From: Mathematical modeling of septic shock based on clinical data
Parameter | Value | Description | Source |
---|---|---|---|
C sa | 4ml/mmHg | Compliance of sa | [16] |
C sv | 111.11ml/mmHg | Compliance of sv | [16] |
C ra | 31.25ml/mmHg | Compliance of ra | [16] |
C pa | 6.56ml/mmHg | Compliance of pa | [16] |
C pv | 25.37ml/mmHg | Compliance of pv | [16] |
C la | 19.23ml/mmmHg | Compliance of la | [16] |
R s2 | 0.2247mmHg∙ s/ml | Hydraulic resistance of the systemic circulation upstream of arteriolar capillaries | [16] |
R s3 | 0.1124mmHg∙ s/ml | Hydraulic resistance of the systemic circulation downstream of arteriolar capillaries | [16] |
R sv | 0.011mmHg∙ s/ml | Hydraulic resistance of sv | [16] |
R pa | 0.1124mmHg∙ s/ml | Hydraulic resistance of pa | [16] |
R pv | 0.0056mmHg∙ s/ml | Hydraulic resistance of pv | [16] |
L a | 0.01ml/mmHg/s | Permeability coefficient of arterial capillaries | [16] |
L v | 0.062ml/mmHg/s | Permeability coefficient of venular capillaries | [16] |
V usa | 611.3ml | Unstressed volume of sa | [16] |
V ura | 25ml | Unstressed volume of ra | [16] |
V upa | 124ml | Unstressed volume of pa | [16] |
V upv | 120ml | Unstressed volume of pv | [16] |
V ula | 25ml | Unstressed volume of la | [16] |
k l | 20ml/mmHg | Slope of the stroke volume versus the atrial pressure relationship for the left heart | [16] |
k r | 34.028ml/mmHg | Slope of the stroke volume versus the atrial pressure relationship for the right heart | [16] |
p la0 | 2.8mmHg | x -axis intercept of the stroke volume versus atrial pressure relationship for the left heart | [16] |
p ra0 | 1.82mmHg | x -axis intercept of the stroke volume versus atrial pressure relationship for the right heart | [16] |
V n | 5300ml | Total blood volume in the basal condition | [16] |
V rc | 1300ml | Red blood cell volume | [16] |
p san | 100mmHg | Intravascular pressure in the sa in the basal condition | [16] |
p svn | 5mmHg | Intravascular pressure in the sv in the basal condition | [16] |
p ran | 4mmHg | Intravascular pressure in the ra in the basal condition | [16] |
p pan | 17mmHg | Intravascular pressure in the pa in the basal condition | [16] |
p pvn | 7mmHg | Intravascular pressure in the pv in the basal condition | [16] |
p lan | 6.5mmHg | Intravascular pressure in the la in the basal condition | [16] |
k Na | 25ml/s | Mass transfer coefficient of the cellular membrane for sodium | [16] |
β Na | 0.0704 | Mass transfer coefficient of the cellular membrane for sodium | [16] |
k K | 6.67 ∙ 10−2ml/s | Mass transfer coefficient of the cellular membrane for potassium | [16] |
β K | 28.2 | Mass transfer coefficient of the cellular membrane for potassium | [16] |
k U | 13ml/s | Mass transfer coefficient of the cellular membrane for urea | [16] |
β U | 1 | Mass transfer coefficient of the cellular membrane for urea | [16] |
k f | 4 ∙ 10−3L2/s/mmol | Water exchange coefficient of the cellular membrane | [16] |
M eq,ic | 150mmol | Amount of other osmotically efficient solutes in the intracellular compartment | [16] |
M eq,ex | 150mmol | Amount of other osmotically efficient solutes in the extracellular compartment | [16] |
E is | 24.5mmHg/L | Interstitial space elastance | [16] |
V isn | 11L | Basal volume of the interstitial fluid | [16] |
V icn | 25L | Basal volume of the intracellular fluid | [16] |
c p,pin | 7.4g/dl | Basal protein concentration in the plasma | [16] |
c p,isn | 1.37g/dl | Basal protein concentration in the interstitial fluid | [16] |
Mk,ic(0) | 3535mEq | Initial amount of potassium in the intracellular fluid | [16] |
