Theory of synergistic effects: Hill-type response surfaces as ‘null-interaction’ models for mixtures

Table 4 Fit parameters for anesthetics and their mixtures

Drug	D ₅₀(mg/kg)	Slope	RMSE^a
Midazolam	0.144	4.83	0.054
Propofol	1.078	11.14	0.035
Alfentanil	0.093	5.69	0.069
Midazolam/propofol			0.387
Midazolam/alfentanil			0.477
Propofol/alfentanil			0.228
Ternary mixture			0.461

^aRMSE = root-mean-square error with respect to exptl. data. For pure compounds RMSE refers to fits, for mixtures it refers to predictions

ISSN: 1742-4682