Bayesian approach for the estimation of cyclosporine area under the curve using limited sampling strategies in pediatric hematopoietic stem cell transplantation

Table 5 Final Pop-PK model parameter estimates

PK parameters		NONMEM fixed effect parameters		Inter-individual variability%
PK parameters		Estimate	RSE%	Estimate	RSE%
CL		θ1 = 15.66	5	17	11
		θ10 = -0.32	19
		θ11 = 0.0017	29
Vc		θ2 = 36.68	9	2	7
Vc		θ13 = -0.39	16	2	7
Q		θ3 = 14.71	9	55	15
Q		θ12 = 0.023	18	55	15
Vp		θ4 = 105	10	-	-
KA		θ5 = 0.8	15	72	10
ALAG		θ6 = 0.46	3	-	-
		θ8 = 0.005	5
		θ9 = -0.39 for suspension	19
		θ9 = -0.022 for capsule	18
		θ14 = -0.014	30
F		θ7 = 0.59	8	30	15
Residual error	Prop.	16
	Add.	19 ng/mL

CL = THETA (1) × ((WT/36.1) **0.75) × ((AG/11.82) **THETA(10)) × (1 + THETA(11) × (AP-99)) × EXP(ETA(1)).
Vc = THETA(2) × (WT/36.1) × ((AG/11.82) * * THETA(13)) × EXP(ETA(2)).
Q = THETA(3) × (1 + THETA(12) × (WT - 36.1)) × EXP(ETA(3)).
Vp = THETA(4).
KA = THETA(5) × EXP(ETA(4)).
ALAG = THETA(6) × EXP(THETA(8) × (TPT - 3.71)) × (1 + THETA(9)) × (1 + THETA(14) × (AG- 11.82)).
F = THETA(7) × EXP(ETA(5)).
CL: clearance, Vc: apparent volume of distribution of the central compartment, Vp: apparent volume of distribution of the peripheral compartment, Q: inter-compartmental transfer rate, KA absorption rate, ALAG: lag time in oral absorption, F: oral bioavailability, WT: weight, AG: age at profile date, TPT: time post transplantation, AP: alkaline phosphatase, FORM: dosage form, RSE%: relative standard errors.

ISSN: 1742-4682