Figure 6

Changes at the molecular level for Cell No 48 with an increasing extrinsic EGF concentration (rule A). Four simulation runs are depicted where (from left to right) the EGF concentration increases from 2.65 × 1.0 to 2.65 × 31.1, 2.65 × 31.2, and finally, to 2.65 × 50.0 nM. (From top to bottom) plotted are the absolute change of PLCγ, rate of change of PLCγ, and rate of change of ERK. Note that the number of proliferations is decreasing gradually and finally disappears at a phase transition between the EGF concentrations of 2.65 × 31.1 and 2.65 × 31.2 nM. (For phenotype labeling see Fig. 4).