Figure 14
From: Computer simulation analysis of normal and abnormal development of the mammalian diaphragm
Simulation IV – edge-growth with chest-wall trophism and tropism. Mitotically-active non-edge cells which fall under the "trophic" effect of the body wall now actively migrate towards the body wall (tropism). Each hemi-diaphragm now adopts a more curvilinear shape. There is a more robust anterior extension of the muscular diaphragm, but the CDH defect fails to enlarge appropriately, and diaphragm tissue anterior to the CDH is somewhat hypoplastic.