Figure 11

Habituation to increased firing. At one hour, the firing rate of the neuron is increased from 5 Hz to 15 Hz and eda immediately triples. Then eda gradually decreases to an intermediate value since the increased binding of eda to the autoreceptors inhibits TH and this causes a gradual decline in vesicular dopamine over a nine hour period. Thus the level of eda habituates to the increased firing rate.