From: A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets
Model | Var. | C Hf | n | R max | Comments |
---|---|---|---|---|---|
R oxy, oxygen consumption, base | c oxy | 1 μM | 1 | -0.034 mol/m3/s | Cut to 0 below critical value, c oxy <C cr,oxy. |
R oxy, oxygen consumption, φ o,g metabolic part | c gluc | 7 mM | 2.5 | N/A | Due to increasing metabolic demand; parallels second-phase insulin secretion rate. |
R gluc, glucose consumption | c gluc | 10 μM | 1 | -0.028 mol/m3/s | Contrary to oxygen, has no significant influence on model results. |
R ins,ph2, insulin secretion rate, second-phase | c gluc | 7 mM | 2.5 | 3 × 10-5 mol/m3/s | Total secretion rate is modulated by local oxygen availability (last row). |
R ins,ph1, insulin secretion rate, first-phase | ∂c gluc/∂t | 0.03 mM/s | 2 | 21 × 10-5 mol/m3/s | Modulated via eq. 8 to have maximum sensibility around c gluc = 5 mM and be limited at very large or low c gluc. |
Insulin secretion rate, φ o,g oxygen dependence | c oxy | 3 μM | 3 | N/A | To abruptly limit insulin secretion if c oxy becomes critically low. |