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  1. Content type: Research

    The acidity of human body fluids, expressed by the pH, is physiologically regulated in a narrow range, which is required for the proper function of cellular metabolism. Acid-base disorders are common especiall...

    Authors: Filip Ježek and Jiří Kofránek

    Citation: Theoretical Biology and Medical Modelling 2018 15:14

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  2. Content type: Research

    Many vector-borne diseases co-circulate, as the viruses from the same family are also transmitted by the same vector species. For example, Zika and dengue viruses belong to the same Flavivirus family and are prim...

    Authors: Biao Tang, Xi Huo, Yanni Xiao, Shigui Ruan and Jianhong Wu

    Citation: Theoretical Biology and Medical Modelling 2018 15:13

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  3. Content type: Research

    Ketogenic therapy in the form of ketogenic diets or calorie restriction has been proposed as a metabolic treatment of high grade glioma (HGG) brain tumors based on mechanistic reasoning obtained mainly from an...

    Authors: Rainer J. Klement, Prasanta S. Bandyopadhyay, Colin E. Champ and Harald Walach

    Citation: Theoretical Biology and Medical Modelling 2018 15:12

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  4. Content type: Research

    Mathematical modeling has become a tool used to address many emerging diseases. One of the most basic and popular modeling frameworks is the compartmental model. Unfortunately, most of the available compartmen...

    Authors: Parinya Suparit, Anuwat Wiratsudakul and Charin Modchang

    Citation: Theoretical Biology and Medical Modelling 2018 15:11

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  5. Content type: Research

    Antiretroviral therapy (ART) has become the standard of care for patients with HIV infection in South Africa and has led to the reduction in AIDS related morbidity and mortality. In developing countries, the n...

    Authors: Claris Shoko and Delson Chikobvu

    Citation: Theoretical Biology and Medical Modelling 2018 15:10

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  6. Content type: Research

    Unlike the epidemic of yellow fever from 2016 to 17 in Brazil mostly restricted to the States of Minas Gerais and Espirito Santo, the epidemic from 2017 to 18 mainly involved São Paulo and Rio de Janeiro and r...

    Authors: Yohei Sakamoto, Takayuki Yamaguchi, Nao Yamamoto and Hiroshi Nishiura

    Citation: Theoretical Biology and Medical Modelling 2018 15:9

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  7. Content type: Research

    The process by which blood cells are formed is referred to as hematopoiesis. This process involves a complex sequence of phases that blood cells must complete. During hematopoiesis, a small fraction of cells unde...

    Authors: Christina L. Mouser, Eliana S. Antoniou and Evros K. Vassiliou

    Citation: Theoretical Biology and Medical Modelling 2018 15:8

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  8. Content type: Research

    Environmentally growing pathogens present an increasing threat for human health, wildlife and food production. Treating the hosts with antibiotics or parasitic bacteriophages fail to eliminate diseases that gr...

    Authors: Ilona Merikanto, Jouni T. Laakso and Veijo Kaitala

    Citation: Theoretical Biology and Medical Modelling 2018 15:7

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  9. Content type: Research

    It is believed that sexually active people, i.e. people having multiple or concurrent sexual partners, are at a high risk of sexually transmitted infections (STI), but they are likely to be more aware of the r...

    Authors: Nao Yamamoto, Keisuke Ejima and Hiroshi Nishiura

    Citation: Theoretical Biology and Medical Modelling 2018 15:6

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  10. Content type: Research

    The effects of current anthropogenic influences on eelgrass (Zostera marina) meadows are noticeable. Eelgrass ecological services grant important benefits for mankind. Preservation of eelgrass meadows include sev...

    Authors: Héctor Echavarría-Heras, Cecilia Leal-Ramírez, Enrique Villa-Diharce and Nohe Cazarez-Castro

    Citation: Theoretical Biology and Medical Modelling 2018 15:4

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  11. Content type: Research

    As HIV enters the human body, its main target is the CD4 cell which it turns into a factory that produces millions of other HIV particles. These HIV particles target new CD4 cells resulting in the progression ...

    Authors: Claris Shoko and Delson Chikobvu

    Citation: Theoretical Biology and Medical Modelling 2018 15:3

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  12. Content type: Research

    The small intestinal epithelium is a dynamic system with specialized cell types. The various cell populations of this tissue are continually renewed and replenished from stem cells that reside in the small int...

    Authors: Erik R. Barthel

    Citation: Theoretical Biology and Medical Modelling 2017 14:25

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  13. Content type: Research

    Increased computational resources have made individual based models popular for modelling epidemics. They have the advantage of incorporating heterogeneous features, including realistic population structures (...

