Figure 3

Dynamic effects of substrate inhibition. Panel A shows the time courses of blood tyrosine concentration (assumed, see text) and intracellular tyrosine concentration (computed) over a two day period. Panel B shows the time courses of the velocity of the TH reaction over a two day period in response to meals both with and without substrate inhibition. The fluctuations are much smaller when substrate inhibition is present. Panel C shows the time courses of vesicular dopamine in response to meals over a two day period both with and without substrate inhibition. The fluctuations are much smaller when substrate inhibition is present.