Figure 10
From: A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets
Calculated insulin concentrations shown as height data. Surfaces are color-coded for oxygen concentration (blue high, red low) for the same configuration and time-point shown in Figure 7 for free islets in normoxic (p O2 = 140 mmHg) (A) and hypoxic conditions (p O2 = 25 mmHg) (B) as well as for encapsulated islets in normoxic conditions (C). The insulin secreting ability of the large islet is more severely affected by hypoxia as clearly indicated by the changes in relative height between A and B (note different scales).