Homeostatic mechanisms in dopamine synthesis and release: a mathematical model

Table 2 Kinetic Parameters (μ M, μ M/hr,/hr).

velocity	parameter	model value	literature value	references
V _AADC	aromatic amino acid decarboxylase
	K _m	130	130	[94]
	V _max	10,000		*
V _DAT	dopamine transporter
	K _m	.2	0.2-2	[75, 76]
	V _max	8000		*
V _DRR	dihydropteridine reductase
	K _{bh 2}	100	4-754	[95, 96]
	K _NADPH	75	29-770	[70–80, 97–99]
		200		*
	K _{bh 4}	10	1.1-17	[100, 98]
	K _NADP	75	29-770	[70–80, 97–99]
		80		*
V _MAT	vesicular monoamine transporter
	^K m	3	.2-10	[101–103]
	^V max	7082		*
	^k out	40		*
V _TH	tyrosine hydroxylase
	K _tyr	46	46	[60]
	K _{bh 4}	60	13,	[60]
	V _max	125		*
	K_i(cda)	110	110	[104]
	K_i(substrate inhibition)	160	46	[23, 60] ;160
	K_i(autoreceptors)			*
V _TYRin	neutral amino acid transporter
	K _m	64	64	[51]
	V _max	400		*
tyr ↔ tyrpool
	k ₁	6		*
	k _-1	0.6		*
catabolism and diffusion
		0.2		*
		10		*
		30		*
		3	3.3	[68]
		3.45	3.45	[69, 70]
		0.2		*
	k _rem	400		*

ISSN: 1742-4682