Figure 13

LH released during constant exposure (Panel A) and to 5 minute pulses every 15 minutes (Panel B) to 5 nM GnRH. Open circles indicate the model with no desensiti-zation of calcium channels in outer membrane (v₁ = 0 and v₂ = 0); solid circles indicate the model with calcium channel desensitization but with no internalization of receptors (k₁₁ = 0); open squares indicate the full model.