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Table 3 Relative CYP levels in ideal zonation cases

From: A physiologically-based flow network model for hepatic drug elimination II: variable lattice lobule models

Case Relative CYP Levels (Upstream/Middle/Downstream)
Average zonation 0.75/0.50/0.25 (U/M/D)
Extreme zonation 1.00/0.50/0.00 (U/M/D)
Average reverse zonation 0.25/0.50/0.75 (U/M/D)
Extreme reverse zonation 0.00/0.50/1.00 (U/M/D)