Node in the | Nodes in the | Simplification criteria | Â |
---|---|---|---|
original BNM | simplified BNM | Â | Â |
ICL | ICL | Unchanged node | Â |
FANCM, FAcore | FAcore | ICL recognition proteins working | Â |
 |  | together in the upstream FA/BRCA |  |
 |  | pathway |  |
FANCD2I | FANCD2I | Unchanged node | Â |
MUS81 | NUC1 | Nuclease mediated | Â |
 |  | ICL incision |  |
XPF, FAN1 | NUC2 | Nuclease mediated | Â |
 |  | ICL incision |  |
ADD | ADD | Unchanged node | Â |
DSB | DSB | Unchanged node | Â |
ATR, CHK1, H2AX | ATR | These proteins act in the | Â |
 |  | Checkpoint pathway |  |
ATM, CHK2, H2AX | ATM | These proteins act in the | Â |
 |  | Checkpoint pathway |  |
p53 | p53 | Unchanged node | Â |
PCNATLS | TLS | This is only a change in name | Â |
FANCJMLH1, MRN, BRCA1, | FAHRR | These proteins act in the | Â |
FANCD1N, RAD51, HRR, | Â | Homologous Recombination | Â |
ssDNARPA | Â | Repair pathway | Â |
—— | HRR2 | New node representing the |  |
 |  | alternative Homologous |  |
 |  | Recombination Repair Pathway |  |
KU, DNAPK, NHEJ | NHEJ | These proteins act in the | Â |
 |  | Non-Homologous End-Joining |  |
 |  | DNA repair pathway |  |
USP1, CHKREC | CHKREC | Global negative regulators | Â |
 |  | of the FA/BRCA pathway |  |