Modeling of the hypothalamic-pituitary-adrenal axis-mediated interaction between the serotonin regulation pathway and the stress response using a Boolean approximation: a novel study of depression

Table 1 Genes selected for knockout analysis

Node Name	Gene or Metabolite
TRP	Tryptophan
TPH 2	Tryptophan hydroxylase 2
5-HTP	5-hydroxytryptophan
AADC	Aromatic L-amino decarboxylase
5-HT*	Serotonin in the DRN
MAOA	Monoamine-oxidase A
SL18A2	Solute carrier 18A-2
5-HT	Synaptic serotonin
5-HT1A	Postsynaptic 5-HT receptor 1A^a
K-Channel	Presynaptic potassium channel ^a
K+	Postsynaptic potassium
5-HT1A*	Presynaptic 5-HT receptor 1A^a
K-Channel*	Presynaptic potassium channel ^a
K + *	Presynaptic potassium
5-HTT	Serotonin transporter
CREB	cAMP-response element binding
BDNF	Brain-derived neurotrophic factor
TRkB	Tyrosine kinase B
CRH	Corticotropin releasing hormone
VPA	Vasopressin
ACTH	Adrenocorticotropic hormone
cortisol	Cortisol
GR/MR_(PG)	Glucocorticoid/Mineralocorticoid receptor (pituitary gland)^b
GR/MR_(PVN)	Glucocorticoid/Mineralocorticoid receptor (paraventricular nucleus)^b
GR/MR_(DRN)	Glucocorticoid/Mineralocorticoid receptor (dorsal raphe nucleus)^b
GR/MR_(SSC)	Glucocorticoid/Mineralocorticoid receptor (sensitive serotonin cell)^b
NFkB	Nuclear factor

^a. Gene knocked out in a specific tissue, ^b. gene knocked out globally, * presynaptic node expressed in the dorsal raphe nucleus. (DRN) dorsal raphe nucleus, (PG) pituitary gland, (PVN) paraventricular nucleus, (SSC) sensitive serotonin cell.