Figure 2

Regulatory functions in compartment CE. Regulatory functions describing the effect of Filgrastim, Pegfilgrastim, EPO and combinations of it on amplification rate and transition time in the compartment CE. While amplification is assumed to be unaffected by G-CSF, the transition time is delayed under G-CSF stimulation. A: Delay factor of transition time - dependence on endogenous G-CSF/Filgrastim concentration. We mark the values achieved at steady-state (green) and at maximum after a single s.c. application of 480 μ g (black). B: Delay factor of transition time - dependence on Pegfilgrastim concentration. Values achieved at maximum after a single s.c. application of 6000 μ g (black) and steady state (green) are marked. C: Amplification in CE - dependence on internalised EPO. No G-CSF effects are assumed here. D: Transition times in CE - dependence on internalised EPO and G-CSF concentration. We present the raw regulatory functions without considering G-CSF effects (dotted) and maximal deviations after either Filgrastim application of 480 μ g (solid) or Pegfilgrastim application of 6000 μ g (grey). Note that the regulatory functions presented in A and B are superimposed (Equation 16) under Pegfilgrastim or combined Pegfilgrastim/Filgrastim applications.