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Theoretical Biology and Medical Modelling

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  1. Content type: Research

    Increased computational resources have made individual based models popular for modelling epidemics. They have the advantage of incorporating heterogeneous features, including realistic population structures (...

    Authors: Abhishek Bakuli, Frank Klawonn, André Karch and Rafael Mikolajczyk

    Citation: Theoretical Biology and Medical Modelling 2017 14:26

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  2. Content type: Research

    National or local laws, norms or regulations (sometimes and in some countries) require medical providers to report notifiable diseases to public health authorities. Reporting, however, is almost always incompl...

    Authors: Marcos Amaku, Marcelo Nascimento Burattini, Eleazar Chaib, Francisco Antonio Bezerra Coutinho, David Greenhalgh, Luis Fernandez Lopez and Eduardo Massad

    Citation: Theoretical Biology and Medical Modelling 2017 14:23

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  3. Content type: Research

    Histamine (HA), a small molecule that is synthesized from the amino acid histidine, plays an important role in the immune system where it is associated with allergies, inflammation, and T-cell regulation. In t...

    Authors: Janet Best, H. F. Nijhout, Srimal Samaranayake, Parastoo Hashemi and Michael Reed

    Citation: Theoretical Biology and Medical Modelling 2017 14:24

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  4. Content type: Research

    Matching the frequency of the driving force to that of the system’s natural frequency of vibration results in greater amplitude response. Thus we hypothesize that applying ultrasound at the chondrocyte’s reson...

    Authors: April D. Miller, Anuradha Subramanian and Hendrik J. Viljoen

    Citation: Theoretical Biology and Medical Modelling 2017 14:21

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  5. Content type: Research

    Following the formation of a primary carcinoma, neoplastic cells metastasize by undergoing the epithelial mesenchymal transition (EMT), which is triggered by cues from inflammatory and stromal cells in the mic...

    Authors: Kelsey Gasior, Marlene Hauck, Alyson Wilson and Sudin Bhattacharya

    Citation: Theoretical Biology and Medical Modelling 2017 14:19

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  6. Content type: Review

    The genetic diversity of cancer and the dynamic interactions between heterogeneous tumor cells, the stroma and immune cells present daunting challenges to the development of effective cancer therapies. Althoug...

    Authors: Youcef Derbal

    Citation: Theoretical Biology and Medical Modelling 2017 14:18

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  7. Content type: Research

    Despite high vaccination coverage, many childhood infections pose a growing threat to human populations. Accurate disease forecasting would be of tremendous value to public health. Forecasting disease emergenc...

    Authors: Paige B. Miller, Eamon B. O’Dea, Pejman Rohani and John M. Drake

    Citation: Theoretical Biology and Medical Modelling 2017 14:17

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  8. Content type: Review

    The public benefit of test-and-treat has induced a need to justify goodness for the public, and mathematical modeling studies have played a key role in designing and evaluating the test-and-treat strategy for ...

    Authors: Kyeongah Nah, Hiroshi Nishiura, Naho Tsuchiya, Xiaodan Sun, Yusuke Asai and Akifumi Imamura

    Citation: Theoretical Biology and Medical Modelling 2017 14:16

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  9. Content type: Research

    A large epidemic of cholera, caused by Vibrio cholerae, serotype Ogawa, has been ongoing in Yemen, 2017. To improve the situation awareness, the present study aimed to forecast the cholera epidemic, explicitly ad...

    Authors: Hiroshi Nishiura, Shinya Tsuzuki, Baoyin Yuan, Takayuki Yamaguchi and Yusuke Asai

    Citation: Theoretical Biology and Medical Modelling 2017 14:14

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  10. Content type: Research

    Herpes Simplex Virus Type 2 (HSV-2) is one of the most common sexually transmitted diseases. Although there is still no licensed vaccine for HSV-2, a theoretical investigation of the potential effects of a vac...

    Authors: Jinliang Wang, Xiaoqing Yu, Heidi L. Tessmer, Toshikazu Kuniya and Ryosuke Omori

    Citation: Theoretical Biology and Medical Modelling 2017 14:13

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  11. Content type: Research

    With up to 240 million people chronically infected with hepatitis B worldwide, including an estimated 2 million in the United States, widespread screening is needed to link the infected to care and decrease th...

    Authors: Martin A. Sehr, Kartik D. Joshi, John M. Fontanesi, Robert J. Wong, Robert R. Bitmead and Robert G. Gish

    Citation: Theoretical Biology and Medical Modelling 2017 14:11

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  12. Content type: Research

    The host range of human immunodeficiency virus (HIV) is quite narrow. Therefore, analyzing HIV-1 pathogenesis in vivo has been limited owing to lack of appropriate animal model systems. To overcome this, chime...

    Authors: Shoya Iwanami, Yusuke Kakizoe, Satoru Morita, Tomoyuki Miura, Shinji Nakaoka and Shingo Iwami

    Citation: Theoretical Biology and Medical Modelling 2017 14:9

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  13. Content type: Research

    When administering vancomycin hydrochloride (VCM), the initial dose is adjusted to ensure that the steady-state trough value (Css-trough) remains within the effective concentration range. However, the Css-trou...

    Authors: Yasuyuki Kourogi, Kenji Ogata, Norito Takamura, Jin Tokunaga, Nao Setoguchi, Mitsuhiro Kai, Emi Tanaka and Susumu Chiyotanda

    Citation: Theoretical Biology and Medical Modelling 2017 14:8

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  14. Content type: Research

    Arteriovenous fistula (AVF) maturation failure remains a major cause of morbidity and mortality in hemodialysis patients. The two major etiologies of AVF maturation failure are early neointimal hyperplasia dev...

    Authors: Daniel Pike, Yan-Ting Shiu, Maheshika Somarathna, Lingling Guo, Tatyana Isayeva, John Totenhagen and Timmy Lee

    Citation: Theoretical Biology and Medical Modelling 2017 14:5

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  15. Content type: Research

    The transmission dynamics of Tuberculosis (TB) involve complex epidemiological and socio-economical interactions between individuals living in highly distinct regional conditions. The level of exogenous reinfe...

    Authors: Victor Moreno, Baltazar Espinoza, Kamal Barley, Marlio Paredes, Derdei Bichara, Anuj Mubayi and Carlos Castillo-Chavez

    Citation: Theoretical Biology and Medical Modelling 2017 14:3

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  16. Content type: Research

    Urine production in the kidney is generally thought to be an energy-intensive process requiring large amounts of metabolic activity to power active transport mechanisms. This study uses a thermodynamic analysi...

    Authors: Robert H. Louw, David M. Rubin, David Glasser, Robyn F. R. Letts and Diane Hildebrandt

    Citation: Theoretical Biology and Medical Modelling 2017 14:2

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  17. Content type: Research

    The progression of Human Immunodeficiency Virus (HIV) within host includes typical stages and the Antiretroviral Therapy (ART) is shown to be effective in slowing down this progression. There are great challen...

    Authors: Yanni Xiao, Xiaodan Sun, Sanyi Tang, Yicang Zhou, Zhihang Peng, Jianhong Wu and Ning Wang

    Citation: Theoretical Biology and Medical Modelling 2017 14:1

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