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Table 3 Performance of parameter estimation for the time‐concentration activity model

From: Stochastic time‐concentration activity models for cytotoxicity in 3D brain cell cultures

  B( δ Y i ) B( α X Y i ) B( δ Y s ) B( α X Y s )   
  ×10−2 Coverage probability
ModelA(t,c) LS ML LS ML LS ML LS ML LS ML
‘Different parameters’ .013 −.004 −.029 −.058 .009 .029 .005 .003 .86 [.84,.88] .78 [.75,.80]
‘Identical intercept’ .012 −.014 .023 −.018 −.005 .018 −.001 .002 .87 [.85,.89] .61 [.58,.64]
‘Identical slope’ −7.94 −7.91 23.9 23.5 .050 .094 −.057 −.055 .77 [.74,.79] .73 [.70,.75]
‘Identical rates’ 1.48 1.29 −1.64 −1.92 2.99 2.74 −2.75 −2.41 .81 [.79,.84] .58 [.55,.61]
  1. Bias B of least squares (LS) and maximum likelihood (ML) estimates and coverage probability with a 95% confidence interval of joint estimates for the time‐concentration activity model determined from 1000 simulations and fits of the scenarios each.