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Table 3 Performance of parameter estimation for the time‐concentration activity model

From: Stochastic time‐concentration activity models for cytotoxicity in 3D brain cell cultures

 

B( δ Y i )

B( α X Y i )

B( δ Y s )

B( α X Y s )

  
 

×10−2

Coverage probability

ModelA(t,c)

LS

ML

LS

ML

LS

ML

LS

ML

LS

ML

‘Different parameters’

.013

−.004

−.029

−.058

.009

.029

.005

.003

.86 [.84,.88]

.78 [.75,.80]

‘Identical intercept’

.012

−.014

.023

−.018

−.005

.018

−.001

.002

.87 [.85,.89]

.61 [.58,.64]

‘Identical slope’

−7.94

−7.91

23.9

23.5

.050

.094

−.057

−.055

.77 [.74,.79]

.73 [.70,.75]

‘Identical rates’

1.48

1.29

−1.64

−1.92

2.99

2.74

−2.75

−2.41

.81 [.79,.84]

.58 [.55,.61]

  1. Bias B of least squares (LS) and maximum likelihood (ML) estimates and coverage probability with a 95% confidence interval of joint estimates for the time‐concentration activity model determined from 1000 simulations and fits of the scenarios each.