Figure 4

Plasma profiles. Profiles for three additional subjects are provided in Additional file 2. We used default parameter values to initialize HGI subjects and execute initial simulations. Grid size was set to 100 x 100, and probability parameters governing drug movement as specified in Table 1. Once initialized, the simulation was executed and stopped after a predefined number of time steps. Simulated plasma values were recorded each cycle and scaled in dose fraction to directly compare with the referent values. If the outcome failed to satisfy the prespecified SC, we adjusted parameter values and repeated simulation. We repeated the process for each referent profile until simulation measures achieved the SC. All simulations with Table 1 parameter values achieved the stringent SC. Red: referent plasma profile from the BE study; black: simulated profile from HGI subject.