Table 4 Estimated and determined parameter values for lean (BMI ≤ 25) and overweight or obese (BMI > 25) subjects.
From: A mathematical model of the euglycemic hyperinsulinemic clamp
Lean (n = 7) | Overweight or Obese (n = 8) | p | |
|---|---|---|---|
Estimated Parameters | |||
Gb [mM] | 3.67 [2.80, 4.36] | 5.11 [4.52, 5.97] | 0.001 |
Ib [pM] | 17.91 [8.59, 63.41] | 121.05 [61.55, 256.41] | 0.002 |
KxgI [min-1/pM] | 9.94 · [7.1, 21.2] · 10-6 | 6.34 · [0, 13.3] · 10-6 | 0.132 |
Kxi [min-1] | 0.039 [0.022, 0.057] | 0.029 [0.021, 0.045] | 0.203 |
Tghmax [mmol/min/kgBW] | 0.069 [0.05, 0.12] | 0.128 [0.026, 0.274] | 0.105 |
Vg [L/kgBW] | 0.49 [0.33, 0.90] | 0.47 [0.25, 0.67] | 0.643 |
Vi [L/kgBW] | 0.4 [0.36, 0.78] | 0.39 [0.21, 0.65] | 0.487 |
α [#] | 0.017 [0.015, 0.082] | 0.024 [0.008, 0.048] | 0.908 |
τg [min] | 3.00 [1.00, 11.50] | 5.14 [0.50, 9.00] | 0.917 |
λ [mM-1pM-1] | 8.9 [1.2, 21.3] · 10-3 | 3.1 [0.2, 4] · 10-3 | 0.037 |
Determined Parameters | |||
Tghb [mmol/min/kgBW] | 0.042 [0.028, 0.052] | 0.019 [0.009, 0.117] | 0.36 |
Txg [mM / min] | 0.085 [0.057, 0.126] | 0.046 [0.012, 0.397] | 0.203 |
TiG [pM/min/mM] | 0.096 [0.031, 0.29] | 0.267 [0.128, 0.668] | 0.011 |
ρ [#] | 115.4 [24.3, 136.2] | 83.6 [42.1, 267.7] | 0.908 |