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Table 2 Top-down and bottom-up mutations each produce adenomas

From: A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments

Position of mutation (cell rows from top) Mutant cell type Efficiency %
Top third (20) Differentiated cell  8.5
Lower third (59) Proliferating cell 85
Bottom (65) Quiescent stem cell 57
  1. Note: Efficiency is the percent of 200 crypts that achieved a size 40% larger than normal crypts in 500 time units.