Table 1 The parameters of the ABM
From: Multi-scale agent-based modeling on melanoma and its related angiogenesis analysis
Symbol | Variable | Initial value | Reference |
|---|---|---|---|
λ 0 | Normal death rate of melanoma cell | 0 | [28] |
w 1 | Regulatory factor of Equation 1 | 0.01 | Estimated |
w 2 | Regulatory factor of Equation 1 | 1 | Estimated |
λ 2 | Initial proliferation rate of melanoma cell | 32 h (16.9 h-47.3 h) | [28] |
λ g | Diffusion constant of glucose | 6.7 (5.2-7.2) × 10-7 cm2 /s | |
Pe g | Permeability for glucose | 3 × 10-5 (0.2-7)cm/s | |
U g | Glucose uptake rate of melanoma cell | 0.28Â mmol/h | [22] |
D g | Natural decay rate of glucose | 0.2 (0.1-0.4) | Estimated |
λ v | Diffusion constant of VEGF | 2.9 (1–9.4) × 10-7 cm2/ s | |
Se v | Secretion rate for VEGF | 0.6 (0.6-1) nM/h | [32] |
Pe v | Permeability for VEGF | 0.1 × 10-4 cm/s | |
D v | Natural decay rate of VEGF | 0.2 (0.1-0.4) | Estimated |
λ d | Diffusion constant of drug | 5.18 (1–10) × 10-7 cm2 /s | |
Pe d | Permeability for drug | 3 (0.2-7) × 10-5 cm/s | |
U d | Drug uptake rate | 0.2 (0.1-0.4) | Estimated |
w 3 | Regulator factor of Equation. 8 | 0.01 | Estimated |
λ 3 | Normal death rate of endothelia cell | 0 | [31] |
w 4 | Regulatory factor of Equation 13 | 0.01 | Estimated |
w 5 | Regulatory factor of Equation 13 | 1 | Estimated |
W 6 | Regulatory factor of Equation 14 | 0.01 | Estimated |