0 obj
<>/C[0 1 1]/Subtype/Link/F 4/Type/Annot/H/I/Border[0 0 0]/AP<>/Rect[206.478 646.203 285.321 654.927]>>
endobj
252 0 obj
<>stream
Hd{PS%9Q^.}j݊hj)Ed 6!
%:JA# 5( P\pv,jgM39=P@( EEnߵ%#Kqz0W0Wn5jg+8"1Ѣ08a!\LX<<YѦKxIvU&..NQS2ˌ&!l._o(rMjUlV+6vj9363Vt&&1VV֩
u@xlJzVnJ])S )`H[V (@& $!LB,
1CI
Q|9=ůxpNiDΒ$|rhp;ty䐃4P(x t-~z٥9١EퟹYq -yWNKՁ4Y<ںo1^qsnOCZ*۸?<ў54&sou*J aCytS/Oؘ%c[|"q_zVd7b|iėR 4BD5eQvd}[."sGZQCڙ
&{^ݣmǖUmN37a@xg
x*G9#~@;MS?yf͞hȆU7O!>] kZO>6&NcYn`mSYOs*/
) :ގJ{kǐ[+I 8}>KkF N@1l.~Whyɿ*gYwGHlAiN`K^?!d9+&