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Table 2 Top-down and bottom-up mutations each produce adenomas

From: A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments

Position of mutation (cell rows from top)

Mutant cell type

Efficiency %

Top third (20)

Differentiated cell

 8.5

Lower third (59)

Proliferating cell

85

Bottom (65)

Quiescent stem cell

57

  1. Note: Efficiency is the percent of 200 crypts that achieved a size 40% larger than normal crypts in 500 time units.
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682