Figure 1

Structure of the model of erythropoiesis and granulopoiesis under chemotherapy, G-CSF and EPO application. Model compartments are presented in boxes (S = stem cells, BE = burst forming units - erythroid, CE = colony forming units - erythroid, PEB = proliferating erythrocytic blasts, MEB = maturing erythrocytic blasts, RET = reticulocytes, ERY = erythrocytes, EPO = erythropoietin, CG = granulopoietic progenitor cells (colony forming units of granulocytes and macrophages), PGB = proliferating granulopoietic precursor cells (myeloblasts, promyelocytes, myelocytes), MGB = maturing granulopoietic precursor cells (metamyelocytes, banded and segmented granulocytes)), GRA = granulocytes, LY = lymphocytes, CX = chemotherapy. Several regulatory feedback loops are displayed. The most important two are mediated by EPO and by G-CSF which are produced endogenously and could also be applied externally. Chemotherapy is modelled by a transient depletion of cells.