Figure 2

Model’s survival states. The figure depicts the survival states – Bax, Bak representing nodes are inactive. The squares are depicting the terminal states of the model within the “configuration space”, where the configurations of states of nodes representing the antiapoptotic and BH3-only proteins are arranged along y- and x-axis, respectively. The black squares represent the “tumor” states, while the green squares represent the functionally “semioptimal” (light green) and “optimal” (dark green) survival states. While the first mentioned allow only the activation of Bak (transition T₄ in Figure 3), but not Bax, “optimal” states allow activation of both effectors.