Figure 6

Effect of inhibition of tumor cell Integrin αν/β3. Panel A demonstrates that inhibition of tumor cell Integrin αν/β3 reduces the fraction of circulating tumor cells bound to endothelial cells. aVB3 – Integrin αν/β3. *p <0.05. Panel B demonstrates that that this is due to a reduction in stable binding of circulating tumor cells to neutrophils (TC-PMN, Green) and tumor cells to endothelial cells (TC-EC, Blue), with neutrophil to endothelial cell binding (PMN-EC, Red) unaffected.