Mk,ex(0) | 75mEq | Initial amount of potassium in the extracellular fluid | [16] |
MNa,ic(0) | 250mEq | Initial amount of sodium in the intracellular fluid | [16] |
MNa,ex(0) | 2130mEq | Initial amount of sodium in the intracellular fluid | [16] |
MU,ic(0) | 2130mEq | Initial amount of urea in the intracellular fluid | [16] |
MU,ex(0) | 375mmol | Initial amount of urea in the extracellular fluid | [16] |
Q F | 0.2083ml/s | Ultrafiltration rate of the replacement fluid | [16] |
Q inf | 0ml/s | Ultrafiltration rate of the replacement fluid | [16] |
c Na,d | 142mEq/L | Ultrafiltration rate of the replacement fluid | [16] |
c Kd | 62mEq/L | Ultrafiltration rate of the replacement fluid | [16] |
c Ud | 0 | Concentration of urea in the dialysate | [16] |
F p | 0.94 | Plasma fractions | [16] |
F R | 0.72 | Red blood cell water fractions | [16] |
γ U | 1 | Fraction of red blood cell water that participates in the transfer through the dialyzer | [16] |
R DU | 1 | Donnan ratio for urea in red cells | [16] |
γ Na | 0 | Fraction of red blood cell water that participates in the transfer through the dialyzer | [16] |
γ K | 0 | Fraction of red blood cell water that participates in the transfer through the dialyzer | [16] |
Q B | 3ml/s | Bulk blood flow through the dialyzer | [16] |
D Na | 2.67ml/s | Dialysance (or clearance) of sodium | [16] |
D K | 2.67ml/s | Dialysance (or clearance) of potassium | [16] |
D U | 2.67ml/s | Dialysance (or clearance) of urea | [16] |
σ Rn | 0.7303mmHg∙ s/ml | Basal value of the sigmodideal static characteristic for the mechanism of systemic resistance control | [16] |
ΔσR | 1.4mmHg∙ s/ml | Amplitude of the sigmodideal static characteristic for the mechanism of systemic resistance control | [16] |
τ R | 6s | Time constant of the mechanism of systemic resistance control | [16] |
G aR | 0.02/mmHg | Central gain of the arterial controls for the mechanism of systemic resistance control | [16] |
G cR | 0.7/mmHg | Central gain of the cardiopulmonary controls for the mechanism of systemic resistance control | [16] |
σ V n | 2900ml | Basal value of the sigmodideal static characteristic for the mechanism of venous unstressed volume control | [16] |
ΔσV | 500ml | Amplitude of the sigmodideal static characteristic for the mechanism of venous unstressed volume control | [16] |
τ V | 20s | Time constant of the mechanism of venous unstressed volume control | [16] |
G aV | 10.8/mmHg | Central gain of the arterial controls for the mechanism of venous unstressed volume control | [16] |
G cV | 417/mmHg | Central gain of the cardiopulmonary controls for the mechanism of venous unstressed volume control | [16] |
σ Tn | 0.833s | Basal value of the sigmodideal static characteristic for the mechanism of heart period control | [16] |
ΔσT | 0.75s | Amplitude of the sigmodideal static characteristic for the mechanism of heart period control | [16] |
τ T | 2s | Time constant of the mechanism of heart period control | [16] |
G aT | 0.015/mmHg | Central gain of the arterial controls for the mechanism of heart period control | [16] |
G cT | 0/mmHg | Central gain of the cardiopulmonary controls for the mechanism of heart period control | [16] |
p lat | 4.5mmHg | Threshold value of left atrial pressure for activation of the sympathoinhibitory mechanism | [16] |
G σ | 4.5mmHg | Gain constant of the sympathoinhibitory mechanism | [16] |
τ σ | 120s | Time constant of the sympathoinhibitory mechanism | [16] |
τ ϵ | 2700s(acetate dialysis only) | Time constant of the acetate effect upon peripheral vessels | [16] |