    Authors: Abhishek Bakuli, Frank Klawonn, André Karch and Rafael Mikolajczyk

    Citation: Theoretical Biology and Medical Modelling 2017 14:26

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  14. Content type: Research

    National or local laws, norms or regulations (sometimes and in some countries) require medical providers to report notifiable diseases to public health authorities. Reporting, however, is almost always incompl...

    Authors: Marcos Amaku, Marcelo Nascimento Burattini, Eleazar Chaib, Francisco Antonio Bezerra Coutinho, David Greenhalgh, Luis Fernandez Lopez and Eduardo Massad

    Citation: Theoretical Biology and Medical Modelling 2017 14:23

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  15. Content type: Research

    Histamine (HA), a small molecule that is synthesized from the amino acid histidine, plays an important role in the immune system where it is associated with allergies, inflammation, and T-cell regulation. In t...

    Authors: Janet Best, H. F. Nijhout, Srimal Samaranayake, Parastoo Hashemi and Michael Reed

    Citation: Theoretical Biology and Medical Modelling 2017 14:24

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  16. Content type: Research

    Matching the frequency of the driving force to that of the system’s natural frequency of vibration results in greater amplitude response. Thus we hypothesize that applying ultrasound at the chondrocyte’s reson...

    Authors: April D. Miller, Anuradha Subramanian and Hendrik J. Viljoen

    Citation: Theoretical Biology and Medical Modelling 2017 14:21

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  17. Content type: Research

    Following the formation of a primary carcinoma, neoplastic cells metastasize by undergoing the epithelial mesenchymal transition (EMT), which is triggered by cues from inflammatory and stromal cells in the mic...

    Authors: Kelsey Gasior, Marlene Hauck, Alyson Wilson and Sudin Bhattacharya

    Citation: Theoretical Biology and Medical Modelling 2017 14:19

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  18. Content type: Review

    The genetic diversity of cancer and the dynamic interactions between heterogeneous tumor cells, the stroma and immune cells present daunting challenges to the development of effective cancer therapies. Althoug...

    Authors: Youcef Derbal

    Citation: Theoretical Biology and Medical Modelling 2017 14:18

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  19. Content type: Research

    Despite high vaccination coverage, many childhood infections pose a growing threat to human populations. Accurate disease forecasting would be of tremendous value to public health. Forecasting disease emergenc...

    Authors: Paige B. Miller, Eamon B. O’Dea, Pejman Rohani and John M. Drake

    Citation: Theoretical Biology and Medical Modelling 2017 14:17

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  20. Content type: Review

    The public benefit of test-and-treat has induced a need to justify goodness for the public, and mathematical modeling studies have played a key role in designing and evaluating the test-and-treat strategy for ...

    Authors: Kyeongah Nah, Hiroshi Nishiura, Naho Tsuchiya, Xiaodan Sun, Yusuke Asai and Akifumi Imamura

    Citation: Theoretical Biology and Medical Modelling 2017 14:16

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  21. Content type: Research

    A large epidemic of cholera, caused by Vibrio cholerae, serotype Ogawa, has been ongoing in Yemen, 2017. To improve the situation awareness, the present study aimed to forecast the cholera epidemic, explicitly ad...

    Authors: Hiroshi Nishiura, Shinya Tsuzuki, Baoyin Yuan, Takayuki Yamaguchi and Yusuke Asai

    Citation: Theoretical Biology and Medical Modelling 2017 14:14

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  22. Content type: Research

    Herpes Simplex Virus Type 2 (HSV-2) is one of the most common sexually transmitted diseases. Although there is still no licensed vaccine for HSV-2, a theoretical investigation of the potential effects of a vac...

    Authors: Jinliang Wang, Xiaoqing Yu, Heidi L. Tessmer, Toshikazu Kuniya and Ryosuke Omori

    Citation: Theoretical Biology and Medical Modelling 2017 14:13

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  23. Content type: Research

    With up to 240 million people chronically infected with hepatitis B worldwide, including an estimated 2 million in the United States, widespread screening is needed to link the infected to care and decrease th...

    Authors: Martin A. Sehr, Kartik D. Joshi, John M. Fontanesi, Robert J. Wong, Robert R. Bitmead and Robert G. Gish

    Citation: Theoretical Biology and Medical Modelling 2017 14:11

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  24. Content type: Research

    The host range of human immunodeficiency virus (HIV) is quite narrow. Therefore, analyzing HIV-1 pathogenesis in vivo has been limited owing to lack of appropriate animal model systems. To overcome this, chime...

