Figure 3From: Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) modelsMean of the predicted plasma concentration time curves (line) of MDZ and 1OH-MDZ following an intravenous administration of 0.15 mg/kg as compared to the mean (n = 6) of the experimental data. Experimental data was taken from Heizmann et al. [11].Back to article page