Parameter\Case | Unit | Control | 1000 | 2000 | 3000 | 4000 |
---|
α | Gy−1
| Â |
0.30
|
0.20
|
0.16
|
0.145
|
Dose | Gy | Â | 10 | 20 | 30 | 40 |
Td(0) | days | 1.35 | 1.35 | 1.35 | 1.35 | 1.35 |
θ |  |
0.72
|
0.72
|
0.74
|
0.795
|
0.838
|
Tcl
| days | Â | 4 | 4 | 4 | 4 |
N | Â | 11 | 11 | 19 | 18 | 14 |
MSDb
| Â | 0.01883 | 0.01099 | 0.00816 | 0.00832 | 0.03039 |
AICc
|  | −59.76 | −66.00 | −137.31 | −128.23 | −75.86 |
Sd
|  | 1.00E + 00 | 9.83E-01 | 2.84E-01 | 5.38E-02 | 4.51E-03 |
-
aInitial volume = 0.0157 cm3. The radiation was turned on at the 11th day. The following model parameters were set constant: α/β = 10 Gy, active radiation-effect time τrad = 8 days, cell cycle time Tcc = 1 day, colony counting time Tm = 10 days
-
bMean square of difference between the experimental data and the model estimated volumes
-
cAIC defined by Eq.(33) with k = 5. The number of data points, N, is shown in the table
-
dS is the fraction of surviving cells after irradiation. It is not a parameter used in the simulation model. But, it is included in this table to show the degree of cell kill by radiation. See the text for details