Figure 11
From: A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets
![Figure 11](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1742-4682-8-20/MediaObjects/12976_2011_Article_293_Fig11_HTML.jpg)
Calculated GSIR in perifused free vs. encapsulated islets. Insulin outflow calculated in response to stepwise glucose increments from 1 mM (G1) to 30 mM (G30) under normoxic (continuous line, pO2 = 140 mmHg) and slightly hypoxic (dashed line; pO2 = 45 mmHg) conditions for free (red) vs. encapsulated islets (orange). The response of normoxic free islets is the same as given in Figure 4.