A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments

Table 2 Top-down and bottom-up mutations each produce adenomas

Position of mutation (cell rows from top)	Mutant cell type	Efficiency %
Top third (20)	Differentiated cell	8.5
Lower third (59)	Proliferating cell	85
Bottom (65)	Quiescent stem cell	57

Note: Efficiency is the percent of 200 crypts that achieved a size 40% larger than normal crypts in 500 time units.

ISSN: 1742-4682