Fig. 1

Modeling of voltage stability for ion channel combinations. Our approach for retrieving, calibrating, and simulating is diagrammed in (a). Currents (suppresing a factor of 2) for an arbitrary ion channel are schematized geometrically in (b); inward or outward currents are represented by wedge areas inside or outside the circle, respectively (c) Currents diagrammed using the method illustrated in b at three voltages above (top), below (bottom) and at (middle) a stable equilibrium for the Nav1.6 + leak model system, in mammals, with a 10:1 ratio of maximal conductances between Nav1.6 and leak channels. Arrows indicate the direction of voltage evolution. Note that in these diagrams, V and E have been shifted by +150 mV to be strictly positive. d Simulations of voltage evolution in the mammalian Nav1.6 + leak model after a 50 ms initial voltage-clamping period, with corresponding currents as indicated in c