    Authors: Shoya Iwanami, Yusuke Kakizoe, Satoru Morita, Tomoyuki Miura, Shinji Nakaoka and Shingo Iwami

    Citation: Theoretical Biology and Medical Modelling 2017 14:9

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  25. Content type: Research

    When administering vancomycin hydrochloride (VCM), the initial dose is adjusted to ensure that the steady-state trough value (Css-trough) remains within the effective concentration range. However, the Css-trou...

    Authors: Yasuyuki Kourogi, Kenji Ogata, Norito Takamura, Jin Tokunaga, Nao Setoguchi, Mitsuhiro Kai, Emi Tanaka and Susumu Chiyotanda

    Citation: Theoretical Biology and Medical Modelling 2017 14:8

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  26. Content type: Research

    Arteriovenous fistula (AVF) maturation failure remains a major cause of morbidity and mortality in hemodialysis patients. The two major etiologies of AVF maturation failure are early neointimal hyperplasia dev...

    Authors: Daniel Pike, Yan-Ting Shiu, Maheshika Somarathna, Lingling Guo, Tatyana Isayeva, John Totenhagen and Timmy Lee

    Citation: Theoretical Biology and Medical Modelling 2017 14:5

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  27. Content type: Research

    The transmission dynamics of Tuberculosis (TB) involve complex epidemiological and socio-economical interactions between individuals living in highly distinct regional conditions. The level of exogenous reinfe...

    Authors: Victor Moreno, Baltazar Espinoza, Kamal Barley, Marlio Paredes, Derdei Bichara, Anuj Mubayi and Carlos Castillo-Chavez

    Citation: Theoretical Biology and Medical Modelling 2017 14:3

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  28. Content type: Research

    Urine production in the kidney is generally thought to be an energy-intensive process requiring large amounts of metabolic activity to power active transport mechanisms. This study uses a thermodynamic analysi...

    Authors: Robert H. Louw, David M. Rubin, David Glasser, Robyn F. R. Letts and Diane Hildebrandt

    Citation: Theoretical Biology and Medical Modelling 2017 14:2

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  29. Content type: Research

    The progression of Human Immunodeficiency Virus (HIV) within host includes typical stages and the Antiretroviral Therapy (ART) is shown to be effective in slowing down this progression. There are great challen...

    Authors: Yanni Xiao, Xiaodan Sun, Sanyi Tang, Yicang Zhou, Zhihang Peng, Jianhong Wu and Ning Wang

    Citation: Theoretical Biology and Medical Modelling 2017 14:1

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  30. Content type: Research

    Florida State has reported autochthonous transmission of Zika virus since late July 2016. Here we assessed the transmissibility associated with the outbreak and generated a short-term forecast.

    Authors: Linh Dinh, Gerardo Chowell, Kenji Mizumoto and Hiroshi Nishiura

    Citation: Theoretical Biology and Medical Modelling 2016 13:20

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  31. Content type: Research

    Epidemic models are being extensively used to understand the main pathways of spread of infectious diseases, and thus to assess control methods. Schools are well known to represent hot spots for epidemic sprea...

    Authors: Valentina Clamer, Ilaria Dorigatti, Laura Fumanelli, Caterina Rizzo and Andrea Pugliese

    Citation: Theoretical Biology and Medical Modelling 2016 13:19

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  32. Content type: Research

    An artificial neural network approach was chosen to model the outcome of the complex signaling pathways in the gastro-intestinal tract and other peripheral organs that eventually produce the satiety feeling in...

    Authors: Shaji Krishnan, Henk F. J. Hendriks, Merete L. Hartvigsen and Albert A. de Graaf

    Citation: Theoretical Biology and Medical Modelling 2016 13:17

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  33. Content type: Research

    This study is mainly motivated by the need of understanding how the diffusion behavior of a biomolecule (or even of a larger object) is affected by other moving macromolecules, organelles, and so on, inside a ...

    Authors: Matteo Gori, Irene Donato, Elena Floriani, Ilaria Nardecchia and Marco Pettini

    Citation: Theoretical Biology and Medical Modelling 2016 13:13

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  34. Content type: Research

    Dengue is a common mosquito-borne viral disease epidemic especially in tropical and sub-tropical regions where water sanitation is not substantially controlled. However, dengue epidemics sometimes occur in non...

    Authors: Hiroki Masui, Itsuki Kakitani, Shumpei Ujiyama, Kazuyoshi Hashidate, Masataka Shiono and Kazue Kudo

    Citation: Theoretical Biology and Medical Modelling 2016 13:12

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