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Table 1 Genes selected for knockout analysis

From: Modeling of the hypothalamic-pituitary-adrenal axis-mediated interaction between the serotonin regulation pathway and the stress response using a Boolean approximation: a novel study of depression

Node Name Gene or Metabolite
TRP Tryptophan
TPH 2 Tryptophan hydroxylase 2
5-HTP 5-hydroxytryptophan
AADC Aromatic L-amino decarboxylase
5-HT* Serotonin in the DRN
MAOA Monoamine-oxidase A
SL18A2 Solute carrier 18A-2
5-HT Synaptic serotonin
5-HT1A Postsynaptic 5-HT receptor 1Aa
K-Channel Presynaptic potassium channel a
K+ Postsynaptic potassium
5-HT1A* Presynaptic 5-HT receptor 1Aa
K-Channel* Presynaptic potassium channel a
K + * Presynaptic potassium
5-HTT Serotonin transporter
CREB cAMP-response element binding
BDNF Brain-derived neurotrophic factor
TRkB Tyrosine kinase B
CRH Corticotropin releasing hormone
VPA Vasopressin
ACTH Adrenocorticotropic hormone
cortisol Cortisol
GR/MR(PG) Glucocorticoid/Mineralocorticoid receptor (pituitary gland)b
GR/MR(PVN) Glucocorticoid/Mineralocorticoid receptor (paraventricular nucleus)b
GR/MR(DRN) Glucocorticoid/Mineralocorticoid receptor (dorsal raphe nucleus)b
GR/MR(SSC) Glucocorticoid/Mineralocorticoid receptor (sensitive serotonin cell)b
NFkB Nuclear factor
  1. a. Gene knocked out in a specific tissue, b. gene knocked out globally, * presynaptic node expressed in the dorsal raphe nucleus. (DRN) dorsal raphe nucleus, (PG) pituitary gland, (PVN) paraventricular nucleus, (SSC) sensitive serotonin cell.