Drug | Type | Target | Class | IC50 | m | RCI95 | |||
---|---|---|---|---|---|---|---|---|---|
genotype 1b | genotype 2a | genotype 1b | genotype 2a | genotype 1b | genotype 2a | ||||
TPV (nM) | DAA | NS3 protease | PI | 323.79 | – | 1.72 | – | 5.54 | – |
DPV (nM) | DAA | NS3 protease | PI | 1.40 | – | 0.98 | – | 20.18 | – |
SMV (nM) | DAA | NS3 protease | PI | 0.45 | 153.95 | 1.10 | 3.10 | 14.54 | 2.59 |
ASV (nM) | DAA | NS3 protease | PI | 2.75 | 665.49 | 0.97 | 2.99 | 20.81 | 2.68 |
SOF (nM) | DAA | NS5B polymerase NI | NI | 120.48 | 843.74 | 1.66 | 3.02 | 5.89 | 2.65 |
VX (pM) | DAA | NS5B polymerase NNI | NNI | 107.58 | – | 1.81 | – | 5.08 | – |
DAS (nM) | DAA | NS5B polymerase NNI | NNI | 1.50 | 7203.98 | 0.99 | 0.73 | 19.57 | 56.39 |
NSV (nM) | DAA | NS5B polymerase NNI | NNI | 0.25 | – | 1.19 | – | 11.87 | – |
TGV (nM) | DAA | NS5B polymerase NNI | NNI | 8.92 | – | 1.01 | – | 18.45 | – |
DCV (nM) | DAA | NS5A | NS5AI | 0.10 | 0.13 | 1.11 | 3.68 | 14.19 | 2.23 |
LDV (nM) | DAA | NS5A | NS5AI | 0.67 | 30.80 | 0.96 | 6.11 | 21.48 | 1.62 |
IFNα (IU/ml) | HTA | – | IFN | 2.56 | – | 1.43 | – | 7.84 | – |
CsA (μg/m) | HTA | Cyclophilin | CI | 0.40 | – | 1.53 | – | 6.85 | – |
SCY (μM) | HTA | Cyclophilin | CI | 0.34 | – | 1.45 | – | 7.62 | – |