From: The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model
Parameter | Value | Parameter Description |
---|---|---|
Compartment volumes (liters) | Â | Â |
vG | 1 | gut |
vP | 3 | plasma |
vL | 1.5 | liver |
vT | 30 | tissue |
vU | 1.5 | urine |
Transport parameters (μ M/hr) |  |  |
k gl | 4 | APAP from gut to liver |
k pt | 0.39 | APAP from plasma to tissue |
k tp | 0.78 | APAP from tissue to plasma |
k pl | 0.0225 | APAP from plasma to liver |
k lp | 0.2025 | APAP from liver to plasma |
k slp | 0.24 | sulfonate from liver to plasma |
k stp | 0.0913 | sulfonate from tissue to plasma |
k glp | 0.3024 | glucoronidate from liver to plasma |
k gtp | 0.5171 | glucoronidate from tissue to plasma |
k nqglp | 0.3 | NAPQI-GSH conjugate from liver to plasma |
k pu | 0.06 | APAP from plasma to urine |
k spu | 4 | sulfonate from plasma to urine |
k gpu | 3.8 | glucoronidate from pasma to urine |
k nqgpu | 0.4 | NAPQI-GSH conjugate from plasma to urine |
k u | 1.54 | urine elimination |
Hepatocyte parameters | Â | Â |
r | .0417 | logistic growth (h r−1) |
h max | (1. 6)1011 | maximum hepatocyte number |
η | (. 213)10−4. 2 | cell death rate due to NAPQI (h r−1μ M−1) |
δ z | .2083 | removal of dead hepatocytes (h r−1) |