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Figure 1 | Theoretical Biology and Medical Modelling

Figure 1

From: Structural mimicry between SLA/LP and Rickettsia surface antigens as a driver of autoimmune hepatitis: insights from an in silico study

Figure 1

Sequence comparison between the autoepitope of SLA/LP and the corresponding region of the 120 KDa surface antigen from Rickettsia prowazekii. Sequence comparison between the region encompassing the autoepitope of the human SLA/LP antigen [UniProt:Q9HD40] and the portion of the 120 KDa surface antigen from Rickettsia prowazekii [UniProt:Q9ZD49]. Numbers attached to the accession codes indicate the sequence positions of the displayed segments within the respective entire sequences. Amino acid letters are colored according to conservation and physico-chemical properties. Annotations below alignment indicate the respective predicted secondary structure (red bars represent α-helices) and solvent accessibility. Sequence positions corresponding to B letters in the lines labeled 25% are predicted to expose to the solvent less than 25% of their total area. The black bar atop sequences denotes the peptide interacting with HLA-DRB1*03:01.

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682